5-Ethyl-2-methylpyridine

121.18

121.18

109269

203-250-0

WG205CGK3Y

1772

1984

2300

DTXSID7021861

Colorless liquid

29333990

12.9

2.39

2-methyl-5-ethylpyridine appears as a colorless to yellow liquid. Insoluble in water and more dense than water. Hence sinks in water. Contact may slightly irritate the skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

0.9184 g/cm³ @ Temp: 23 °C

-70.9 °C

177.8 °C @ Press: 747 Torr

151 °F

n 20/D 1.497(lit.)

Practically insoluble in water

Store below +30°C.

Vapour pressure, kPa at 20°C: 0.191

4.2 (vs air)

Oral-rat LD50: 368 mg/kg; Oral-Mouse LD50: 282 mg/kg

Open flame is flammable; heated to decompose toxic nitrogen oxide gas

vol% in air: 1.1.6

Sharp, penetrating odor

pKa= 6.51 (conjugate acid)

WATER IS SOLUBLE IN LIQUID

Insoluble in water.

Amines, Phosphines, and Pyridines

2-METHYL-5-ETHYLPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. A mixture of nitric acid and methyl ethyl pyridine was placed in an autoclave and heated and stirred for 40 minutes. The emergency vent opened due to a sudden pressure rise, then an explosion occurred after about 90 seconds [Chem. Eng. News 30:3348. 1952].

939 °F (USCG, 1999)|939 °F|504 °C

Lower 1.1%, upper 6.6%

The vapour is heavier than air.

III

6.1

UN 2300 6.1/PG 3

3

20/22-34-20/21/22-52/53

26-36/37/39-45-61

TJ6825000

C,N

The warehouse is ventilated, low-temperature and dry; stored and transported separately from food materials and textiles

Corrosive

Stable. Hygroscopic. Combustible. Incompatible with strong oxidizing agents.

P261-P280-P305 + P351 + P338-P310

H302-H311 + H331-H314

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

... Can react vigorously with oxidizers. Potentially explosive reaction with nitric acid at 145 °C/ 14.5 bar.

Special Hazards of Combustion Products: Irritating vapors are generated when heated (USCG, 1999)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 68 °C explosive vapour/air mixtures may be formed. Gas/air mixtures are explosive.|Corrosives, Flammable - 2nd degree

|Danger|H302 (99.95%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P333+P313, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 1848 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P322, P330, P361, P363, P370+P378, P403+P233, P403+P235, P405, and P501|P201, P202, P210, P260, P264, P270, P280, P281, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P309+P311, P310, P312, P321, P322, P330, P361, P363, P370+P378, P403+P235, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)|Use dry powder, foam, carbon dioxide, water spray. In case of fire: keep drums, etc., cool by spraying with water.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Air-supplied mask for high vapor concentrations; plastic gloves; goggles or face shield. (USCG, 1999)|Depending on the extent of possible contact, workers should be provided with personal protective equipment. A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 l/min for 1 hr. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials ... . /Pyridine, homologs, and derivatives/

Flammable when exposed to heat or flame ... .

Explosive limits , vol% in air: 1.1-6.6

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.|/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Health: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.|/GUIDE 153: SUBSTANCES - TOXIC and/or CORROSIVE (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for 2-METHYL-5-ETHYLPYRIDINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Keep in a well-ventilated room. Store in an area without drain or sewer access. Separated from food and feedstuffs and strong oxidants.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the skin and eyes. The substance may be irritating to the respiratory tract.

NO open flames. Above 68 °C use a closed system and ventilation.

AVOID ALL CONTACT!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles or face shield.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

2-Methyl-5-ethylpyridine was detected in 1 of 21 industrial categories of wastewater effluents(1). Extract from the wastewater of an organic chemical manufacturer contained 2-methyl-5-ethylpyridine at an average concn of 3021 mg/l(1,2).

highly toxic

LD50 Rat oral 0.8-1.8 g/kg /From table/|LD50 Rat ip 0.2-0.4 g/kg /From table/|LD50 Mouse oral 0.8-1.6 g/kg /From table/|LD50 Mouse ip 0.1-0.2 g/kg /From table/|For more Non-Human Toxicity Values (Complete) data for 2-METHYL-5-ETHYLPYRIDINE (10 total), please visit the HSDB record page.

