2,6-Dibromopyridine-4-carboxylicacid

Pale yellow solid

Synthesis of 2, 6-Dibromoisonicotinic Acid; [0114] Citrazinic acid (2.33 g, 0.015 moles) and phosphorous oxybromide were combined and heated to 180 °C under a nitrogen atmosphere for three hours. The cooled reaction was carefully quenched with ice-water. The mixture was filtered and the aqueous portion extracted with dichloromethane (4 x 40 ml). The solids were extracted in a Soxhlet extractor with dichloromethane for twelve hours. The organic portion from the direct extraction was dried over sodium sulfate, filtered, and stripped to give 2.2 g of reddish solid. The organic portion from the Soxhlet extraction was dried over sodium sulfate, filtered, and stripped to give 0.5 g of reddish solid. The two portions of 2, 6- dibromoisonicotinic acid (64 percent yield) were similar by NMR and were combined.'H NMR (CDC13) 8. 04 (2H, s).Synthesis of 2, 6-Dibromoisonicotinic Acid; [0114] Citrazinic acid (2.33 g, 0.015 moles) and phosphorous oxybromide were combined and heated to 180 C under a nitrogen atmosphere for three hours. The cooled reaction was carefully quenched with ice-water. The mixture was filtered and the aqueous portion extracted with dichloromethane (4 x 40 ml). The solids were extracted in a Soxhlet extractor with dichloromethane for twelve hours. The organic portion from the direct extraction was dried over sodium sulfate, filtered, and stripped to give 2.2 g of reddish solid. The organic portion from the Soxhlet extraction was dried over sodium sulfate, filtered, and stripped to give 0.5 g of reddish solid. The two portions of 2, 6- dibromoisonicotinic acid (64 % yield) were similar by NMR and were combined.'H NMR (CDC13) 8. 04 (2H, s).Add 50 g of

Molecular Weight:280.90
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:280.85100
Monoisotopic Mass:278.85305
Topological Polar Surface Area:50.2
Heavy Atom Count:11
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes