Furo[3,4-b]pyridine-5,7-dione

white crystal powde

General procedure: Dicarboxylic acid 2 (1 mmol) and oxalyl chloride (1.2 mmol) were combined in dry toluene (5 mL) and a drop of freshly distilled DMF was added. The reaction vessel was purged with argon and the reaction was heated under stirring for 3 h. The stirring was stopped and the toluene solution was decanted off the oily residue and filtered. Evaporation of the volatiles provided the analytically pure target product which, if necessary, was transformed intro crystalline form by trituration with diethyl ether. In some cases (see ESI) additional crystallization or trituration with 1:2 v/v hexane-toluene mixture was used. .in room temperature, A mixture of 250 mL of acetic anhydrideAdded to1000ml of three bottles, 100.0 g (0.598 mol l.Oeq) of 2, 3-pyridinedicarboxylic acid was added, After finishing, Start heating to 110 ° C to reflux, After stirring for 2-3 hours, The reaction is complete, Cooled to room temperature, Add 500ml of carbon tetrachloride to precipitate a large amount of white solid, filter, The filter cake was rinsed with 100 mL of carbon tetrachloride, To give 64.0 g of the first product acid anhydride (yield 72.1percent), Do not need to go directly to the next step.A mixture of pyridine-2, 3-dicarboxylic acid (2 g, 12 mmol) and acetic anhydride was heated at 115° C. for 4 h.

Molecular Weight:149.10
XLogP3:0.6
Hydrogen Bond Acceptor Count:4
Exact Mass:149.011292958
Monoisotopic Mass:149.011292958
Topological Polar Surface Area:56.3
Heavy Atom Count:11
Complexity:214
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes