2,3,5-Tribromothiophene

white to light yellow crystal powder

Compound 25-2 (0443) To a solution of thiophene (84 g, 1.0 mol) in chloroform (34 mL) was added dropwise bromine at rt for 3 h. When the addition was complete, the mixture was stirred at rt overnight. The mixture was heated to 50° C. for 3 h. The reaction mixture was washed with 1M NaOH (aq. 100 mL), brine (100 mL×2) respectively. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to afford light yellow oil, which was solidified in methanol (100 mL). The solid was filtered and dried in vacuo to afford 25-2 (89 g, 56percent).a, the chloroform 35L, thiophene and 16.8 kg 0.168kg copper bromide into reactor 1, stirred for 10 minutes, in a jacketed reactor was cooled to -5 water when the tank by the dropwise addition of 65.0kg of bromine was added dropwise 6 into the reactor 1. document.write("); B, the drum to the reaction vessel 1 with air or oxygen after start of the reaction, after completion of bromine was slowly added dropwise, and then slowly heated to reflux for 1 reactor, the gas is condensed by the reflux condenser 8 into the reactor 1 at reflux, the reaction after 3.5 hours, cooled to 23 -25 ; document.write("); C, the ethanol solution was added dropwise to the reactor tank 1 7 added dropwise 10L0.05mol / L sodium hydroxide, the decomposition of unreacted bromine and stirred for 30 minutes.document.write("); d, the reaction mixture was washed into the autoclave 2 was added 35L of water, stir for 30 minutes, allowed to stand, the lower organic phase into the distillation still 3 atmospheric distillation, followed by distillation gas condenser 9, distillation condenser 10 after the condensation, the first fraction prior to recycling the solvent and the solvent recovery tank 4, and then distilled under reduced pressure to 15mmHg, followed after distillation gas condenser 9, distillation condenser 10 condensed, collecting 112 ~ 116 / 15mmHg into the product fraction collected tank 5 to give colorless liquid 52.6kg2, 3, 5- three bromothiophene product

Molecular Weight:320.83
XLogP3:4.3
Hydrogen Bond Acceptor Count:1
Exact Mass:319.73286
Monoisotopic Mass:317.73491
Topological Polar Surface Area:28.2
Heavy Atom Count:8
Complexity:87.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes