4-Fluoroisoquinoline

To a solution of n-butyl lithium (133 mL, 332.5 mmol, 2.5 M in THF) in 760 mL THF was added a solution of 4-bromoisoquinoline 24a (20 g, 96.6 mmol) in 144 mL THF dropwise at -65° C. and the resulting mixture was stirred at this temperature for another 30 mm after the completion of addition. To a solution of n-butyl lithium (133 mL, 332.5 mmol, 2.5 M in THF) in 760 mL THF was added a solution of 4-bromoisoquinoline 24a (20 g, 96.6 mmol) in 144 mL THF dropwise at -65° C. and the resulting mixture was stirred at this temperature for another 30 mm after the completion of addition. Production of 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride from 4-fluoroisoquinoline To a 10-L-capacity reactor equipped with a stirrer, a thermometer, a condenser, and a dropper, 4-fluoroisoquinoline (750.0 g, 5.1 mol) which has been produced according to the method disclosed in the pamphlet of1-Chloro-1-chloro-

Molecular Weight:147.15
XLogP3:2.2
Hydrogen Bond Acceptor Count:2
Exact Mass:147.048427358
Monoisotopic Mass:147.048427358
Topological Polar Surface Area:12.9
Heavy Atom Count:11
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes