 Home > Encyclopedia > LOXO-101

LOXO-101

LOXO-101 structure

CAS No:
1223405-08-0
Formula:
C21H24F2N6O6S
Chemical Name:
LOXO-101
Synonyms:
Larotrectinib sulfate;LOXO-101 sulfate;ARRY-470 sulfate;UNII-RDF76R62ID;RDF76R62ID;(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide sulfate;(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate;Vitrakvi (TN);1-Pyrrolidinecarboxamide, N-(5-((2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxy-, (3S)-, sulfate (1:1);1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1)
Categories:
Biochemical Engineering > Biochemical Reagents

Description

Larotrectinib (LOXO-101) sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).

Larotrectinib Sulfate is the sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.

LOXO-101 Basic Attributes

Molecular Weight：

526.514

Exact Mass：

526.144592

UNII：

RDF76R62ID

NCI Thesaurus Code：

C156895

ATC Code：

L01XE53

Characteristics

PSA：

168.98000

XLogP3：

3.45140

Drug Information

Drug Indication：

Vitrakvi as monotherapy is indicated for the treatment of adult and paediatric patients with solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion,who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, andwho have no satisfactory treatment options.

LOXO-101 Use and Manufacturing

Use Classification：

Human drugs -> Vitrakvi -> EMA Drug Category|Antineoplastic agents -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:526.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:3
Exact Mass:526.14461000
Monoisotopic Mass:526.14461000
Topological Polar Surface Area:169
Heavy Atom Count:36
Complexity:741
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of LOXO-101

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Larotrectinib Sulfate cas 1223405-08-0

CAS No.: 1223405-08-0

Grade: Analytical Reagent

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

LOXO-101 (sulfate)

CAS No.: 1223405-08-0

Content: 99.00%

Inquiry
AnHui HaiKang Pharmaceutical CO.,LTD Contact Supplier

CN
9 YRS

Business licensed Certified factory

Manufactory Supplier of Imatinib mesylate

Loxo-101 99%

CAS No.: 1223405-08-0

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale Larotrectinib Sulfate 99% high quality see COA KANBEI

CAS No.: 1223405-08-0

Grade: Industrial Grade

Content: 99%

Inquiry
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of Peptides,API,Intermediate

Jinlan 98+ EP/BP/USP Larotrectinib sulfate

CAS No.: 1223405-08-0

Grade: medical grade

Content: 98%

Inquiry

Learn More Other Chemicals

2-Aminotetralin

2954-50-9
6-Carboxyfluorescein succinimidyl ester

92557-81-8
2-diphenylphosphanylphenol

60254-10-6
(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one Formula

79200-56-9
(1R)-2,2-Dimethylcyclopropanecarboxamide Formula

106462-18-4
Pyrrolidine, 3-fluoro-, hydrochloride (1:1), (3R)- Formula

136725-55-8
Benzeneacetyl chloride, α-amino-, hydrochloride (1:1), (αR)- Structure

39878-87-0
(+)-3-(Trifluoroacetyl)camphor Structure

51800-98-7
What is N-[2-(Diethylamino)ethyl]-2-propenamide

10595-45-6
What is (5R)-2,2,3-TRIMETHYL-5-PHENYLMETHYL-4-IMIDAZOLIDINONEMONOHYDROCHLORIDE

323196-43-6

Hot Searches: formula toluene; disodium pyrophosphate; sucrose acetate isobutyrate; vanadium nitride; keratolysis exfoliativa; baoh2

Guide of LOXO-101

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

LOXO-101

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.