5-Ethyl-2-methylpyridine Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | 5-ethyl-2-methylpyridine |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | 2-Picoline,5-ethyl; 5-Ethyl-2-Methylpyridine; 3-Ethyl-6-methylpyridine |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Food additives -> Flavoring Agents |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Skin sensitization, Sub-category 1B
Acute toxicity - Category 3, Inhalation
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H331 Toxic if inhaled H412 Harmful to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P317 If skin irritation or rash occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 5-ethyl-2-methylpyridine | 5-ethyl-2-methylpyridine | 104-90-5 | 203-250-0 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air. Refer for medical attention.
Following skin contact
Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.
Following eye contact
Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
Breathing of vapors will cause vomiting and chest discomfort. Contact with liquid causes skin and eye burns. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aromatic hydrocarbons and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Irritating vapors are generated when heated (USCG, 1999)
5.3 Special protective actions for fire-fighters
Use dry powder, foam, carbon dioxide, water spray. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Above 68°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Keep in a well-ventilated room. Store in an area without drain or sewer access. Separated from food and feedstuffs and strong oxidants.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or face shield.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. Clear. |
|---|---|
| Colour | Colourless. |
| Odour | Sharp, penetrating odor |
| Melting point/freezing point | -70.9 °C. Remarks:Pressure. |
| Boiling point or initial boiling point and boiling range | 178.3 °C. Atm. press.:1 013 hPa. |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | Lower 1.1%, upper 6.6% |
| Flash point | 64 °C. Atm. press.:1 007 mBar. |
| Auto-ignition temperature | 155 °C. Atm. press.:1 013.25 hPa. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Sol in alc, ether, benzene, dilute acids, concn sulfuric acid |
| Partition coefficient n-octanol/water | Pow = 127. Temperature:22 °C.;log Pow = 2.1. Temperature:22 °C. |
| Vapour pressure | 1.853 hPa. Temperature:20 °C. |
| Density and/or relative density | 0.921. Temperature:20 °C. |
| Relative vapour density | 4.2 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
On combustion, forms irritating and toxic fumes including nitrogen oxides and carbon monoxide. Reacts vigorously with strong oxidants. This generates fire and explosion hazard. Attacks copper and copper alloys.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
Flammable when exposed to heat or flame .The vapour is heavier than air.2-METHYL-5-ETHYLPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. A mixture of nitric acid and methyl ethyl pyridine was placed in an autoclave and heated and stirred for 40 minutes. The emergency vent opened due to a sudden pressure rise, then an explosion occurred after about 90 seconds [Chem. Eng. News 30:3348. 1952].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Can react vigorously with oxidizers. Potentially explosive reaction with nitric acid at 145 deg C/ 14.5 bar.
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke & irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 710 mg/kg bw.
- Inhalation: LC50 - rat (female) - 2.67 mg/L air.
- Dermal: LD50 - rabbit - 1 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the skin and eyes. The substance may be irritating to the respiratory tract.
STOT-repeated exposure
See Notes.
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - 55.6 - 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 39.6 mg/L - 48 h.
- Toxicity to algae: IC50 - Scenedesmus capricornutum - 61.2 mg/L - 72 h.
- Toxicity to microorganisms: NOEC - activated sludge - 38.8 mg/L - 18 h.
12.2 Persistence and degradability
BOD: (theoretical) 4.4%, 5 days; 56.6%, 20 days; 0.12-2.14 lb/lb, 5 days
12.3 Bioaccumulative potential
An estimated BCF of 14 was calculated for 2-methyl-5-ethylpyridine(SRC), using an estimated log Kow of 2.4(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-methyl-5-ethylpyridine can be estimated to be 170(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-methyl-5-ethylpyridine is expected to have moderate mobility in soil. The pKa of 2-methyl-5-ethylpyridine is 6.51(3), which indicates that this compound will exist in the protonated form under acidic and neutral conditions. Cations adsorb more strongly to soil surfaces than neutral molecules thus adsorption of 2-methyl-5-ethylpyridine may be greater in acidic and neutral soils(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2300 (For reference only, please check.) | IMDG: UN2300 (For reference only, please check.) | IATA: UN2300 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: 2-METHYL-5-ETHYLPYRIDINE (For reference only, please check.) | IMDG: 2-METHYL-5-ETHYLPYRIDINE (For reference only, please check.) | IATA: 2-METHYL-5-ETHYLPYRIDINE (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 5-ethyl-2-methylpyridine | 5-ethyl-2-methylpyridine | 104-90-5 | 203-250-0 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
5-Ethyl-2-methylpyridine is included in Heterocyclic Compound category.
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