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2-Amino-6-fluoropyridine

2-Amino-6-fluoropyridine structure

CAS No:
1597-32-6
Formula:
C5H5FN2
Chemical Name:
2-Amino-6-fluoropyridine
Synonyms:
6-Fluoropyridin-2-amine;2-AMINO-6-FLUOROPYRIDINE;6-FLUORO-PYRIDIN-2-YLAMINE;2-AMino-6-fluoropyriMidine;2-AMino-6-fluoropyridine,97+%;4''-ETHOXY-2,2,2-TRIFLUOROACETOPHENONE
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-Amino-6-fluoropyridine Basic Attributes

Molecular Weight：

112.11

Exact Mass：

112.043678

DSSTox ID：

DTXSID00375745

HScode：

2933399090

Characteristics

PSA：

38.9

XLogP3：

0.4

Density：

1.257±0.06 g/cm3(Predicted)

Melting Point：

59-61°C

Boiling Point：

225.0±20.0 °C(Predicted)

Flash Point：

89.9±21.8 °C

Refractive Index：

1.554

Storage Conditions：

Room temperature.

Vapor Pressure：

0.0165mmHg at 25°C

Safety Information

Hazard category：

6.1

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-22

safety instructions：

26-36/37/39

Marks：

Xi,Xn

Hazard note：

Irritant

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318-H335

GHS Classification：

|Danger|H302 (89.13%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Amino-6-fluoropyridine Use and Manufacturing

(4S)-Λ/-Methyl-Λ/-(f5-(4-methyl-1-piperazinvnimidazoπ .2-aloyridin-2- vπmethyl)-3, 4-dihvdro-2H-pyranof3, 2-b1pyridin-4-arnine EPO A solution of 2, 6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 mL, 28.0-30.0percent) was heated at 105A solution of 2, 6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 mL, 28.0-30.0percent) was heated at 105A solution of 2, 6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 ml_, 28.0-30.0percent) was heated at 1050C in a steel bomb for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with cold water, and dried to yield 6-fluoro-2-pyridinamine (45.8 g, 94percent yield) as a white solid. 1H-NMR (CDCI3): δ 7.53 (m, 1 H)1 6.36 (dd, 1 H), 6.26 (dd, 1 H), 4.56 (s, 2H).A solution of 2, 6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 mL, 28.0-30.0percent) was heated at 1052-(chloromethyl)-5-fluoroimidazoH , 2-alpyridine: 2, 6-difluoropyridine (31.5 ml_, 0.348 mol) was diluted with 30percent ammonium hydroxide(20OmL) in a steel bomb and heated to 110

Computed Properties

Molecular Weight:112.10
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:112.04367633
Monoisotopic Mass:112.04367633
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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