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Home > Encyclopedia > Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-)

Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-)

Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-) structure

Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-) 

structure
  • CAS No:

    1481-70-5

  • Formula:

    C66H87N13O13

  • Chemical Name:

    Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-)

  • Synonyms:

    Brevicidin;Rapicidin;Tyrocidine;Tyrocidines;Tyrocidine A;TrcA;UNII-V134656H89;EINECS 232-375-3;8011-61-8

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

Tyrocidine A is a homodetic cyclic decapeptide consisting of D-Phe, L-Pro, L-Phe, D-Phe, L-Asn, L-Gln, L-Tyr, L-Val, L-Orn, and L-Leu residues coupled in sequence and cyclised head-to-tail. It has a role as an antibacterial agent and a bacterial metabolite. It is a homodetic cyclic peptide, a peptide antibiotic and a macrocycle.|An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.

Cyclo(D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu-) Basic Attributes

1270.5

1269.655

232-375-3

V134656H89

DTXSID40163885|DTXSID70230079

Characteristics

415

2.8

Drug Information

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)

Brevicidin

Computed Properties

Molecular Weight:1270.5
XLogP3:2.8
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:19
Exact Mass:1269.65462988
Monoisotopic Mass:1269.65462988
Topological Polar Surface Area:415
Heavy Atom Count:92
Complexity:2510
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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