D-Methionine
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D-Methionine
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CAS No:
348-67-4
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Formula:
C5H11NO2S
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Chemical Name:
D-Methionine
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Synonyms:
D-Methionine;Methionine,D-;(R)-Methionine;NSC 45689;S-Methyl-D-homocysteine;MRX 1024;(R)-2-Amino-4-(methylthio)butanoic acid;(2R)-2-Amino-4-methylsulfanylbutanoic acid
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CAS No:
Description
Methionine (MRX-1024) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
D-methionine is an optically active form of methionine having D-configuration. It is a methionine and a D-alpha-amino acid. It is a conjugate base of a D-methioninium. It is a conjugate acid of a D-methioninate. It is an enantiomer of a L-methionine. It is a tautomer of a D-methionine zwitterion.|A sulfur-containing essential L-amino acid that is important in many body functions.
Characteristics
88.6
-1.9
White to off-white Powder
1.2±0.1 g/cm3
100-101 °C
181 deg C (decomposes)
139.4±26.5 °C
1.531
H2O: 53 g/L (20 ºC)
0-6°C
8.14X10-8 mm Hg at 25 deg C (est)
-24 º (c=8, 6N HCl)
Safety Information
NONH for all modes of transport
3
33-36/37/38
22-24/25-36-26
PD0455000
Xi
Stable. Incompatible with strong oxidizing agents.
D-Methionine Use and Manufacturing
N-d-AAase activity was measured using N-acetyl-d-methionine as a substrate. Concentration of reaction product was measured by applying a d-amino acid oxidase coupling with horse radish peroxidase. The detailed condition was as previously described [17]. Basically, N-d-AAase and N-acetyl-d-methionine were incubated at 4 ◦C. Then the mixture of d-amino acid oxidase and colorimetric solution containing peroxidase (10 U/ml), 4-aminoantipyrine (0.04 g/ml) and 0.8 l phenol was added. The OD at wavelength 520 nm was measured. One unit was defined as generation of 1 mol d-methionine in 1 min. Protein concentration was determined by the Bradford method and bovine serum albumin as the standard [32]. Kinetic parameters kcat and Km values were determined by fitting the initial rates as a function of substrate concentration to the Michaelis–Menten equation.
For biochemical research and nutritional supplements
D-Methionine: ACTIVE
EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Human Drugs -> EU pediatric investigation plans|Cosmetics -> Antistatic; Hair conditioning; Skin conditioning
Computed Properties
Molecular Weight:149.21
XLogP3:-1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:149.05104977
Monoisotopic Mass:149.05104977
Topological Polar Surface Area:88.6
Heavy Atom Count:9
Complexity:97
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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