N-(Phenylsulfonyl)benzenesulfonamide
-
N-(Phenylsulfonyl)benzenesulfonamide
structure -
-
CAS No:
2618-96-4
-
Formula:
C12H11NO4S2
-
Chemical Name:
N-(Phenylsulfonyl)benzenesulfonamide
-
Synonyms:
Benzenesulfonamide,N-(phenylsulfonyl)-;Dibenzenesulfonamide;N-(Phenylsulfonyl)benzenesulfonamide;Dibenzolsulfimide;Dibenzolsulfimid;Dibenzenesulfimide;Dibenzenesulfonic acid imide;Bis(phenylsulfonyl)amine;Dibenzenesulfonimide;Di(benzenesulfonyl)amine;Bis(phenylsulfonyl)imine;Bis(benzenesulfonyl)imide
- Categories:
-
CAS No:
N-(Phenylsulfonyl)benzenesulfonamide Basic Attributes
297.35
297.35
220-051-4
DTXSID0062557
2935009090
Safety Information
3
22-24/25
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
N-(Phenylsulfonyl)benzenesulfonamide Use and Manufacturing
A solventless grinding method for preparing bis-benzenesulfonimide, First 500 grams (3.185 mol) of benzenesulfonamide and 1009 grams were added(5.733 mol) of pure benzenesulfonyl chloride into a volume of 5Liter stainless steel ball mill for 5 minutes, The benzenesulfonamide and benzenesulfonyl chloride are thoroughly mixed at room temperature;Then in 5 times to the stainless steel ball mill 255 g (6.37 mol)Solid NaOH, the material after each addition of NaOH grinding 3 to 7 minutes, And keep the temperature of the reactants below 60 C for 15 minutes;After the reaction was completed, the reaction was transferred from the ball mill to a 5-liter three-necked flask, The reaction was added 10 times the mass of methylene chloride, Install the condenser, heating, stirring, reflux for 30 minutes, hot filtration, The solid in the funnel was washed three times with hot methylene chloride, The generated NaCl was filtered off and the filtrate was combined; Finally, the filtrate was concentrated under heating at atmospheric pressure, After evaporating 2/3 of the solvent, the remaining material was cooled at room temperature, After crystallization, filtration, to give a precipitate, The precipitate was dried at a temperature of 85 C, That is, bisbenzenesulfonimide product 879 grams, the yield was 93%Purity 98.0%.To a 500 ml flask was added 100 g of isopropanol, 50g of benzene sulfonamide dissolved in the preparation of sodium hydroxide, Isopropanol-sodium alcohol solution (14g isopropyl alcohol dissolved in 26g isopropyl alcohol), water bath temperature, while opening the mechanical stirring, When the temperature to 50-55 C, the solid is completely dissolved, began dropping benzenesulfonyl chloride 62g, while dropping sodium hydroxide, Isopropanol-sodium alcohol solution (28g isopropyl alcohol sodium dissolved in 52g isopropyl alcohol), control system pH value of 8 to 10, Control the rate of dropping, dropping finished in 50-55 C for 2h, through the hydroxide anion exchange resin.The reaction solution was cooled to 10 C and centrifuged to obtain BBI sodium salt. The sodium salt is dissolved in hot water, Crystals were precipitated by lowering the temperature by SAPPS cation exchange resin, and the crystals were vacuum dried at 40-50 C, To obtain 84.7 g of solid bis-benzenesulfonimide. As shown in Fig. 7, the results of the HPLC detection showed: benzenesulfonamide: 0.02%;Benzenesulfonyl chloride: 0.02%; NaCl: 0.08%; BBI: 99.96%; Yield: 89%.General procedure: A mixture of the appropriate arylsulfonyl chloride (11.2 mmol), the corresponding arylsulfonamide (12.3 mmol), DMAP (0.274 g, 2.24 mmol), and Et3N (1.95 mL, 14.0 mmol) in toluene (0.5 M) was kept at 70 C for 12 h (monitored by TLC). The reaction was quenched with aq 2 M HCl (30 mL) to pH 1. The mixture was extracted with EtOAc (3 × 20 mL) and the combined organic layers were dried (anhydrous MgSO4). The solvent was evaporated, and the crude product mixture was purified by recrystallization using hot CHCl3/hexane to afford the desired product.Benzenesulfonamide (50 g), acetonitrile (150 g) and triethylamine (97 g) were taken in a reaction vessel and stirred for 45 minutes. The benzene sulfonyl chloride (69 g) was added drop-wise to the reaction mixture at 20C. The reaction mixture was additionally stirred at 25C for 45 minutes. The acetonitrile was recovered by evaporation and solid reaction mass was dissolved in sodium hydroxide (20%, 300 g). The aqueous layer was separated, washed with chloroform and acidified with hydrochloric acid (35%) to obtain the title product. (0049) Yield (g): 90 (0050) Purity (% by HPLC): 99.2
Benzenesulfonamide, N-(phenylsulfonyl)-: ACTIVE
Computed Properties
Molecular Weight:297.4
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:297.01295018
Monoisotopic Mass:297.01295018
Topological Polar Surface Area:97.1
Heavy Atom Count:19
Complexity:429
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of N-(Phenylsulfonyl)benzenesulfonamide
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 2618-96-4Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
6 YRS
Business licensedDistributor Supplier of Perfluorinated surfactantsInquiryCAS No.: 2618-96-4Content: 90% -
![China]()
CN
9 YRS
Business licensed Certified factoryManufactory Supplier of electroplating intermediates, fine chemicals -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamine
Learn More Other Chemicals
-
Glycine, 1,1-dimethylethyl ester, compd. with N-(phenylsulfonyl)benzenesulfonamide (1:1)
77284-30-1
-
3-(3-CHLOROPROPYLCARBAMOYL)BENZENEBORONIC ACID
874288-10-5
-
3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester
58584-86-4
-
(+)-Mesembrenone Formula
468-54-2
-
1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-, hydrochloride (1:1) Formula
230615-52-8
-
(4-acetyloxyphenyl)-(4-acetyloxyphenyl)imino-oxidoazanium Formula
79030-44-7
-
1-(4-Methoxy-phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde Structure
347331-30-0
-
2,2'-DIAMINODIPHENYL SULFIDE Structure
5873-51-8
-
What is AC-ARG-PHE-MET-TRP-MET-ARG-NH2
152274-65-2
-
What is 1,1-Dimethylethyl 2-bromo-2-methylpropanoate
23877-12-5
N-(Phenylsulfonyl)benzenesulfonamide
SDSRequest for Quotation