1-Propoxy-2-propanol

118.17

118.17

216-372-4

DTXSID5029217

29094990

29.5

0.49 (est)

Liquid; WetSolid

0.8886 g/cm³ @ Temp: 20 °C

-80 °C

148-149 °C @ Press: 730 Torr

119 °F

n 20/D 1.411(lit.)

Miscible with water

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

2.2125 mm Hg at 25 deg C

Henry's Law constant: 3.44X10-7 atm-cu m/mole at 25 °C (est)

III

3.2

UN 3271 3/PG 3

2

10-36/37/38

16-26-36

UB9351000

Xi

Stable under recommended storage conditions.

P210-P305 + P351 + P338-P370 + P378

H226-H319

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Incompatible materials: Strong oxidizing agents.

|Warning|H226 (99.27%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 2897 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226: Flammable liquid and vapor [Warning Flammable liquids]

Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Impervious clothing. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A skin and eye irritant.

1-Propoxy-2-propanol was tentatively and qualitatively detected in 1 (Dallas, TX, Nov 1974) of 16 samples of concentrate derived from large volume (>400 gallons) samples collected from 6 cities(1). 1-Propoxy-2-propanol was detected in volatiles given off of adhesive removers(2).

1-Propoxy-2-propanol is listed as an ingredient found in >40 cleaning products including auto, commercial, industrial, and home products(1).

IDENTIFICATION AND USE: 1-PROPOXY-2-PROPANOL is used in coatings, cleaners, inks. HUMAN EXPOSURE AND TOXICITY: No data. ANIMAL STUDIES: Instillation of 0.1, 0.01, or 0.005 mL into the eyes of rabbits caused severe conjunctivitis and diffusely mild corneal injury, requiring 3-14 days for complete resolution. Inhalation of substantially saturated vapor evolved at room temperature under may result in severe loss of coordination and anesthesia in rats. The test material has low acute oral toxicity. Following acute covered dermal application in rabbits, clinical signs included erythema, edema, ecchymosis, desquamation, anesthesia and eye irritation. Gross pathology revealed congested lungs, mottled livers and pale kidneys. In rats there were no treatment-related visceral or skeletal malformations, anomalies or variations with the exceptions of reduced ossification of hindlimb phalanges in litters of the 1500 ppm group observed in the presence of maternal toxicity. In rabbits maternal toxicity observed at 1500 ppm was evidenced by significant mortality (27.3%), reduction in weight gain and food and water consumption. Gestational parameters exhibited no significant changes, including the number of corpora lutea, total nonviable and viable implantations/litter, sex ratio, pre or postimplantation loss, and fetal body weights. No treatment-related visceral or skeletal malformations, anomalies or variations were observed. The chemical was negative in the genotoxicity testing using Salmonella typhimurium tester strains TA98, TA100, TA1535, and TA1537 and Escherichia coli tester strain WP2ucrA. The concentrations of the test material assay ranged from 100 to 5000 ug/plate. It was also was considered to be negative in the in vitro chromosomal aberration assay utilizing rat lymphocytes.

LD50 Rat oral 2.8 to 3.0 g/kg|LD50 Rabbit dermal 3.17 mL/kg|LD50 Rat oral 2,504 mg/kg|LD50 Rabbit dermal 3,550 mg/kg|For more Non-Human Toxicity Values (Complete) data for 1-PROPOXY-2-PROPANOL (8 total), please visit the HSDB record page.

1-Propoxy-2-propanol's production and use in coatings, cleaners and inks(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a structure estimation method(2), indicates that 1-propoxy-2-propanol is expected to have very high mobility in soil(SRC). Volatilization of 1-propoxy-2-propanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.4X10-7 atm-cu m/mole(SRC), based upon its vapor pressure, 2.21 mm Hg(3), and assigned value for water solubility of 1X10+6 mg/L (miscible)(3). 1-Propoxy-2-propanol is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). A biodegradation half-life of 10.5 days using OECD 301A guidelines(3) and a 64% of theoretical BOD reached after 20 days in an APHA method test(3) suggest that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2(SRC), determined from a structure estimation method(2), indicates that 1-propoxy-2-propanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.4X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 2.21 mm Hg(4), and assigned value for water solubility of 1X10+6 mg/L (miscible)(4). 1-Propoxy-2-propanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.49(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A biodegradation half-life of 10.5 days using OECD 301A guidelines(4) and a 64% of theoretical BOD reached after 20 days in an APHA method test(4) suggest that biodegradation is an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-propoxy-2-propanol, which has a vapor pressure of 2.21 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-propoxy-2-propanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Propoxy-2-propanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-propoxy-2-propanol with photochemically-produced hydroxyl radicals has been estimated as 2.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 15 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Propoxy-2-propanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 1-Propoxy-2-propanol does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for 1-propoxy-2-propanol(SRC), using an estimated log Kow of 0.49(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-propoxy-2-propanol can be estimated to be 2(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-propoxy-2-propanol is expected to have very high mobility in soil.

The Henry's Law constant for 1-propoxy-2-propanol is estimated as 3.4X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 2.21 mm Hg(1), and assigned value for water solubility of 1X10+6 mg/L (miscible)(1). This Henry's Law constant indicates that 1-propoxy-2-propanol is expected to be essentially nonvolatile from water and moist soil surfaces(2). The potential for volatilization of 1-propoxy-2-propanol from dry soil surfaces may exist based upon its vapor pressure(1).

According to the 2012 TSCA Inventory Update Reporting data, six reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of 1-propoxy-2-propanol in the United States may be as low as <10 workers up to the range of 100-499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,055 workers (434 of these are female) were potentially exposed to 1-propoxy-2-propanol in the US(1). Occupational exposure to 1-propoxy-2-propanol may occur through inhalation and dermal contact with this compound at workplaces where 1-propoxy-2-propanol is produced or used. Monitoring data indicate that the general population may be exposed to 1-propoxy-2-propanol via dermal contact and inhalation of vapors from consumer products containing 1-propoxy-2-propanol(SRC).

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/|Emergency and supportive measures. 1. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. 2. Treat coma, convulsions, cardiac arrhythmias, and metabolic acidosis if they occur. Observe the patient for several hours to monitor for development of metabolic acidosis, especially if the patient is symptomatic or there is known co-ingestion of ethanol. 3. Treat hypocalcemia with IV calcium gluconate or calcium chloride. /Ethylene glycol and other glycols/

1-propoxy-2-propanol

All other basic inorganic chemical manufacturing|2-Propanol, 1-propoxy-: ACTIVE

EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Solvent