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1-Phenylsemicarbazide

1-Phenylsemicarbazide structure

CAS No:
103-03-7
Formula:
C7H9N3O
Chemical Name:
1-Phenylsemicarbazide
Synonyms:
Hydrazinecarboxamide,2-phenyl-;Semicarbazide,1-phenyl-;2-Phenylhydrazinecarboxamide;Cryogenine;Cryogenine (pharmaceutical);Phenylsemicarbazide;1-Phenylsemicarbazide;1-Carbamyl-2-phenylhydrazine;Phenicarbazide;Carbaphen;Febrimin;Phenicarbazid;Phenygenine;1-Carbamoyl-2-phenylhydrazine;Kryogenin;NSC 2763;(Phenylamino)urea
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

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Description

Phenicarbazide is a member of phenylhydrazines.

1-Phenylsemicarbazide Basic Attributes

Molecular Weight：

151.17

Exact Mass：

151.17

EC Number：

203-072-3

UNII：

1LR2578324

NSC Number：

2763

DSSTox ID：

DTXSID9020245

HScode：

29280090

Characteristics

PSA：

67.2

XLogP3：

1.84600

Density：

1.2100 (rough estimate)

Melting Point：

172 °C

Boiling Point：

273.17°C (rough estimate)

Refractive Index：

1.5860 (estimate)

Water Solubility：

acetone: very soluble(lit.)

Toxicity：

Peritoneal-mouse LD50: 198 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

45-36/37/39-26

RTECS Number：

FD0575000

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (88.64%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

1-Phenylsemicarbazide Use and Manufacturing

Methods of Manufacturing

The preparation method is made by reacting phenylhydrazine and urea as raw materials. Add 136kg of phenylhydrazine hydrochloride, 98kg of urea and 240L of water into a 1000L reactor. Stir uniformly and raise the temperature to above 100°C for condensation reaction. After reacting for 6 hours, add 280L of water, cool to 5°C, and filter to obtain 1-phenyl semicarbazide with a content of 95% or more and a yield of 93% or more.

Uses

1-Phenyl semicarbazide is used to synthesize 1-phenyl-1,2,4-triazole alcohol, an intermediate of organophosphorus insecticide triazophos. In addition, it is also used to manufacture antipyretics in the pharmaceutical industry.

Manufacturing Info：

Hydrazinecarboxamide, 2-phenyl-: INACTIVE

Computed Properties

Molecular Weight:151.17
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.074561919
Monoisotopic Mass:151.074561919
Topological Polar Surface Area:67.2
Heavy Atom Count:11
Complexity:132
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1-Phenylsemicarbazide

QUANHUI BIO Contact Supplier

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1-PHENYLSEMICARBAZIDE

Unit Price: $100 /KG EXW

CAS No.: 103-03-7

Grade: Pharmaceutical Grade

Content: 99%

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