Pigment Red 4

327.72

327.72

220-562-2

OE8ZA0KN9Z

DTXSID7044637

Intense yellowish red

2928000090

87.3

6.55 (est)

Liquid

1.45 g/cm3

276 deg C

496.7ºC at 760 mmHg

254.2ºC

1.684

In water, 0.03 mg/L at 25 deg C (est)

1.55X10-10 mm Hg at 25 deg C (est)

Combustible, decomposes toxic chloride, nitrogen oxide gas when burning

Henry's Law constant = 9.3X10-13 atm-cu m/mole at 25 °C (est)

36

26

QL3436000

Xi

Warehouse low temperature, ventilated, dry

P264, P273, P280, P305+P351+P338, P337+P313, P501

H319

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

All batches of this color additive when used for drugs shall meet the specifications, uses and restrictions, and labeling regulations contained in 21 CFR Part 74 and be certified in accordance with regulations in 21 CFR Part 80.

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, and P501|Aggregated GHS information provided by 322 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

C.I. Pigment Red 4's production and use in cosmetic lip products(1), printing inks(2), and limited use as a drug colorant(3) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 2.3X10+5(SRC), determined from a structure estimation method(2), indicates that C.I. Pigment Red 4 is expected to be immobile in soil(SRC). Volatilization of C.I. Pigment Red 4 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.3X10-13 atm-cu m/mole(SRC), using a fragment constant estimation method(3). C.I. Pigment Red 4 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.6X10-10 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2009).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 2.3X10+5(SRC), determined from a structure estimation method(2), indicates that C.I. Pigment Red 4 is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.3X10-13 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 10(SRC), from an estimated log Kow of 6.6(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2009).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), C.I. Pigment Red 4, which has an estimated vapor pressure of 1.6X10-10 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Pigment Red 4 may be removed from the air by wet or dry deposition(SRC). C.I. Pigment Red 4 contains functional groups that are typically chromophores which absorb at wavelengths >290 nm(3); therefore C.I. Pigment Red 4 may be susceptible to direct photolysis by sunlight(SRC).

C.I. Pigment Red 4 is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(1). C.I. Pigment Red 4 contains functional groups which are typically chromophores that absorb at wavelengths >290 nm(1); therefore C.I. Pigment Red 4 may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 10 was calculated for C.I. Pigment Red 4(SRC), using an estimated log Kow of 6.6(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of C.I. Pigment Red 4 can be estimated to be 2.3X10+5(SRC). According to a classification scheme(2), this estimated Koc value suggests that C.I. Pigment Red 4 is expected to be immobile in soil.

The Henry's Law constant for C.I. Pigment Red 4 is estimated as 9.3X10-13 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that pigment red 4 is expected to be essentially nonvolatile from water surfaces(2). The Henry's Law constant of C.I. Pigment Red 4 indicates that volatilization from moist soil surfaces is not expected(SRC). C.I. Pigment Red 4 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.6X10-10 mm Hg(SRC), determined from a fragment constant method(3).

Occupational exposure to C.I. Pigment Red 4 may occur through inhalation of dust and dermal contact with this compound at workplaces where C.I. Pigment Red 4 is produced or used. Use data indicate that the general population may be exposed to C.I. Pigment Red 4 via dermal contact with consumer products and ingestion of limited drugs containing this compound. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

1-((2-chloro-4-nitrophenyl)azo)-2-naphthol

Synthetic dye and pigment manufacturing|2-Naphthalenol, 1-[2-(2-chloro-4-nitrophenyl)diazenyl]-: ACTIVE|The color additive D&C Red No. 36 /Pigment Red 4/ may be safely used for coloring ingested drugs, other than mouthwashes and dentifrices, in amounts not to exceed 1.7 mg/daily dose of the drug for drugs that are taken continuously only less than 1 year. For drugs taken continuously for longer than 1 year, the color additive shall not be used for amounts to exceed 1.0 mg/daily dose of the drug. /Pigment Red 4/ may be safely used for coloring externally applied drugs in amounts consistent with current good manufacturing practice.|Pigment is not used in foods as it is prohibited by the FDA.|... Show poor bleed and bake resistance and a tendency to bloom in enamels. use... has declined markedly as a result of greater quality demands by the coatings industry

Cosmetics -> Cosmetic colorant; Hair dyeing