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Home > Encyclopedia > 4-Acryloylmorpholine

4-Acryloylmorpholine

4-Acryloylmorpholine structure

4-Acryloylmorpholine 

structure
  • CAS No:

    5117-12-4

  • Formula:

    C7H11NO2

  • Chemical Name:

    4-Acryloylmorpholine

  • Synonyms:

    4-ACRYLOYLMORPHOLINE;N-Acrolylmorpholine;N-Acrylylmorpholine;ACRYOYL MORPHOLINE;4-Acryloylmorpholine (stabilized with MEHQ);Morpholine, 4-(1-oxo-2-propenyl)-;Acryloylmorpholin;4-ACRYLOYLMORPHOLINE, 98+%, STAB. WITH 4-METHOXYPHENOL

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

4-Acryloylmorpholine is an organic compound with the chemical formula C₇H₁₁NO₂. This compound has a unique molecular structure that makes it suitable for participating in a variety of chemical reactions and has a wide range of applications in several fields. Specifically, the molecular structure of 4-Acryloylmorpholine contains an acrylyl group which is attached to a morpholine ring. This structural feature gives it great potential as a reactive monomer. Due to its unique chemical properties, 4-Acryloylmorpholine has shown a wide range of applications in many fields such as coatings, adhesives, polymer synthesis and medicine. For example, in the coating industry, it can be used as a modifier to improve the performance of coatings; In the field of adhesives, it can improve the bonding strength and durability of adhesives; In polymer synthesis, it can participate in polymerization reaction as a monomer to form polymer materials with specific functions. In the field of medicine, it can be used as an intermediate in drug synthesis for the preparation of drug molecules with specific curative effects. In addition, due to the high reactivity of 4-Acryloylmorpholine, it can be used as an important intermediate in the synthesis of other compounds. This reactivity makes it important in organic synthetic chemistry, enabling chemists to design and synthesize complex molecules with specific structures and functions. In the actual application process, the use of 4-Acryloylmorpholine must strictly comply with the relevant safety specifications to ensure the safety of operators and the protection of the environment. To better understand and master its safe use, operators should refer to the relevant Material Safety Data Sheet (MSDS), which details important information about the chemical and physical properties, potential hazards, safety precautions, and emergency treatment of the compound. 4-Acryloylmorpholine is a chemical compound with important chemical properties and wide application potential, suitable for a variety of industrial production and scientific research fields. Through rational use of its unique chemical structure and reactivity, more products and technologies with practical application value can be developed.


4-Acryloylmorpholine (4-AM) is a water-soluble monomer, an acrylamide derivative containing a heterocyclic tetrahydrooxazine substituent. Homo- and copolymers of 4-АМ have several valuable properties. They are soluble both in water and in many organic solvents such as alcohols, chloroform, tetrahydrofuran, and dioxane, are non-toxic, and are used for solid-phase synthesis of peptides in chromatography, as materials for composite semipermeable membranes, in catalysis, and for biomedical purposes. Various functional groups are introduced into poly-4-AM to expand its application fields. Random copolymers of 4-АМ with carboxylic acids (acrylic, 4-pentenoic, undecenoic, 2-acrylamido-2-methyl-1-propanesulfonic), behaving as anionic polyelectrolytes, and copolymers with N-hydroxysuccinimide ester of acrylic acid, acting as polymeric carriers, have been synthesized[2-3].


4-Acryloylmorpholine has a melting point of 35 °C and is clear liquid at room temperature. At 25 °C, it has a density of 1.122 g/mL. It needs to be stored at 2-8°C.

4-Acryloylmorpholine Basic Attributes

141.17

141.17

119302

418-140-1

K0Y58P61JA

162221

TSCA listed

DTXSID0044947

Colorless to yellow

29349990

Characteristics

29.54000

-0.1

Liquid

1.122 g/mL at 25 °C(lit.)

−35 °C(lit.)

158°C 50mm

133.3±24.3 °C

n20/D1.512(lit.)

1000g/L at 20℃

1.03-1.64Pa at 25-29.9℃

Non flammable

-1.08±0.20(Predicted)

2-8°C

Safety Information

NONH for all modes of transport

2

Xn

23-26-36/37/39

Xn:Harmful;

P280-P305 + P351 + P338

22-41-43-48/22

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P280, P301+P312, P302+P352, P305+P351+P338, P310, P314, P321, P330, P333+P313, P363, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 62 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P260, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P311, P314, P321, P330, P333+P313, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 61 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

4-acryloylmorpholine

4-Acryloylmorpholine Use and Manufacturing

Uses

4-Acryloylmorpholine is used in adhesives, UV curable resins, industrial coatings, UV printing ink, oil recovery polymer, medicinal and commodity chemicals.

Adhesive manufacturing|2-Propen-1-one, 1-(4-morpholinyl)-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:141.17
XLogP3:-0.1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:141.078978594
Monoisotopic Mass:141.078978594
Topological Polar Surface Area:29.5
Heavy Atom Count:10
Complexity:139
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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