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(+)-Catharanthine

(+)-Catharanthine structure

CAS No:
2468-21-5
Formula:
C21H24N2O2
Chemical Name:
(+)-Catharanthine
Synonyms:
Ibogamine-18-carboxylic acid,3,4-didehydro-,methyl ester,(2α,5β,6α,18β)-;Catharanthine;6,9-Methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole,ibogamine-18-carboxylic acid deriv.;(+)-Catharanthine;Catharanthine,(+)-;Catharanthin;(+)-3,4-Didehydrocoronaridine;47416-77-3
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.Target: nAChRCatharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/Ml [1]. Cathar

(+)-Catharanthine Basic Attributes

Molecular Weight：

336.43

Exact Mass：

336.43

EC Number：

219-586-6

Characteristics

PSA：

45.3

XLogP3：

3.11320

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Melting Point：

126-128 °C @ Solvent: Methanol

Boiling Point：

491.5°C at 760 mmHg

Flash Point：

251.1±28.7 °C

Refractive Index：

1.663

Water Solubility：

DMSO: soluble 5mg/mL (clear solution; warmed)

Storage Conditions：

-20°C

Vapor Pressure：

8.33E-10mmHg at 25°C

Toxicity：

Celiac-rat LD50:> 800 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Specific rotation：

D27 +29.8° (CHCl3)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Storage features：

The warehouse is low-temperature, ventilated and dry

Toxicity

Toxicity class：

practically nontoxic

(+)-Catharanthine Use and Manufacturing

Anticancer

Computed Properties

Molecular Weight:486.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:486.20021592
Monoisotopic Mass:486.20021592
Topological Polar Surface Area:160
Heavy Atom Count:35
Complexity:737
Defined Atom Stereocenter Count:3
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of (+)-Catharanthine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Recommended Suppliers
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(+)-Catharanthine

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