L-Leucinamide
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L-Leucinamide
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CAS No:
687-51-4
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Formula:
C6H14N2O
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Chemical Name:
L-Leucinamide
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Synonyms:
Pentanamide,2-amino-4-methyl-,(2S)-;Leucinamide,L-;Pentanamide,2-amino-4-methyl-,(S)-;(2S)-2-Amino-4-methylpentanamide;L-Leucinamide;L-Leucine amide;Leucine amide;H-Leu-NH2;(S)-2-Amino-4-methylpentanamide;(2S)-2-Amino-4-methylpentanamide
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CAS No:
Description
White crystalline powder
L-leucinamide is an amino acid amide that is L-leucine in which the carboxy OH group is replaced by NH2. It is an amino acid amide and a L-leucine derivative.
Characteristics
69.1
0.1
0.980±0.06 g/cm3(Predicted)
84-85 °C @ Solvent: Benzene, Ethanol
250.9°C at 760 mmHg
L-Leucinamide Use and Manufacturing
Into a 250 mE 24/40 joint single neck round bottomed flask equipped with a stir bar under nitrogen sparge was added a solution of 8.1 grams of (E)-Methyl Eeucinate (8.1 g, 0.056 mol) in 10 mE of MeOH. Aqueous NH4OH (28-30percent, 40 mE) was then added dropwise over approximately 20 minutes. The reaction was stirred 72 h under N2 atmosphere, and then concentrated under vacuum (.S-10 mm Hg) on a rotovap (l3uchi Rotovapor R-124, I3UCHI Eabortechnik AG, Switzerland). The residue was dissolved in water (250 mE) and extracted with CH2C12 (5x500 mE) using a separatory thnnel. The organic layers were combined into a 4 E Erlenmeyer flask, then dried (anhydrous Na2504), filtered to remove drying agent, and concentrated via rotovap under vacuum (5-10 mm Hg) to provide 5 grams of (S)-2-amino-4-methylpentanamide as a white solid.
Pentanamide, 2-amino-4-methyl-, (2S)-: ACTIVE
Computed Properties
Molecular Weight:130.19
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:130.110613074
Monoisotopic Mass:130.110613074
Topological Polar Surface Area:69.1
Heavy Atom Count:9
Complexity:101
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
