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Cinnarizine

Cinnarizine structure

CAS No:
298-57-7
Formula:
C26H28N2
Chemical Name:
Cinnarizine
Synonyms:
Piperazine,1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-;Piperazine,1-cinnamyl-4-(diphenylmethyl)-;Piperazine,1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-;1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)piperazine;R 516;R 1575;N-Benzhydryl-N′-cinnamylpiperazine;1-Cinnamyl-4-(diphenylmethyl)piperazine;Cinnarizine;Dimitronal;1-Diphenylmethyl-4-cinnamoylpiperazine;Marisan;Midronal;Mitronal;Stugeron;Glanil;Labyrin;Dimitron;Stutgeron;Stutgin;Toliman;Folcodal;Sepan;1-Benzhydryl-4-cinnamylpiperazine;Lazeta;1-Cinnamyl-4-benzhydrylpiperazine;1-(3-Phenylallyl)-4-(diphenylmethyl)piperazine;Artate;Cinazyn;Apotomin;Corathiem;Cinaperazine;Katoseran;Giganten;Cerepar;Spaderizine;Cinnageron;Cerebolan;Hilactan;Cinnipirine;Denapol;Eglen;Carecin;Cinnacet;Sedatromin;Ixterol;Siptazin;Aplactan;Olamin;516MD;Processine;Aplexal;Cinarizine;Vergo;Stunarone
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Cinnarizine is an antihistamine and a calcium channel blocker, promote cerebral blood flow, used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.

Cinnarizine Basic Attributes

Molecular Weight：

368.51

Exact Mass：

368.51

EC Number：

206-064-8

HScode：

2933599090

Characteristics

PSA：

6.5

XLogP3：

5.8

Appearance：

white powder

Density：

1.13 g/cm³

Melting Point：

120.2 °C

Boiling Point：

505.8°C at 760 mmHg

Flash Point：

229.8±14.6 °C

Refractive Index：

1.626

Water Solubility：

soluble in chloroform at 50mg/ml

Storage Conditions：

Refrigerator

Vapor Pressure：

2.35E-10mmHg at 25°C

Toxicity：

LD50 oral in rat: > 6500mg/kg

Safety Information

Packing level：

Ⅲ

Transport codes：

3077

wgk germany：

hazard class code：

20/22-36/37/38-42/43

safety instructions：

22-24/25-36-26

RTECS Number：

TL3430000

Marks：

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

Cinnarizine Use and Manufacturing

Methods of Manufacturing

General procedure: General procedure for amination of allylic alcoholsAllylic alcohols 1 (0.4 mmol), Pd(Xantphos)Cl2 (0.02 mmol, 5 molpercent), amines 2(0.6 mmol) and 2-PrOH (1.5 mL) were added to a 25 mL flame-dried Young-typetube under nitrogen atmosphere. The mixture was stirred at room temperature for 12hrs. After concentrated under reduced pressure, the residue was purified by flashcolumn chromatography on silica gel and eluted with EtOAc/PE (1/100-1/1) to affordthe desired product 3.General procedure: Benzyltriphenyl phosphonium chloride (17.9 mmol) (prepared according to thereported procedure [31]) was added to a solution of 4a–c (17.0 mmol) in dichloromethane (50 ml) under N2 atmosphere. The mixture was cooled to 5 °C and t-BuOK (41.3 mmol) was added under stirring. After completion, the reaction mixture was quenched into water (100 ml). The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated under vacuum to obtain crude material 5a–c. The crude was then subjected to column purification over SiO2 using EtOAc/hexane as an eluent to afford 1a–c[25] and 6a–c in pure form.

Uses

For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.

Material

Tetrahydrofuran

Formaldehyde

Potassium carbonate

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Cinnarizine

Cinnarizine Capsules
Ingredients	The content of cinnarizine (C26H28N2) in this product should be 93.0% to 107.0% of the labeled amount.
Indication	1. When used in combination with alcohol, hypnotics or sedatives, the sedative effect is aggravated. 2. When used in combination with phenytoin sodium and carbamazepine, the blood concentration of cinnarizine can be reduced.
Specifications	25mg
Manufacturer	China Resources Zizhu Pharmaceutical Co., Ltd.

Cinnarizine Tablets
Ingredients	The main ingredient of this product is cinnarizine, and its chemical name is 1-diphenylmethyl-4-(3-phenyl-2-propenyl)-piperazine.
Indication	(1) When used in combination with alcohol, hypnotics or sedatives, the sedative effect is aggravated. (2) When used in combination with phenytoin sodium or carbamazepine, the blood concentration of cinnarizine can be reduced.
Specifications	25mg
Manufacturer	Tianjin Lisheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

FDC LTD

United States
Active
Jinyao Pharmaceutical Co., Ltd.

China
Active
Shanghai Modern Hasen (Shangqiu) Pharmaceutical Co., Ltd.

China
Active

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