N,N'-(OXYDI-4,1-PHENYLENE)BISACETAMIDE

To a stirred acetone (50 ml) solution of 4, 4?-diaminodiphenyl ether (2) (5.0 g, 19.6 mmol) at 0 C, acetic anhydride (10.0 ml, 105.8 mmol) was added dropwise and reaction had been carried out for 3 h. The reaction was monitored by TLC. After stopping the reaction, triethylamine (25 ml, 179.4 mmol) was added dropwise, neutralizing the solution, to give a white solid, filtrated, washed with acetone, and dried to obtain the compound 3.To a stirred acetone (50 ml) solution of 4, 4?-diaminodiphenyl ether (2) (5.0 g, 19.6 mmol) at 0 C, acetic anhydride (10.0 ml, 105.8 mmol) was added dropwise and reaction had been carried out for 3 h. The reaction was monitored by TLC. After stopping the reaction, triethylamine (25 ml, 179.4 mmol) was added dropwise, neutralizing the solution, to give a white solid, filtrated, washed with acetone, and dried to obtain the compound 3. And then, the above obtained compound 3 (6.2 g, 16.6 mmol) was dissolved with acetic acid (50 ml) and stirred at 0 C for 10 minutes. Fuming nitric acid (8 ml, 171.7 mmol) was added dropwise to the above solution within 2 h. After that, the ice-bath was removed and the reaction mixture was further stirred at room temperature for 2 h. The mixture was poured into ice (100 ml), the resulting yellow solid (compound 4) was filtered, washed with water,

N,N'-(Oxydi-4,1-Phenylene)Bisacetamide is a chemical reagent used in the synthesis of photosensitive polymer compounds and optical application. It also is used in the preparation of benzimidazole derivatives displaying anti-tumor activity through apoptosis.

Molecular Weight:284.31
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:284.11609238
Monoisotopic Mass:284.11609238
Topological Polar Surface Area:67.4
Heavy Atom Count:21
Complexity:323
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes