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5-Chloro-2-thiophenesulfonyl chloride

5-Chloro-2-thiophenesulfonyl chloride structure

CAS No:
2766-74-7
Formula:
C4H2Cl2O2S2
Chemical Name:
5-Chloro-2-thiophenesulfonyl chloride
Synonyms:
2-Thiophenesulfonyl chloride,5-chloro-;5-Chloro-2-thiophenesulfonyl chloride;5-Chloro-2-thienylsulfonyl chloride;2-Chlorothiophene-5-sulfonyl chloride;2-Chloro-5-chlorosulfonylthiophene
Categories:
Chemical Reagents > Organic Reagents

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Description

5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid

5-Chloro-2-thiophenesulfonyl chloride Basic Attributes

Molecular Weight：

217.09

Exact Mass：

217.09

EC Number：

608-123-7

DSSTox ID：

DTXSID30370041

HScode：

2934999090

Characteristics

PSA：

70.8

XLogP3：

2.9

Appearance：

white to yellow crystalline low melting solid

Density：

1.7±0.1 g/cm3

Melting Point：

26-28 °C

Boiling Point：

74-76 °C

Flash Point：

133.8±23.2 °C

Refractive Index：

1.596

Water Solubility：

Not miscible in water.

Storage Conditions：

Keep Cold

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

3265

wgk germany：

hazard class code：

safety instructions：

S26-S27-S36/37/39-S45-S28A-S25

Marks：

C:Corrosive

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H314

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 46 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-Chloro-2-thiophenesulfonyl chloride Use and Manufacturing

Methods of Manufacturing

The following procedure was adapted from C. A. Hunt, et al. J. Med. Chem. 1994, 37, 240-247. In a three-necked R.B. flask, equipped with a mechanical stirrer, an air condenser, a dropping funnel, and a moisture-guard tube, was placed chlorosulfonic acid (240 mL, 3.594 mol). Under stirring, PClSynthesis of the intermediate sulfonylurea carbamate (8)Step 1 - Preparation 5-chlorothiophene-2-sulfonyl chloride:

Uses

5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease.

Computed Properties

Molecular Weight:217.1
XLogP3:2.9
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:215.8873270
Monoisotopic Mass:215.8873270
Topological Polar Surface Area:70.8
Heavy Atom Count:10
Complexity:208
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Chlorosulfonic acid

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5-Chlorothiophene-2-sulfonyl chloride

CAS No.: 2766-74-7

Grade: industrial Grade

Content: 98%

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CAS No.: 2766-74-7

Grade: Industrial Grade

Content: 99%

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Guide of 5-Chloro-2-thiophenesulfonyl chloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
Latest News
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5-Chloro-2-thiophenesulfonyl chloride

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