2,3-Quinolinedicarboxylic acid
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2,3-Quinolinedicarboxylic acid
structure -
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CAS No:
643-38-9
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Formula:
C11H7NO4
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Chemical Name:
2,3-Quinolinedicarboxylic acid
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Synonyms:
2,3-Quinolinedicarboxylic acid;Acridinic acid;NSC 26342
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CAS No:
2,3-Quinolinedicarboxylic acid Basic Attributes
217.18
217.18
638FYR6T3N
26342
DTXSID9027281
2933499090
Characteristics
87.5
1.6
1.5±0.1 g/cm3
183 °C @ Solvent: Benzene, Ligroine
423.7°C at 760 mmHg
210.0±27.3 °C
1.720
2,3-Quinolinedicarboxylic acid Use and Manufacturing
The preparation method uses aniline and dimethyl butynedioate as raw materials to react, and the reaction product undergoes Vilsmeier reaction in the presence of phosphorus oxychloride and dimethylformamide to obtain 2, 3-quinoline-dicarboxylate methyl ester , And then hydrolyze in the presence of sulfuric acid to get the finished product. It is also possible to use aniline to react with diethyl 2, 3-dichlorosuccinate to produce diethyl 2-anilinofumarate, such as adding N, N-dimethylformamide in toluene solvent at room temperature Phosphorus oxychloride was added dropwise, and after the addition, the stirring was continued for 2 hours, and diethyl anilinobutenedioate was added dropwise, heated to reflux for 3 hours, the reaction was completed, the organic phase was washed with water, and toluene was separated by distillation to obtain quinoline-2, Diethyl 3-dicarboxylate.
Quinoline-2,3-dicarboxylic acid is an intermediate of the herbicide imidazoquinoline.
< 25,000 lb
2,3-Quinolinedicarboxylic acid: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Computed Properties
Molecular Weight:217.18
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:217.03750770
Monoisotopic Mass:217.03750770
Topological Polar Surface Area:87.5
Heavy Atom Count:16
Complexity:304
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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