 Home > Encyclopedia > 3-Aminophthalimide

3-Aminophthalimide

3-Aminophthalimide structure

CAS No:
2518-24-3
Formula:
C8H6N2O2
Chemical Name:
3-Aminophthalimide
Synonyms:
1H-Isoindole-1,3(2H)-dione,4-amino-;Phthalimide,3-amino-;4-Amino-1H-isoindole-1,3(2H)-dione;3-Aminophthalimide;4-Amino-1,3-dioxo-2,3-dihydro-1H-isoindole;4-Amino-1H-isoindole-1,3(2H)-dione;4-Aminoisoindoline-1,3-dione
Categories:
Chemical Reagents > Organic Reagents

Request for Quotation

Description

yellow fine powder

3-Aminophthalimide Basic Attributes

Molecular Weight：

162.15

Exact Mass：

162.15

DSSTox ID：

DTXSID4062486

HScode：

2925190090

Characteristics

PSA：

72.2

XLogP3：

0.6

Density：

1.476 g/cm3

Melting Point：

268-269 °C

Refractive Index：

1.683

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

22-26-36/37-45

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H317-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

3-Aminophthalimide Use and Manufacturing

Methods of Manufacturing

3-Nitrophthalimide (LOOGR) was taken into a hydrogenation vessel and dissolved using 500ML of dimethylformamide. Raney nickel catalyst (20gr, wet) was added to the solution and subjected to hydrogenation conditions initially at 20-30°C UNDER 20-40psi. After the exothermic nature of the reaction was over, hydrogen pressure was increased to 40-60psi and the temperature to 40-50°C. After the hydrogen uptake is over sample was drawn from the reaction mass and checked for the absence of 3-nitrophthalimide by TLC. The reaction mixture was filtered while hot and the catalyst removed by filtration. Solvent was removed from the filtrate under reduced pressure at 60-80°C. Water (500ML) was added to the residue and the mixture stirred for 20-30MIN. The product was isolated by filtration and dried at 60-70°C to get a yellow crystalline solid of 3-aminophthalimide (80gr, 95percent). Melting point: 262-4°C.3-NITROPHTHALIMIDE (LOOGR) was taken into a hydrogenation kettle and dissolved using 500ML of dimethylformamide. 5percent Palladium/carbon (LOGR, 50percent wet) was added to the solution and subjected to hydrogenation conditions initially at 20-30°C under 20-40psi. After the exothermic nature of the reaction was over, hydrogen pressure was increased to 40-60psi and the temperature to 40-50°C. After the hydrogen uptake was over the reaction mixture was filtered while hot and the catalyst removed by filtration. Solvent was removed from the filtrate under reduced pressure at 60-80°C. Water (500ml) was added to the residue and the mixture stirred for 30min. The product was isolated by filtration and dried at 60-70°C to get 80GR (95percent) of yellow crystalline solid of 3- aminophthalimide. Melting point: 263-4°C.3-Nitrophthalimide (LOOGR) was taken into a beaker and dissolved using 200ML of dimethylformamide and 300ML of methanol. The solution was transferred into a 1L hydrogenation kettle and 20gr of Raney nickel was charged into the kettle. Hydrogenation was carried out initially at 20-40psi and 25-30°C until the exothermic nature was over. Hydrogenation was further continued at 40-60psi pressure and 40-50°C. After checking the completion of reaction by TLC catalyst was removed by filtration and the solvents distilled off from the reaction mixture at 50-60°C. The residue thus obtained was suspended in water (500ML) and filtered off to get a bright yellow crystalline compound of 3-aminophthalimide (78gr, 92.5percent). Melting point: 263-4°C

Manufacturing Info：

1H-Isoindole-1,3(2H)-dione, 4-amino-: INACTIVE

Computed Properties

Molecular Weight:162.15
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:162.042927438
Monoisotopic Mass:162.042927438
Topological Polar Surface Area:72.2
Heavy Atom Count:12
Complexity:239
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Aminophthalimide

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

3-Aminophthalimide

CAS No.: 2518-24-3

Content: 99.00%

Inquiry
Asia Chem I & E (Jiangsu) Co., Ltd Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of 3,5-Dinitrobenzoic acid,3,5-Din itrobenzoyl chloride,Sodium diatrizoate hydrate,Zinc-5-nitroisophthalate,3-Nitrophthalonitrile,4-Nitrophthalonitrile,Luminol (3-Aminophthalic hydrazide),3-Methyl-4-nitrobenzoic acid,3-Nitrophthalic acid,3-Nitrophthalimide,3-Nitrophthalic anhydride,Dimethyl 3-nitrophthalate,2-Methyl-6-nitro aniline,3-Nitrophthalhydrazide,4-Nitrophthalimide,4-Nitrophthalic acid,4-Nitrophthalic anhydride,4-Nitrosophenol,p-Benzoquinone dioxime,4-Methyl-3-nitrobenzoic acid,4-Chloro-3,5-dinitrobenzoic acid,Isobutyl 4-chloro-3,5-dinitrobenzoate,5-Nitroisophthalic acid,5-Aminoisophthalic acid,3,5-Diaminobenzoic acid,2-Chloro-5-nitrobenzoic acid,4-Chloro-3-nitrobenzoic acid,4-Nitro-N-methylphthalimide,Dimethyl 5-nitroisophthalate,Dimethyl 5-aminoisophthalate,3-Aminophthalimide,3-Methyl-2-nitrobenzoic acid,2-Amino-3-methylbenzoic acid,2-(4-Chloro-3-nitrobenzoyl) benzoic acid,2-(3-Amino-4-chlorobenzoyl)benzoic acid,3-Aminophthalic acid,4-Aminophthalic acid,3-Amino-4-methylbenzoic acid,4-Methyl-3-nitrobenzoate,Methyl 3-amino-4-methylbenzoate,Methyl 3-methyl-2-nitrobenzoate,3,5-Dinitrobenzonitrile,4-Aminophthalimide,4-Amino-N-methylphthalimide,3,5-Dinitrobenzamide

3-Aminophthalimide

CAS No.: 2518-24-3

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
JOXBIO Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of 5-Aminoisophthalic acid,3,3-Nitrophthalic anhydride,DNBC,Mono-Methyl 5-nitroisophthalate,5-DNBA,5-Dinitrobenzoyl chloride,6-triiodoisophthalic acid (5-Atipa),Formamidine Disulfide Dihydrochloride,5-dinitrobenzoic acid,3-Aminophthalic hydrazide,3-Nitrophthalic acid (3-NPA),3,2-(4-Chlorobenzoyl)benzoic acid,4-Nitrophthalonitrile,4-Nitrophthalimide,3-Nitrophthalonitrile,2-Methyl-4-nitroaniline,5-Dinitrobenzoic acid,DNBA,2-Methyl-6-nitroaniline,Sodium diatrizoate dihydrate,Pyridoxine dipalmitate,4-Nitro-N-methylphthalimide,Dimethyl 5-nitroisophthalate,4-Benzoquinone dioxime,5-DNBC,5-Nitroisophthalic acid,pyridoxine tripalmitate

3-Aminophthalimide

CAS No.: 2518-24-3

Grade: Pharmaceutical Grade

Content: 98.00%

Inquiry