 Home > Encyclopedia > 2-Amino-4-fluorophenol

2-Amino-4-fluorophenol

2-Amino-4-fluorophenol structure

CAS No:
399-97-3
Formula:
C6H6FNO
Chemical Name:
2-Amino-4-fluorophenol
Synonyms:
Phenol,2-amino-4-fluoro-;2-Amino-4-fluorophenol;5-Fluoro-2-hydroxyaniline;4-Fluoro-2-aminophenol
Categories:
Organic Chemistry > Organic Fluorine Compound

Request for Quotation

Description

White to brown solid

2-Amino-4-fluorophenol Basic Attributes

Molecular Weight：

127.12

Exact Mass：

127.12

EC Number：

1592732-453-0

DSSTox ID：

DTXSID80192952

HScode：

2922299090

Characteristics

PSA：

46.2

XLogP3：

1.3

Appearance：

WHITE TO BROWN SOLID, POWDER, CRYSTALS,CRYSTALLINE POWDER AND/OR CHUNKS

Density：

1.3±0.1 g/cm3

Melting Point：

145-146 °C

Boiling Point：

252.9°C at 760 mmHg

Flash Point：

106.7±23.2 °C

Refractive Index：

1.602

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-36/37/38-22

safety instructions：

26-36/37/39

Marks：

Xi,Xn

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (97.83%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Amino-4-fluorophenol Use and Manufacturing

Tin(II) chloride (12.1 g, 63.6 mmol) was added to a solution of 4-fluoro-2- nitrophenol (2.00 g, 12.7 mmol) in EtOH (45 mL), and the reaction mixture was heated to 70 a) [0140] 300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol and 120 mg of 10percent palladium/carbon was added, followed by stirring under a hydrogen atmosphere at room temperature for 1 hour. The insoluble material was filtered and subsequently the filtrate was distilled off under reduced pressure to afford 211 mg of the title compound. [0141] a) 2-Amino-4-fluorophenol [0152] 300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol and 120 mg of 10percent palladium/ carbon was added, followed by stirring under a hydrogen atmosphere at room temperature for 1 hour. The insoluble material was filtered and subsequently the filtrate was distilled off under reduced pressure to afford 211 mg of the title compound. 300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol and 120 mg of 10percent palladium/carbon was added, followed by stirring under a hydrogen atmosphere at room temperature for 1 hour. The insoluble material was filtered and subsequently the filtrate was distilled off under reduced pressure to afford 211 mg of the title compound. [0170] 300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol and 120 mg of 10percent palladium/ carbon was added, followed by stirring under a hydrogen atmosphere at room temperature for 1 hour. The insoluble material was filtered and subsequently the filtrate was distilled off under reduced pressure to afford 211 mg of the title compound. [0171] In a 500-ml flask, place 39.3 g (0.25 m) of 4-fluoro-2-nitrophenol (2a) and 120 ml of isopropyl alcohol and warm to 40° C.

Computed Properties

Molecular Weight:127.12
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:127.043341977
Monoisotopic Mass:127.043341977
Topological Polar Surface Area:46.2
Heavy Atom Count:9
Complexity:99.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Amino-4-fluorophenol

QUANHUI BIO Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of API & INTERMEDIATE

2-AMINO-4-FLUOROPHENOL

Unit Price: $100 /KG EXW

CAS No.: 399-97-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry