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Coptisine hydrochloride

Coptisine hydrochloride structure

CAS No:
6020-18-4
Formula:
C19H14NO4.Cl
Chemical Name:
Coptisine hydrochloride
Synonyms:
Bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium,6,7-dihydro-,chloride (1:1);Bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizinium,6,7-dihydro-,chloride;Berbinium,7,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)-,chloride;Coptisine chloride;Coptisine hydrochloride
Categories:
Biochemical Engineering > Plant Extracts

Description

Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

Coptisine hydrochloride Basic Attributes

Molecular Weight：

355.77

Exact Mass：

355.061127

EC Number：

1592732-453-0

NSC Number：

119754

Characteristics

PSA：

40.8

XLogP3：

-0.18820

Density：

1.51g/cm3

Melting Point：

218 °C

Boiling Point：

601.5°C at 760 mmHg

Flash Point：

190.4ºC

Refractive Index：

1.749

Storage Conditions：

Hygroscopic, Refrigerator, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P314, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

7,8,13,13a-tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium

Coptisine hydrochloride Use and Manufacturing

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.

Computed Properties

Molecular Weight:355.8
Hydrogen Bond Acceptor Count:5
Exact Mass:355.0611356
Monoisotopic Mass:355.0611356
Topological Polar Surface Area:40.8
Heavy Atom Count:25
Complexity:502
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Coptisine chloride

CAS No.: 6020-18-4

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CAS No.: 6020-18-4

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Guide of Coptisine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Coptisine hydrochloride

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