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Sanguinarine

Sanguinarine structure

CAS No:
2447-54-3
Formula:
C20H14NO4
Chemical Name:
Sanguinarine
Synonyms:
[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-;Sanguinarine;13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;Pseudochelerythrine;Sanguinarin;Sanguinarium;Sangrovit;UI5;18203-15-1;857014-91-6;1265889-92-6
Categories:
Natural Products > Alkaloids

Description

Sanguinarine, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

Solid

Sanguinarine is a benzophenanthridine alkaloid, an alkaloid antibiotic and a botanical anti-fungal agent.

Sanguinarine Basic Attributes

Molecular Weight：

332.33

Exact Mass：

332.091736

EC Number：

219-503-3

UNII：

AV9VK043SS

DSSTox ID：

DTXSID0045204

Characteristics

PSA：

40.8

XLogP3：

3.42810

Appearance：

Solid

Density：

1.3463 (rough estimate)

Melting Point：

266 °C

Boiling Point：

483.53°C (rough estimate)

Refractive Index：

1.5180 (estimate)

Water Solubility：

3.316 mg/L @ 25 °C (est)

Toxicity：

LD50 oral in rat: 1660mg/kg

Safety Information

Transport codes：

1544

hazard class code：

safety instructions：

13-45

Drug Information

MeSH：

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

MeSH Entry Terms：

pseudo-chelerythrine

Computed Properties

Molecular Weight:332.3
XLogP3:4.4
Hydrogen Bond Acceptor Count:4
Exact Mass:332.09228293
Monoisotopic Mass:332.09228293
Topological Polar Surface Area:40.8
Heavy Atom Count:25
Formal Charge:1
Complexity:530
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Sanguinarine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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