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Trimagnesium dicitrate

Trimagnesium dicitrate structure

CAS No:
3344-18-1
Formula:
C6H8O7.³/2Mg
Chemical Name:
Trimagnesium dicitrate
Synonyms:
1,2,3-Propanetricarboxylic acid,2-hydroxy-,magnesium salt (2:3);Citric acid,magnesium salt (2:3);Magnesium citrate;Hexaaquomagnesium bis[(citrato)aquomagnesate];Trimagnesium dicitrate;Citramag;12405-09-3
Categories:
Organic Chemistry > Organometalate

Description

White or slightly yellow granules powder

Trimagnesium dicitrate is a magnesium salt composed of magnesium and citrate ions in a 3:2 ratio. It has a role as a laxative. It contains a citrate(3-).|Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the specifications of oral administration of a maximum concentration of 237 mg. It is also considered as an active ingredient in over-the-counter products.|Magnesium Citrate is the citrate salt of the element magnesium with cathartic activity. The cathartic action of magnesium cations appears to result, in part, from osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate intestinal secretion via prostaglandin- and cyclic GMP-dependent mechanisms while PAF produces significant stimulation of colonic secretion and gastrointestinal motility.

Trimagnesium dicitrate Basic Attributes

Molecular Weight：

451.11400

Exact Mass：

449.96200

EC Number：

222-093-9

UNII：

RHO26O1T9V

NCI Thesaurus Code：

C29241

ATC Code：

A - Alimentary tract and metabolism|B - Blood and blood forming organs

HScode：

2918150000

Characteristics

PSA：

198.26000

XLogP3：

-2.95960

Appearance：

White or slightly yellow granules powder

Melting Point：

184

Boiling Point：

309.6ºC at 760 mmHg

Flash Point：

155.2ºC

Water Solubility：

Slightly soluble in water.

Safety Information

hazard class code：

R36/37/38

safety instructions：

S26; S36

RTECS Number：

TZ8552900

Marks：

Toxicity

Toxicity Summary：

The occurrence of overdose with magnesium citrate is very unlikely but some of the signs of the presence of overdose are diarrhea or severe stomach pain.

Protein Binding：

Magnesium, once ionized, is highly bound to plasma proteins and it can represent even 90% of the magnesium found in blood plasma.

Drug Information

Drug Indication：

Magnesium citrate has been used in bowel preparations prior to a colonoscopy as a cathartic agent. It is also used in over-the-counter products to relieve occasional constipation. Magnesium citrate can be one of the forms used for the administration of dietary supplements.

Pharmacology：

The onset of action can be as early as 30 minutes after administration with a mean onset time of approximately 2 hours and a maximum action of 4 hours. The effect of magnesium citrate is highly dependent on the individual's hydration status.

MeSH：

Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)

Absorption：

Mean plasma concentration of magnesium after administration of oral doses of magnesium citrate are reported to be of around 0.7 mmol/L and the concentration in saliva rested in 0.28 mmol/L. In reports, it has also been proven that the absorption and bioavailability of magnesium are greater when administered in the form of magnesium citrate when compared with other forms such as magnesium ocude.|After oral administration of magnesium citrate, there is a 40% increase in urine excretion of magnesium. Magnesium citrate is also widely eliminated via the feces because, when present in the bowel, it relaxes the bowel and pulls water into the intestine which increases bowel movement and a significant portion of this agent gets excreted by this via.

Biological Half-Life：

The study of the half-life of magnesium citrate is very difficult due to the half-life of the available isotopes for magnesium.

Mechanism of Action：

It mainly works through its property of high osmolality which will draw large amounts of fluid into the colonic lumen. There is also a possible stimulation of fluid excretion by cholecystokinin release and activation of muscle peristalsis.

MeSH Entry Terms：

magnesium citrate

Trimagnesium dicitrate Use and Manufacturing

Uses

Magnesium citrate (3:2) (3 magnesium atoms per 2 citrate molecules), also called trimagnesium dicitrate, trimagnesium citrate, or the ambiguous name magnesium citrate (which can also mean magnesium citrate (1:1)), is a salt of magnesium and citric acid. It is not very soluble in water and has a bitter taste. It contains 16.2% magnesium by weight. Compared to magnesium citrate (1:1), it is much less water-soluble, more alkaline, and contains 42.6% more magnesium by weight.

Manufacturing Info：

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (1:?): ACTIVE

Use Classification：

Food Additives -> FOOD_ADDITIVE; -> JECFA Functional Classes

Food Additive Classes：

Food Additives -> FOOD_ADDITIVE;

Computed Properties

Molecular Weight:451.12
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:4
Exact Mass:449.9621801
Monoisotopic Mass:449.9621801
Topological Polar Surface Area:281
Heavy Atom Count:29
Complexity:211
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes

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