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TYRPHOSTINA1

TYRPHOSTINA1 structure

CAS No:
2826-26-8
Formula:
C11H8N2O
Chemical Name:
TYRPHOSTINA1
Synonyms:
AG9;TYRPHOSTINA;TYRPHOSTIN1;TYRPHOSTINA1;TYRPHOSTINAG9;AKOSUSSH-4110227;TYRPHOSTINA199+%;RARECHEMALBX0083;4-METHOXYBENZLIDENEMALONONITRILE;(4-METHOXYBENZYLIDENE)MALONITRILE
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.IC50 value: Target: IL-12 production inhibitorAddition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decreas

2-[(4-methoxyphenyl)methylidene]propanedinitrile is a member of methoxybenzenes.

TYRPHOSTINA1 Basic Attributes

Molecular Weight：

184.19400

Exact Mass：

184.06400

NSC Number：

637326|1343

DSSTox ID：

DTXSID10182508

HScode：

2926909090

Characteristics

PSA：

56.81000

XLogP3：

2.12576

Density：

1.169g/cm3

Melting Point：

113-116ºC(lit.)

Boiling Point：

352.4ºC at 760mmHg

Flash Point：

148.8ºC

Refractive Index：

1.589

Safety Information

Packing level：

III

Transport codes：

UN 3439 6.1/PG III

wgk germany：

hazard class code：

20/21/22

safety instructions：

36/37

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

(3,4-dihydroxybenzylidene)malononitrile

Computed Properties

Molecular Weight:184.19
XLogP3:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:184.063662883
Monoisotopic Mass:184.063662883
Topological Polar Surface Area:56.8
Heavy Atom Count:14
Complexity:289
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes