1-Phenylsemicarbazide
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1-Phenylsemicarbazide
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CAS No:
103-03-7
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Formula:
C7H9N3O
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Chemical Name:
1-Phenylsemicarbazide
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Synonyms:
Hydrazinecarboxamide,2-phenyl-;Semicarbazide,1-phenyl-;2-Phenylhydrazinecarboxamide;Cryogenine;Cryogenine (pharmaceutical);Phenylsemicarbazide;1-Phenylsemicarbazide;1-Carbamyl-2-phenylhydrazine;Phenicarbazide;Carbaphen;Febrimin;Phenicarbazid;Phenygenine;1-Carbamoyl-2-phenylhydrazine;Kryogenin;NSC 2763;(Phenylamino)urea
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CAS No:
1-Phenylsemicarbazide Basic Attributes
151.17
151.17
203-072-3
1LR2578324
2763
DTXSID9020245
29280090
Characteristics
67.2
1.84600
1.2100 (rough estimate)
172 °C
273.17°C (rough estimate)
1.5860 (estimate)
acetone: very soluble(lit.)
Peritoneal-mouse LD50: 198 mg/kg
Thermal decomposition to emit toxic nitrogen oxide fumes
Safety Information
NONH for all modes of transport
3
22
45-36/37/39-26
FD0575000
Xn
The warehouse is low-temperature, ventilated and dry
P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (88.64%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Phenylsemicarbazide Use and Manufacturing
The preparation method is made by reacting phenylhydrazine and urea as raw materials. Add 136kg of phenylhydrazine hydrochloride, 98kg of urea and 240L of water into a 1000L reactor. Stir uniformly and raise the temperature to above 100°C for condensation reaction. After reacting for 6 hours, add 280L of water, cool to 5°C, and filter to obtain 1-phenyl semicarbazide with a content of 95% or more and a yield of 93% or more.
1-Phenyl semicarbazide is used to synthesize 1-phenyl-1,2,4-triazole alcohol, an intermediate of organophosphorus insecticide triazophos. In addition, it is also used to manufacture antipyretics in the pharmaceutical industry.
Hydrazinecarboxamide, 2-phenyl-: INACTIVE
Computed Properties
Molecular Weight:151.17
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:151.074561919
Monoisotopic Mass:151.074561919
Topological Polar Surface Area:67.2
Heavy Atom Count:11
Complexity:132
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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