Methylene bis(thiocyanate)

130.19100

130.19

228-652-3

K1QS9QOS1J

1287

40464

2811

DTXSID8025599

Yellow to light orange-colored solid

2930909059

98.18000

1.37246

Methylenebis(thiocyanate) appears as yellow to light orange-colored mass or yellow powder. (NTP, 1992)

1.403 g/cm3

105-107 °C

285.2ºCat 760 mmHg

126.3ºC

1.6

Solubility in water: none

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition so

LD50 oral in rat: 55mg/kg

May be sensitive to prolonged exposure to air. Decomposes in water (not vigorously) and more rapidly in boiling water.

Isocyanates and Isothiocyanates

METHYLENEBIS(THIOCYANATE) reacts vigorously with strong bases and strong oxidizing agents such as hydrogen peroxide. Hydrolyzes slowly with water at boiling temperatures and reacts slowly and exothermically with aqueous acids (NTP, 1992).

II

8

UN 2811

3

R25; R26; R34; R43; R50

S26-S28-S36/37/39-S45-S61

XL1560000

T+; N

Separated from food and feedstuffs. Well closed.

Stable, but moisture sensitive. Reacts vigorously with strong bases, strong oxidizing agents. Reacts with water.

P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)|Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P320, P321, P330, P333+P313, P363, P391, P403+P233, P405, and P501|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|Aggregated GHS information provided by 148 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P309+P311, P310, P314, P320, P321, P330, P332+P313, P333+P313, P362, P363, P391, P403+P233, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)|In case of fire in the surroundings, use appropriate extinguishing media.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection. (NTP, 1992)

... skin irritant and /possible/ skin sensitizer. ...|... irritant to skin & eyes. ... /Aliphatic thiocyanates/

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from food and feedstuffs. Well closed.

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.

The substance is irritating to the eyes and skin.

Repeated or prolonged contact may cause skin sensitization.

PREVENT DISPERSION OF DUST! STRICT HYGIENE!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or eye protection in combination with breathing protection.

Methylene thiocyanate's production and use as a termiticide, wood preservative, slimicide and fungicide(1,2) will result in its release to the environment(SRC).

TERRESTRIAL FATE: Methylene thiocyanate is expected to hydrolyze in moist soils(1,SRC). Volatilization from soil surfaces and adsorption to soil are not expected to be important environmental fate processes because of hydrolysis(SRC).|AQUATIC FATE: Methylene thiocyanate is expected to hydrolyze in water within a few hours at neutral pH(1). Volatilization from water surfaces, adsorption to suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important in aquatic systems because of hydrolysis(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methylene thiocyanate, which has an estimated vapor pressure of 1.97X10-3 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methylene thiocyanate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 7 hours(3,SRC).

ONE OF THE BIOCIDE ACTIVE INGREDIENTS IN COOLING SYSTEMS METHYLENE BIS(THIOCYANATE) ACTS QUICKLY TO KILL MICROORGANISMS & THEN DISSIPATES IN A FEW HOURS AT NEUTRAL PH.|The rate constant for the vapor-phase reaction of methylene thiocyanate with photochemically-produced hydroxyl radicals has been estimated as 5.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 7 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2,SRC). Methylene thiocyanate is expected to hydrolyze in water within a few hours at neutral pH(3).

Bioconcentration is not expected to be an important environmental fate process for methylene thiocyanate because this compound is expected to hydrolyze in aquatic environments(1).

Adsorption of methylene thiocyanate is not expected to be important because this compound hydrolyzes rapidly(1).

Volatilization from water surfaces is not expected to be an important environmental fate process for methylene thiocyanate because this compound is expected to hydrolyze in aquatic environments(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 23,921 workers (918 of these are female) are potentially exposed to methylene thiocyanate in the US(1). Occupational exposure may occur through inhalation and dermal contact with this compound at workplaces where methylene thiocyanate is produced or used(SRC). The general population may be exposed to methylene thiocyanate through inhalation and dermal contact with this compound where it is used as a termiticide, wood preservative, slimicide and fungicide(SRC).

... Chemical disposition studies of (14)C labeled methylene bis(thiocyanate) were conducted in male F344/N rats. In these studies more than 90% of the admin radioactivity was eliminated in 48 hr. ... As the dose was incr from 0.2 to 1 to 10 mg/kg, greater percentages of the admin radioactivity remained in the tissues. Blood cyanide concn were incr shortly after the admin of 10 mg/kg (14)C methylene bis(thiocyanate) but were similar to control values 2 hr after dosing.

SYMPTOMS: Symptoms of exposure to this compound include severe eye damage, skin and respiratory tract irritation, corrosion, breathing difficulty, pulmonary edema and allergic skin reactions. It may also cause lacrimation. ACUTE/CHRONIC HAZARDS: This compound is a lacrimator. It can cause severe eye damage, skin irritation and corrosive. When heated to decomposition it emits toxic fumes of nitrogen oxides and sulfur oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

a total of 34 workers in a paper mill exposed to small amounts of slimicide used in paper and board manufacturing were tested for sensitization potential to methylene-bis-thiocyanate, a component of cytox-3522. The chemicals used in the factory were fennosan-M9 and germirex-849 containing 9 and 10% of methylene-bis-thiocyanate. There were no dermatological symptoms in any of the workers tested. Workers with positive reactions to high concn of cytox-3522 were tested with 0.1 and 0.03% cytox-3522. The patch tests were applied for 24 hr and read on the third and fifth days. No subject had definite positive reactions to cytox-3522. Three had irritant reactions. /The results suggest/ ... that chemicals containing methylene-bis-thiocyanate are not strong human contact sensitizers. ...

methylene bis(thiocyanate)

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Redness. Pain.

Redness. Pain.

Thiocyanic acid, C,C'-methylene ester: ACTIVE|CONTROLS FUNGAL DISEASES AND NEMATODES IN PLANTS SUCH AS RICE.|A REVIEW OF THE USE OF ORG THIOCYANATES, SUCH AS METHYLENE BISTHIOCYANATE, AS INDUST ANTIMICROBIAL AGENTS, SUCH AS IN SLIME CONTROL IN THE PAPER INDUSTRY.|METHYLENE BISTHIOCYANATE & ITS DERIV ARE EFFECTIVE DORMANCY REMOVING AGENTS FOR BARNYARD GRASS, LETTUCE, & MULBERRY SEEDS.

Agrochemicals -> Fungicides