Gallein

Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent[1]. Gallein used as a red dye, an acid-base indicator and as a detection reagent for phosphates[2].

Gallein is a xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'. It has a role as a fluorochrome, a histological dye and a G-protein-coupled receptor antagonist. It is a gamma-lactone, a polyphenol, a xanthene dye, an oxaspiro compound, an organic heteropentacyclic compound and a member of 2-benzofurans. It derives from a fluoran.

Derived from the reaction of pyrogallol and phthalic anhydride. Slowly heat 148g of phthalic anhydride and 126g of pyrogallol. After liquefaction, continue to heat up to 190-200°C under stirring. After 4-5h, the reactant becomes thicker and thicker until it cannot be stirred. After cooling, wash the product with hot water, add 10% ammonium hydroxide solution to dissolve, and filter out insoluble matter. The filtrate was acidified with hydrochloric acid and a brown precipitate precipitated. Filter and wash with warm water. Recrystallize with ammonia water once to obtain about 100g of finished product.

Used as acid-base indicator, pH 3.8 (brown yellow)-6.6 (rose red); used as complex indicator, titrate bismuth and zirconium, and determine phosphate in urine. This product is bright red with tetravalent tin and is a sensitive reagent for determining tin.

Molecular Weight:364.3
XLogP3:2.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Exact Mass:364.05830272
Monoisotopic Mass:364.05830272
Topological Polar Surface Area:116
Heavy Atom Count:27
Complexity:579
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes