Thioflavin
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Thioflavin
structure -
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CAS No:
2390-54-7
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Formula:
C17H19N2S.Cl
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Chemical Name:
Thioflavin
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Synonyms:
Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride (1:1);Thioflavine T;Benzothiazolium,2-[p-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;2-[p-(Dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride;C.I. 49005;Acronol Lake Yellow T;Acronol Lake Yellow TC;Acronol Yellow T;Acronol Yellow TC;Basic Yellow T;Brilliant Flavine T;Citroflavine 8G;C.I. Basic Yellow 1;Kansai Basic Flavine 8GO;Methylene Yellow N;Methylene Yellow NI;Nankai Basic Flavine 8G;Primoflavine 8G;Setoflavine T;Tannoflavine T;Thioflavine;Thioflavine TCN;Thioflavine TCND;Thioflavine TG;Thioflavin T;Acronol Yellow TC 180;Setoflavin T;3,6-Dimethyl-2-dimethylaminophenylbenzothiazolium chloride;Rhoduline Yellow;Purimofurabin 8G;Basic yellow 1;Thioflavin TCN extra;Thioflavin TCN;Basic Flavine 8G;Thioflavin;Th-T;19: PN: US20130338076 SEQID: 187 claimed sequence;2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride
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CAS No:
Description
Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections.
Thioflavine T is an organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. It has a role as a fluorochrome and a histological dye. It contains a thioflavin T cation.
Characteristics
35.4
0.77120
Yellow to ochre-yellow Powder
211-212 °C (decomp)
methanol: soluble 1mg/mL
Store below +30°C.
Safety Information
III
6.1(b)
2811
3
24/25
Stable under normal temperatures and pressures.
P264, P270, P273, P280, P301+P310, P305+P351+P338, P310, P321, P330, P337+P313, P391, P405, P501
H301
|Danger|H301 (83.33%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P273, P280, P301+P310, P302+P352, P305+P351+P338, P310, P321, P330, P333+P313, P337+P313, P363, P391, P405, and P501|Aggregated GHS information provided by 8 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)
2-(p-(dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride
Thioflavin Use and Manufacturing
A benzothiazole dye, which can increase the fluorescence efficiency when connected to amyloid; used in histology and protein characterization
Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (1:1): ACTIVE
Computed Properties
Molecular Weight:318.9
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:318.0957475
Monoisotopic Mass:318.0957475
Topological Polar Surface Area:35.4
Heavy Atom Count:21
Complexity:325
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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