3-Heptanone

114.19

114.19

506161

203-388-1

10GA6SR3AT

0889

8448

1224

DTXSID2047438

Clear liquid|Colorless liquid

29141990

17.1

1.73 (est)

Clear slightly yellow Liquid

0.8183 g/cm³ @ Temp: 20 °C

-39 °C

147 °C @ Press: 765 Torr

106 °F

n 20/D 1.408(lit.)

H2O: 3.3 g/L (20 ºC)

Flammables area

Vapour pressure, Pa at 25°C: 187

Relative vapour density (air = 1): 3.9

Oral-Rat LD50: 2760 mg/kg

In case of fire, high temperature, oxidant is more flammable; burning produces irritating smoke

1.4% and 8,8% by volume in air

GREEN ODOR

MELON, BANANA FLAVOR

Henry's Law constant = 9.08X10-5 atm-cu m/mole at 20 °C (est).

Air pollution factors: 1 mg/cu m = 0.214 ppm, 1 ppm = 4.66 mg/cu m|Ionization Potential, 9.02 eV|Hydroxyl radical reaction rate constant = 7.89X10-12 cu cm/molec-sec at 25 °C (est)

Flammable.

Ketones

Highly Flammable

ETHYL BUTYL KETONE is reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. May react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. Irritating vapors and toxic gases may be formed when involved in fire (USCG, 1999).

3-Heptanone|D*: Other compounds that may form peroxides|1 samples, 2 ppm Peroxide; > 1 yr|Management of time-sensitive chemicals (JCHAS)

9.02 eV

Lower flammable limit: 1.4% by volume; Upper flammable limit: 8.8% by volume|Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

36.61 kJ/mol at 101.3 kPa

III

3

UN 2810 6.1/PG 3

2

22-38-40-48/20/22-36-20-10

36-24-36/37-24/25

MJ5250000

Xn,Xi

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Irritant

Explosive when mixed with air

Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. May form peroxides in storage if in contact with air - store under inert gas.

P305 + P351 + P338

H226-H319-H332

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|LARGE QUANTITIES CAN BE COLLECTED & ATOMIZED IN SUITABLE COMBUSTION CHAMBER EQUIPPED WITH AN APPROPRIATE EFFLUENT GAS CLEANING DEVICE. ETHYL BUTYL KETONE SHOULD NOT BE ALLOWED TO ENTER A CONFINED SPACE SUCH AS A SEWER, BECAUSE OF POSSIBILITY OF EXPLOSION.|Spray into a furnace. Incineration will become easier by mixing with a more flammable solvent.

Forms explosive mixture with air. Violent reaction with strong oxidizers, acetaldehyde, perchloric acid. Attacks some plastics, rubber, and coatings.|Oxidizers, acetaldehyde, perchloric acid.

3-Heptanone is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire. (USCG, 1999)|Flammable. Above 46 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Warning|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P235, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|Aggregated GHS information provided by 1733 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P331, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Fire Extinguishing Agents Not to Be Used: Water. Fire Extinguishing Agents: Dry chemical, alcohol foam, or carbon dioxide. (USCG, 1999)|Use powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Ventilation, local exhaust, or breathing protection. Protective gloves. Safety goggles.|Appropriate protective equipment and good industrial hygiene practices should preclude injury to the skin and eyes, and the low volatility of ethyl n-butyl ketone should prevent injury due to inhalation of the vapors.|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|For more Personal Protective Equipment (PPE) (Complete) data for 3-HEPTANONE (8 total), please visit the HSDB record page.|(See protection codes)

PROBLEM OF FLAMMABILITY SHOULD NOT BE GREAT UNLESS MATERIAL IS HANDLED @ ELEVATED TEMP.|BEFORE HEAT IS APPLIED FOR PURPOSE OF WELDING OR CUTTING A VESSEL THAT HAS CONTAINED KETONES, THE VESSEL SHOULD BE EMPTIED & PURGED TO REMOVE EVERY TRACE OF FLAMMABLE MATERIAL.

1.4% and 8,8% by volume in air

1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN SAFE PLACE (SUCH AS FUME HOOD). ALLOW ... EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS.|Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or similar material and deposit in sealed containers. Keep ethyl butyl ketone out of a confined space ... because of the possibility of an explosion ... It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.|Absorb on paper. Evaporate on a glass or iron dish in hood. Burn the paper.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Do not eat, drink, or smoke during work. Wash hands before eating.|Work practices and industrial hygiene techniques should minimize the volatilization of ketones in the workroom air in order to ensure that the exposure limits are not exceeded. /Ketones/|For more Preventive Measures (Complete) data for 3-HEPTANONE (6 total), please visit the HSDB record page.

Mild irritation - eye, nose, throat, skin

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 50 ppm (230 mg/cu m).

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 50 ppm (230 mg/cu m).

