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Bromotrimethylsilane

Bromotrimethylsilane structure

CAS No:
2857-97-8
Formula:
C3H9BrSi
Chemical Name:
Bromotrimethylsilane
Synonyms:
Silane,bromotrimethyl-;Bromotrimethylsilane;Trimethylsilyl bromide;Trimethylbromosilane;Trimethylsilicon bromide;NSC 139857;TMSBr
Categories:
Chemical Reagents > Organic Reagents

Description

Clear yellow liquid

Bromotrimethylsilane is used as a reagent in the synthesis of α-carboxy nucleoside phosphonate analogs as HIV reverse transcriptase-targeting agents.

Bromotrimethylsilane Basic Attributes

Molecular Weight：

153.09

Exact Mass：

153.09

BRN：

1731135

EC Number：

220-672-0

UNII：

JHH5G299BX

NSC Number：

139857

DSSTox ID：

DTXSID1062671

HScode：

2933990090

Characteristics

PSA：

XLogP3：

2.2162

Appearance：

Clear colorless to yellow Liquid

Density：

1.172 g/cm³

Melting Point：

-44 °C

Boiling Point：

80 °C

Flash Point：

90 °F

Refractive Index：

1.42-1.425

Water Solubility：

DECOMPOSES

Storage Conditions：

2-8°C

Vapor Pressure：

100mmHg at 25°C

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

UN 2920 8/PG 2

wgk germany：

hazard class code：

10-34-29-14

safety instructions：

16-26-36/37/39-45-8

Marks：

Stability/Shelf Life：

Stable. Flammable. Incompatible with strong acids, strong oxidizing agents. May decompose on exposure to water or moist air.

Precautionary statement(s)：

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P370+P378, P403+P235, P405, P501

Hazard Statements：

H225

RIDADR：

UN 2920

GHS Classification：

|Danger|H225 (16.98%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P370+P378, P403+P235, P405, and P501|Aggregated GHS information provided by 53 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

bromotrimethylsilane

Bromotrimethylsilane Use and Manufacturing

Methods of Manufacturing

Phenyltrimethylsilane is obtained by bromination.

Uses

Powerful silylating agent

Manufacturing Info：

Silane, bromotrimethyl-: ACTIVE

Analysis Methods

Name	Column Shape	Active Phase(℃)	Retention index	Temperature Control	Method	Comments	Reference
Normal alkane RI, non-polar column, custom temperature program	Capillary	Methyl Silicone	641.		custom temperature program	Program: not specified	Zenkevich, I.G.Comparative Characterization of Conditions for Unambuguous Chromatographic Identification of Organic CompoundsZh. Anal. Khim.2001, 56, 9, 915-924.

Computed Properties

Molecular Weight:153.09
Exact Mass:151.96569
Monoisotopic Mass:151.96569
Heavy Atom Count:5
Complexity:28.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

62012-16-2

38325-58-5

96861-35-7

30718-20-8

7312-06-3

Material

Hexamethyldisiloxane

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