5-Ethyl-2-methyl-pyridine was found in peppermint oils.

2-Methyl-5-ethylpyridine's production and use in the manufacture of nicotinic acid and nicotinamide, and vinyl pyridines for copolymers, as an intermediate for germicides and textile finishes and as a corrosion inhibitor for chlorinated solvents(1) may result in its release to the environment through various waste streams(SRC). 2-Methyl-5-ethylpyridine is also released to the environment via effluents from oil processing facilities(2,3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that 2-methyl-5-ethylpyridine is expected to have moderate mobility in soil(SRC). 2-Methyl-5-ethylpyridine has a pKa of 6.51(5), which indicates that this compound will exist mainly in the protonated form in moist acidic and neutral soils, and cations adsorb more strongly to soils than neutral molecules. Therefore, the mobility of 2-methyl-5-ethylpyridine is expected to be much lower in acidic and neutral soils than in alkaline soils(SRC). Volatilization of the neutral species of 2-methyl-5-ethylpyridine from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-5 atm-cu m/mole(SRC), based upon its vapor pressure, 1.43 mm Hg(3), and water solubility, 12,000 mg/l(6). However, the protonated form will not volatilize(SRC). The potential for volatilization of 2-methyl-5-ethylpyridine from dry soil surfaces may exist(SRC) based upon its vapor pressure(3). Based on an aerobic column study using aquifer sediment, 2-methyl-5-ethylpyridine is expected to biodegrade slowly in soil. After 35 days of operation, only 43.4% of the initially applied 2-methyl-5-ethylpyridine was removed(4).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that 2-methyl-5-ethylpyridine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.9X10-5 atm-cu m/mole(SRC), based upon its vapor pressure, 1.43 mm Hg(4), and water solubility, 12,000 mg/l(9). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 and 20 days, respectively(SRC). However, the pKa of 2-methyl-5-ethylpyridine is 6.51(8), indicating this compound will exist in the ionized form in acidic and neutral waters and cations do not volatilize(SRC). According to a classification scheme(5), an estimated BCF of 14(SRC), from an estimated log Kow of 2.4(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on an aerobic column study using aquifer sediment, 2-methyl-5-ethylpyridine is expected to biodegrade slowly in water. After 35 days of operation, only 43.4% of the initially applied 2-methyl-5-ethylpyridine was removed(10).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-methyl-5-ethylpyridine, which has a vapor pressure of 1.43 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 2-methyl-5-ethylpyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 days(SRC), calculated from its rate constant of 2.4X10-12 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of 2-methyl-5-ethylpyridine with photochemically-produced hydroxyl radicals has been estimated as 2.4X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Methyl-5-ethylpyridine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). 3,5-Lutidine, a structurally-similar alkylated pyridine, has a weak absorption band that extends into the environmental UV spectrum(3), which suggests that direct photolysis is not likely to be an important fate process for alkylated pyridines (SRC). A pKa of 6.51(4) indicates 2-methyl-5-ethylpyridine will at least partially exist in the protonated form in acidic and neutral waters and soils.

An estimated BCF of 14 was calculated for 2-methyl-5-ethylpyridine(SRC), using an estimated log Kow of 2.4(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-methyl-5-ethylpyridine can be estimated to be 170(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-methyl-5-ethylpyridine is expected to have moderate mobility in soil. The pKa of 2-methyl-5-ethylpyridine is 6.51(3), which indicates that this compound will exist in the protonated form under acidic and neutral conditions. Cations adsorb more strongly to soil surfaces than neutral molecules thus adsorption of 2-methyl-5-ethylpyridine may be greater in acidic and neutral soils(SRC).

