Sineptina
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Sineptina
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CAS No:
1392-21-8
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Formula:
C35H59NO13
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Chemical Name:
Sineptina
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Synonyms:
LEUCOMYCIN HYDRATE;FORMACIDINE;ayermicina;2-[6-[[5-[(4,5-dihydroxy-4,6-dimethyl-2-oxanyl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde;Leucomycin complex;Kitasamycin Solution, 1000ppm;Leucomycin hydrate, >=1300 units/mg;c637
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CAS No:
Description
Kitasamycin, formerly called leucomycin, was found in the culture broth of Streptoverticillium kitasatoensis by Hata et al. of the Kitasato Institute, Japan, in 1953. This was the first macrolide antibiotic with a 16-membered lactone constituent. Kitasamycin is a complex of eight leucomycin A components and is used in its base and ester forms to treat gram-positive bacterial and gram-negative coccal infections, as well as infections of Mycoplasma, Spirochaeta, and Treponema by injection or by oral topical administration.
White or yellow crystalline powder, odorless, bitter taste. Easily soluble in methanol, ethanol, acetone, ether and chloroform, insoluble in water, oral LD50 in mice (3.8±0.3)g/kg, oral LD50 in rats >8g/kg.
ChEBI: Leucomycin V is a macrolide antibiotic produced by Streptomyces kitasatoensis, showing activity against a wide spectrum of pathogens. It has a role as a bacterial metabolite. It is a leucomycin and a macrolide antibiotic.
Characteristics
194
128-145 °C
ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
2-8°C
mouse,LD50,intraperitoneal,1758mg/kg (1758mg/kg),Drugs in Japan Vol. -, Pg. 354, 1995.
Sealed in dry,2-8°C
Sineptina Use and Manufacturing
It is produced by fermentation of Strepeomyces kitasatoensis hata.
Leucomycin complex (kitasamycin) is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most abundant analogues. Leucomycin complex is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma.
Leucomycins (>85%) (cas# 1392-21-8) is a compound useful in organic synthesis.
Veterinary Drug -> ANTIMICROBIAL_AGENT; -> JECFA Functional Classes
Veterinary Drug -> ANTIMICROBIAL_AGENT;
Computed Properties
Molecular Weight:701.8
XLogP3:0.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:8
Exact Mass:701.39864094
Monoisotopic Mass:701.39864094
Topological Polar Surface Area:194
Heavy Atom Count:49
Complexity:1110
Defined Atom Stereocenter Count:16
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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Chongqing Xinda New Pharmaceutical Co., Ltd.
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China
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Shanghai Yurui BIOTECHNOLOGY (Anyang) Pharmaceutical Co., Ltd.
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China
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Yunnan Yong'an Pharmaceutical Co., Ltd.
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China
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