 Home > Encyclopedia > 4-Hydroxybutyl acrylate

4-Hydroxybutyl acrylate

4-Hydroxybutyl acrylate structure

CAS No:
2478-10-6
Formula:
C7H12O3
Chemical Name:
4-Hydroxybutyl acrylate
Synonyms:
4-Hydroxybutyl acrylate ,98%;4-Hydroxybutyl acrylate, stabilized with ≈:500ppm 4-methoxyphenol;4-HYDROXYBUTYL ACRYLATE: TECH., 90%;4-HYDROXYBUTYL ACRYLATE STABILIZED 95+%;4-Hydroxybutyl acrylate, 95%, stab. with ca 500ppm 4-methoxyphenol;4-Hydroxybutyl Acrylate (stabilized with MEHQ);4-Hydroxybutyl acrylate, 96%, stabilized;1,4-Butanediol 1-acrylate
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

clear liquid

Liquid

4-Hydroxybutyl acrylate (HBA) can be synthesized by the esterification of acrylic acid with 1, 4 butanediol over a catalyst such as Amberlyst 15. 4-Hydroxybutyl acrylate (HBA) exhibits properties such as luster, chemical and scratch resistance. HBA monomers may be used as one of the constituents for the fabrication of a membrane system for controlled release of transdermal drug delivery system.

4-Hydroxybutyl acrylate Basic Attributes

Molecular Weight：

144.17

Exact Mass：

144.17

BRN：

1756545

EC Number：

219-606-3

UNII：

4O2A4HET1X

TSCA：

TSCA listed

DSSTox ID：

DTXSID3044623

Color/Form：

Colorless to Almost colorless

HScode：

29161290

Characteristics

PSA：

46.53000

XLogP3：

0.68

Appearance：

Liquid

Density：

1.041 g/mL at 25 °C (lit.)

Melting Point：

-112°C

Boiling Point：

95 °C/0.1 mmHg (lit.)

Flash Point：

86.6±15.4 °C

Refractive Index：

n20/D1.452(lit.)

Water Solubility：

soluble

Storage Conditions：

0-6ºC

Vapor Pressure：

0.5Pa at 20℃

Flammability characteristics：

Non flammable

PKA：

14.99±0.10(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

Packing level：

Hazard category：

Transport codes：

2922

wgk germany：

hazard class code：

Xn,N,Xi

safety instructions：

26-37/39-38-61-36/37/39-29

Marks：

Xi:Irritant;N:Dangerousfortheenvironment;

Storage features：

In order to prevent polymerization, 4-Hydroxybutyl Acrylate (4-HBA) must always be stored under air and never under inert gases. The presence of oxygen is required for the stabilizer to function effectively. In order to minimize the likelihood of overstorage, the storage procedure should strictly follow the “first-in-first-out” principle. For extended storage periods over 4 weeks, it is advisable to replenish the dissolved oxygen content. The storage temperature for 4-Hydroxybutyl Acrylate (4-HBA) should not exceed 25 °C. The preferred construction material for tanks and pipes is stainless steel. Carbon steel is also acceptable, although the formation of rust may be a problem with product quality (color). Iron(III)-ions are a weak polymerization initiator. If carbon steel is used, special procedures should be used to prepare the tank.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

20/21/22-36/37/38-51/53

RIDADR：

2922

GHS Classification：

|Danger|H302 (97.86%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 290 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Human Exposure：

ACGIH: TWA 5 mg/m3NIOSH: TWA 5 mg/m3

Drug Information

MeSH Entry Terms：

4-hydroxybutyl acrylate

4-Hydroxybutyl acrylate Use and Manufacturing

Uses

Intermediates

Hydroxybutyl acrylate was one of the monomers utilized in the preparation of poly(2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate, dibutyl maleate) membranes.

Manufacturing Info：

Paint and coating manufacturing|2-Propenoic acid, 4-hydroxybutyl ester: ACTIVE

Computed Properties

Molecular Weight:144.17
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:144.078644241
Monoisotopic Mass:144.078644241
Topological Polar Surface Area:46.5
Heavy Atom Count:10
Complexity:109
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Hydroxybutyl acrylate

SHANDONG LOOK CHEMICAL CO.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate,Pigment & Dyestuff,Polymer,Flavour & Fragrance,Basic Organic Chemicals,Pharmaceutical

High-Quality 4-Hydroxybutyl Acrylate CAS 2478-10-6

CAS No.: 2478-10-6

Content: 0.00%

Inquiry
Qingdao Orient Chemical Co.,LTD Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of pharmaceutical intermediates,peptides,electronic chemicals

4-Hydroxybutyl acrylate 2478-10-6

CAS No.: 2478-10-6

Grade: Industrail Grade

Content: 99%

Inquiry