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Pyrazolo[1,5-a]pyridine

Pyrazolo[1,5-a]pyridine structure

CAS No:
274-56-6
Formula:
C7H6N2
Chemical Name:
Pyrazolo[1,5-a]pyridine
Synonyms:
Pyrazolo(1,5-a)pyridine;pyrazolo(3,4-b)pyridine;pyrazolo(3,4-c)pyridine;Pyrazolo[1,5-a]pyridine;Pyrazolo(2,3-a)pyridine;MFCD08752622;Pyrazolo[2,3-a]pyridine;pyrazolo[1,5-a]-pyridine;3-Azaindolizine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Pyrazolo[1,5-a]pyridine Basic Attributes

Molecular Weight：

118.139

Exact Mass：

118.053101

DSSTox ID：

DTXSID10181819

HScode：

2933990090

Characteristics

PSA：

17.3

XLogP3：

1.1

Density：

1.1±0.1 g/cm3

Boiling Point：

210.6°C at 760 mmHg

Refractive Index：

1.628

Safety Information

GHS Classification：

|Warning|H303 (100%): May be harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

Pyrazolo(1,5-a)pyridine

Pyrazolo[1,5-a]pyridine Use and Manufacturing

Sulfuric acid (50percent v/v in water) (200 mL, 410.1 mmol) was added to ethyl pyrazolo[1, 5-a]pyridine-3-carboxylate (78 g, 410.1 mmol) and the reaction was heated to reflux for 2 h 15 min. The reaction mixture was allowed to cool to room temperature and NaOH 50percent w/w solution (350 mL) was added dropwise over 60 min while maintaining the temperature below 35 °C using an ice bath. This was then poured into water (1 L), further NaOH (50percent w/w solution) (.similar.75 mL) was added until the mixture was basic and the resultant suspension was stirred until everything dissolved. This was extracted with MTBE (3.x.250 mL), the combined organic extracts were washed with water (500 mL) and saturated brine (500 mL). The organic layer was dried (NaBis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (Pd(Amphos)Cl

Computed Properties

Molecular Weight:118.14
XLogP3:1.1
Hydrogen Bond Acceptor Count:1
Exact Mass:118.053098200
Monoisotopic Mass:118.053098200
Topological Polar Surface Area:17.3
Heavy Atom Count:9
Complexity:103
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Pyrazolo{1,5-A)Pyridine

CAS No.: 274-56-6

Content: 99.00%

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