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable metal containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

Fireproof.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure could cause lowering of consciousness.

Repeated or prolonged contact with skin may cause dermatitis.

NO open flames, NO sparks and NO smoking. Above 46 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

3-Heptanone was qualitatively identified in advanced waste treatment water from Pomona, CA in October of 1974(1). 3-Heptanone was qualitatively identified in effluents from one Illinois Publicly Owned Treatment Work (POTW)(2). 3-Heptanone was qualitatively detected in raw effluent from a textile finishing plant(3). A section of a polyethylene pipe commonly used for distribution of drinking water was soaked in mineral water for 48 hours and 3-heptanone was qualitatively identified in the water(4).

RURAL/REMOTE: 3-Heptanone was qualitatively identified in air samples from a 45 year old spruce forest in Germany on January 11, 1988 at a height of 1 m(1).

A German study in 1990 and 1991 of 113 people (ages 25-69), chosen from a group of 2500 to represent the population, gave personal atmospheric exposure to 3-heptanone in 53 samples an average of 1.7 ug/cu m and 60 samples were less than 0.7 ug/cu m(1).

moderately toxic

... Large multiple doses (1.5 g/kg/day, 5 days/week, 14 weeks) of methyl ethyl ketone (MEK) given by gavage potentiated EBK (2 g/kg/day, 5 days/week for 14 weeks) neurotoxicity but 5-methyl-2-octanone did not. MEK modestly increased the urinary excretion of two neurotoxic gamma-diketones, 2,5-heptanedione, and 2,5-hexanedione, when MEK was given by gavage with EBK. When rats were exposed to EBK (700 ppm) and MEK (700 or 1400 ppm) in combination by inhalation exposure, serum 2,5-heptanedione levels were increased approximately 2.5 times. This effect was absent at MEK levels of 70 ppm. The serum from rats exposed to EBK or EBK/MEK combinations did not contain 2,5-hexanedione. ...

LD50 Rabbit skin >20 mL/kg/24 hr|LD50 Rat oral 2760 mg/kg

3-Heptanone is released in emissions from forests(1).

3-Heptanone's production and use as a solvent for polyvinyl and nitrocellulose resins(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 44(SRC), determined from a water solubility of 4,300 mg/L(2) and a regression-derived equation(3), indicates that 3-heptanone is expected to have very high mobility in soil(SRC). Volatilization of 3-heptanone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.1X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 2.6 mm Hg(4) and its water solubility(2). 3-Heptanone is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Biodegradation of 3-heptanone may be expected based upon screeening aqueous biodegradation tests(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 44(SRC), determined from a water solubility of 4,300 mg/L(2) and a regression-derived equation(3), indicates that 3-heptanone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 9.1X10-5 atm-cu m/mole(SRC), derived from its vapor pressure, 2.6 mm Hg(4) and its water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 13 hours and 7.4 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 6(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation of 3-heptanone may be expected based upon screeening aqueous biodegradation tests(6).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-heptanone, which has a vapor pressure of 2.6 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3-heptanone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 days(SRC), calculated from its rate constant of 7.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 3-Heptanone contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of 3-heptanone with photochemically-produced hydroxyl radicals has been estimated as 7.9X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 2 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 3-Heptanone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 3-Heptanone contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight(2).

An estimated BCF of 6 was calculated in fish for 3-heptanone(SRC), using a water solubility of 4,300 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 3-heptanone is estimated as 44(SRC), using a water solubility of 4,300 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 3-heptanone is expected to have very high mobility in soil.

The Henry's Law constant for 3-heptanone is estimated as 9.1X10-5 atm-cu m/mole(SRC) derived from its vapor pressure, 2.6 mm Hg(1), and water solubility, 4,300 mg/L(2). This Henry's Law constant indicates that 3-heptanone is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 13 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 7.4 days(SRC). 3-Heptanone's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 3-heptanone from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

DRINKING WATER: 3-Heptanone was qualitatively detected in drinking water samples collected from treatment facilities in Cincinnati, OH (Jan 14, 1980), Miami, FL (Feb 3, 1976), Ottumwa, IA (Sep 10, 1976), and Seattle, WA (November 5, 1976)(1).

3-Heptanone is a volatile constituent of beef flavor(1) and frankfurters(2).