The Henry's Law constant for 2-methyl-5-ethylpyridine is estimated as 1.9X10-5 atm-cu m/mole(SRC) based upon its vapor pressure, 1.43 mm Hg(1), and water solubility, 12,000 mg/l(2). This Henry's Law constant indicates that 2-methyl-5-ethylpyridine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 2 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 20 days(SRC). 2-Methyl-5-ethylpyridine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). However, 2-methyl-5-ethylpyridine is a base with a pKa of 6.51(4), which indicates this compound will exist in the protonated form in acidic as well as neutral conditions; cations will not volatilize from either moist soil or water surfaces. The potential for volatilization of 2-methyl-5-ethylpyridine from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

DRINKING WATER: 2-Methyl-5-ethylpyridine was listed as a contaminant found in drinking water(1,2) for a survey of US cities including Pomona, Escondido, Lake Tahoe and Orange Co, CA and Dallas, Washington, DC, Cincinnati, Philadelphia, Miami, New Orleans, Ottumwa, IA, and Seattle(3).

2-Methyl-5-ethylpyridine was qualitatively identified as a volatile component of fried chicken(1) and mutton(3). 2-Methyl-5-ethylpyridine was tentatively identified in salt-fermented shrimp paste from Korea at a concentration of 140 ng/g(2). 5-Ethyl-2-methyl-pyridine was found in peppermint oils at unreported concentrations(4).

Primary routes of exposure would be skin/eye contact with liquid or inhalation of vapors.|Occupational exposure to 2-methyl-5-ethylpyridine may occur through inhalation and dermal contact with this compound at workplaces where 2-methyl-5-ethylpyridine is produced or used. Monitoring data indicate that the general population may be exposed to 2-methyl-5-ethylpyridine via ingestion of food and drinking water, and dermal contact with this compound and other products containing 2-methyl-5-ethylpyridine. (SRC)

PYRIDINE & ITS ALKYL DERIVATIVES ARE ABSORBED FROM GI TRACT, INTRAPERITONEAL CAVITY & LUNGS. PERITONEAL ABSORPTION IS APPARENTLY ONLY SLIGHTLY MORE RAPID & COMPLETE THAN GI ABSORPTION ... IN GENERAL THE BASES ARE RAPIDLY ABSORBED THROUGH INTACT SKIN. /ALKYL DERIVATIVES OF PYRIDINE/|MAJORITY OF /PYRIDINE/ DERIVATIVES TESTED ... PENETRATE INTACT GUINEA PIG SKIN READILY. AMINOPYRIDINES, VINYLPYRIDINES & 4-PICOLINE PENETRATE SKIN MOST RAPIDLY & AMYL DERIV & 5-ETHYL-2-METHYLPYRIDINE ARE LEAST READILY ABSORBED. /VINYLPYRIDINES/

Picolines and other substituted pyridines are by-products

Breathing of vapors will cause vomiting and chest discomfort. Contact with liquid causes skin and eye burns. (USCG, 1999)

INHALATION: remove victim to fresh air; give oxygen if breathing is difficult; call a physician. SKIN OR EYES: immediately flush with plenty of water for at least 15 min.; get medical care for eyes. (USCG, 1999)

Fresh air. Refer for medical attention.

Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aromatic hydrocarbons and related compounds/

2-methyl-5-ethylpyridine

The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

Cough. Sore throat.

Redness. Pain. Skin burns.

Redness. Pain.

Grade: Technical|Grades or Purity: 99.9%

Agriculture, forestry, fishing and hunting|Pyridine, 5-ethyl-2-methyl-: ACTIVE|Picolines and other substituted pyridines are byproducts.

RIGHT-ANGLE MATRIX IS DESCRIBED FOR INTERPRETING UV DATA ON 2-METHYL-5-ETHYLPYRIDINE, A PRECURSOR OF NICOTINIC ACID, BY SPECTROPHOTOMETRY.|NIOSH Method 1613. Analysis of air samples for pyridine using gas chromatography with FID detection. Working range of 1 to 14 ppm (3 to 45 mg/cu m) for a 100-L air sample /Pyridine/|Pyridine and its derivatives in water and sediment were determined by gas chromatography. Recovery was 95, 90, and 84% from purified water, river water, and sediment, respectively. The detection limit was 0.001 mg/l water and 0.01 mg/l sediment. /Pyridine and its derivatives/

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