Adenosine monophosphate

347.22

347.22

200-500-0

415SHH325A

DTXSID5022560

CRYSTALS FROM WATER + ACETONE|POWDER, NEEDLES FROM WATER & DIL ALC

29389090

186

-3.1

Colorless to white Crystalline Powder

2.32±0.1 g/cm3(Predicted)

196-200 °C

798.5°C at 760 mmHg

soluble in water.H2O: with addition of mild alkalisoluble

−20°C

Peritoneal-mouse LD50: 4000 mg/kg

Flammable; heat produces toxic nitrogen oxides and phosphorus oxide fumes

SPECIFIC OPTICAL ROTATION: -26 DEG @ 20 °C/D (C= 2, 10% HCL); & -47.5 DEG @ 20 °C/D (C= 2, 2% NAOH)

PK1= 3.8; PK2= 6.2

171.4 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|173.33 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|180.73 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|175.33 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|167 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|171.4 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|177 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|173.1 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|179.5 Ų [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|167.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

MOLAR ABSORBANCY= 15400 @ 259 NM (PH 7.0); READILY DEAMINATED BY NITROUS ACID TO FORM INOSINIC ACID; LESS RAPIDLY HYDROLYZED THAN 3'-ADENYLIC ACID BY SULFURIC ACID|LONG CRYSTALLINE RODS; DECOMP AT 195 °C /YEAST ADENYLIC MONOHYDRATE/|DECOMP AT 208 °C /YEAST ADENYLIC ANHYDRATE/|GIVES ONLY TRACES OF FURFURAL WHEN BOILED WITH 20% HYDROCHLORIC ACID

3

24/25

AU7480500

Warehouse ventilated, low temperature and dry

FREE ACID & ITS SALTS ARE STABLE FOR LONG PERIODS IN DRY STATE; NEUTRAL SOLN ARE ALSO STABLE

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

Not Classified| |Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 94 companies from 2 notifications to the ECHA C&L Inventory.

moderately toxic

NUCLEOTIDE; WIDELY DISTRIBUTED IN NATURE.

For nutritional supplementation, also for treating dietary shortage or imbalance

ENERGY-RICH PHOSPHATES REPRESENT "ENERGY POOL" FROM WHICH CELLS OBTAIN THEIR ENERGY REQUIREMENTS. IN PATHOLOGICAL SITUATIONS, WHERE METABOLISM IS ALTERED, SPECIFIC DETERMINATION OF NUCLEOTIDES IS OF DIAGNOSTIC VALUE & IS INCREASINGLY USED IN HEART, LIVER & KIDNEY DISEASES.

Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.

AMP ADMIN TO RATS ORALLY WAS RECOVERED INTACT IN BLOOD. IT APPEARED RAPIDLY IN BLOOD (IN 15-30 MIN) & WAS ALSO RAPIDLY DISTRIBUTED, SINCE PLASMA CONCN WAS DECR BY FACTOR OF 5 IN 2 HR.

Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvation-induced immunosuppression, the enhancement of T-cell maturation and function, the enhancement of natural killer cell activity, the improvement of delayed cutaneous hypersensitivity, helping resistance to such infectious agents as Staphylococcus aureus and Candida albicans, and finally the modulation of T-cell responses toward type 1 CD4 helper lymphocytes or Th1 cells. Studies have shown that mice fed a nucleotide-free diet have both impaired humoral and cellular immune responses. The addition of dietary nucleotides normalizes both types of responses. RNA, a delivery form of nucleotides, and ribonucleotides were used in these studies. The mechanism of the immune-enhancing activity of nucleic acids/nucleotides is not clear.

LOCAL ERYTHEMIA, SLIGHT FLUSHING, DIZZINESS, DIURESIS, & PALPITATION... ESPECIALLY WITH LARGE DOSES OF AQ SOLN. IN TREATMENT OF BURSITIS OR CHRONIC CALCIFIC TENDINITIS /DRUG OFTEN PRODUCES/ EXACERBATION OF SYMPTOMS AFTER 5TH TO 10TH DAY /ADVERSE EFFECT, IM (AS SODIUM SALT)/|DIARRHEA, DIZZINESS, & HEADACHE /SUBLINGUAL ADMIN/. ANAPHYLACTIC SHOCK... FOLLOWING USE OF GELATIN SOLN /IM ADMIN AS SODIUM SALT/. DYSPNEA & TIGHTNESS OF CHEST /ADVERSE EFFECT/

2' Adenosine Monophosphate

5'-Adenylic acid: ACTIVE|MONOPHOSPHORIC ESTER OF ADENOSINE, IE, NUCLEOTIDE CONTAINING ADENINE, D-RIBOSE & PHOSPHORIC ACID. ADENYLIC ACID IS CONSTITUENT OF MANY IMPORTANT COENZYMES.

ENZYMATIC DETERMINATION WITH MYOKINASE, MK...ESTIMATES ADP & AMP IN SINGLE ASSAY SYSTEM. THIS METHOD IS PREFERABLE TO EXISTING CHROMATOGRAPHIC METHODS, ESP WITH SERIAL MEASUREMENTS, BECAUSE OF ITS SIMPLICITY & SPEED. BLOOD & TISSUE, ENZYMATIC DETERMINATION BY SPECTROPHOTOMETRY.

Cosmetics -> Skin conditioning