In a pilot study of pollutants in the breast milk of women living in 4 urban industrial areas in the USA, 3-heptanone was qualitatively identified in 4 of 12 samples(1). 3-Heptanone was found in 1 of 6, 1 of 5, and 2 of 12 breast milk samples from women living in Bayonne, NJ, Jersey City, NJ and Pittsburgh, PA, respectively(2). None of the 10 Baton Rouge, LA or 9 Charleston, WV breast milk samples contained 3-heptanone(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 11,320 workers (1,164 of these are female) are potentially exposed to 3-heptanone in the US(1). Occupational exposure to 3-heptanone may occur through inhalation and dermal contact with this compound at workplaces where 3-heptanone is produced or used. Monitoring data indicate that the general population may be exposed to 3-heptanone via inhalation of ambient air and via ingestion of food and drinking water(SRC).|IN INDUSTRIAL HANDLING, PRINCIPAL SOURCES OF EXPOSURE ARE THOSE OF INHALATION OF VAPORS & SKIN & EYE CONTACT.|EXPOSURE /TO N-BUTYL ETHYL KETONE/ IN THE INDUSTRIAL SETTING WOULD BE PRINCIPALLY BY INHALATION & BY SKIN & EYE CONTACT.

In a pilot study of pollutants in the breast milk of women living in 4 urban industrial areas in the USA, 3-heptanone was qualitatively identified in 4 of 12 samples(1). 3-Heptanone was found in 1 of 6, 1 of 5, and 2 of 12 breast milk samples from women living in Bayonne, NJ, Jersey City, NJ and Pittsburgh, PA, respectively(2). None of the 10 Baton Rouge, LA or 9 Charleston, WV breast milk samples contained 3-heptanone(2). 3-Heptanone was identified, not quantified in human urine samples(3).

... The toxicity of EBK appears to involve the metabolism of EBK to two neurotoxic gamma-diketones, 2,5-heptanedione and 2,5-hexanedione. Combined EBK/MEK exposure modestly increased gamma-diketone levels in the serum and urine suggesting that MEK potentiates EBK neurotoxicity by stimulating the metabolism of EBK to neurotoxic metabolites. ...|Ethyl n-Butyl ketone (EnBK) may be metabolized by rats to 2,5-heptanedione, which, like its six-carbon counterpart, 2,5-hexanedione, has been shown to be neurotoxic. However, repeated inhalation exposures to high concentrations of EnBK failed to produce serum levels of 2,5-heptanedione high enough to produce neuropathy in rats.|Urinary metabolites of n-heptane following exposure to n-heptane or to technical heptane were identifiable in male Sprague Dawley rats ... Rats were exposed to 1,800 ppm n-heptane for 6 hr. Urine and feces were collected for 24 hr after treatment. ... In rats, 2-heptanol and 3-heptanol were the main biotransformation products of the solvent. 2-Heptanone, 3-heptanone, 4-heptanol, 2,5-heptanedione, valerolactone, 2-ethyl-5-methyl-2,3-dihydrofuran, and 2,6-dimethyl-2,5-dihydropyran were also found as metabolites of n-heptane. ...

Short term exposure can cause irritation of eyes, nose, throat and lungs. High concentrations may cause headache, dizziness or unconsciousness. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, flush the contaminated skin with water. Where there is evidence of skin irritation, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

INHALATION. Symptoms: Cough. Dizziness. Headache. Sore throat. Unconsciousness. First aid: Fresh air, rest. Refer for medical attention. SKIN: Symptoms: Dry skin. Redness. First aid: Remove contaminated clothes. Rinse skin with plenty of water or shower. EYES: Symptoms: Redness. Pain. First aid: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: First aid: Rinse mouth. Rest. Refer for medical attention.|Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . For contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ketones and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ketones and related compounds/

/SIGNS AND SYMPTOMS/ ACUTE LOCAL: IRRITANT 2. ACUTE SYSTEMIC: INGESTION 2; INHALATION 2. 2= MODERATE: MAY INVOLVE BOTH IRREVERSIBLE & REVERSIBLE CHANGES NOT SEVERE ENOUGH TO CAUSE DEATH OR PERMANENT INJURY.|/SIGNS AND SYMPTOMS/ Nervous system disturbances - /SRP: CNS Depression/|/SIGNS AND SYMPTOMS/ Harmful effects and symptoms: ... headaches ... coma; dermatitis.

3-heptanone

The substance can be absorbed into the body by inhalation of its vapour.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, mucous membrane; headache, narcosis, coma; dermatitis

Cough. Dizziness. Headache. Sore throat. Unconsciousness.

Dry skin. Redness.

Redness. Pain.

Eyes, skin, respiratory system, central nervous system

3-Heptanone: ACTIVE|PURITY: 95%.|FEMA NUMBER 2545

Method: NIOSH 2553, Issue 1; Procedure: gas chromatography with flame ionization detector; Analyte: 3-heptanone; Matrix: air; Detection Limit: 0.07 ug/sample.|Method: NIOSH 1301, Issue 2; Procedure: gas chromatography with flame ionization detector; Analyte: 3-heptanone; Matrix: air; Detection Limit: 0.05 mg/sample.|Analyte: 3-heptanone; matrix: air; procedure: atmospheric sampling Townsend discharge ionization mass spectrometry

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index|Fatty Acyls [FA] -> Oxygenated hydrocarbons [FA12]|Fire Hazards -> Flammable - 2nd degree

Flavoring Agents