Diheptyl phthalate

362.5

362.50

2336623

222-885-4

IE05VO8P8P

0832

DTXSID0028662|DTXSID8040779

Colorless liquid

29173490

52.6

8

Diheptyl phthalate appears as odorless white liquid. May float or sink in water. (USCG, 1999)

0.99 g/cm³

<40 °C

360 °C @ Press: 760 Torr

>230 °F

1.492

Sparingly soluble in water.In water, 1.83X10-3 mg/L at 25 deg C (est)

Vapour pressure, kPa at 20°C: 0.0002

Practically odorless

Henry's Law constant = 3.54X10-6 atm-cu m/mol at 25 °C (est)

0.14% (by wt) of water in the phthalate|Most phthalate esters have a relatively high calculated log octanol/water partition coefficient > 2.12 indicating that they are lipophilic. /Phthalate esters/|... Resistance to migration from polymers, low temperature flexibility ... compatibility with polar polymers and additives over a wide range of compositions. /Phthalate esters/|Phthalate esters would be expected to have UV maxima in the 230 nm and 270 nm regions. /Phthalate esters/|Hydroxyl radical reaction rate constant = 1.78X10-11 cu cm/molec-sec at 25 °C (est)

No rapid reaction with air. No rapid reaction with water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

DIHEPTYL PHTHALATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

-16,850 Btu/lb= -9,370 cal/g= -392X10+5 J/kg (est)

Ⅲ

2811

3

36/37/38-63

26-36/37

TI1090000

Xn,Xi

P261-P281-P305 + P351 + P338

H315-H319-H335-H361

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Nat'l Research Council Canada; Phthalate Esters in the Aquatic Environment (1980) NRCC No. 17583|USEPA; Ambient Water Quality Criteria Doc: Phthalate Esters (1980) EPA 440/5-80-067|USEPA/ECAO; Atlas Document for: Phthalate Esters (1980)|Woodward KN et al; HM Stationery Office Publications Centre p183 1986. Review of the toxicity of the esters of o-phthalic acid (phthalate esters).

Combustible.

|Warning|H315 (90.48%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501

Goggles or face shield; rubber gloves (USCG, 1999)

Foam, dry chemical, carbon dioxide.

Removal of phthalate esters (PAEs) by alpha-cyclodextrin (CD)-linked chitosan bead in aqueous solution was studied. Results of kinetic experiments indicated that diheptyl phthalate (DHpP) was adsorbed most efficiently (3.21 mg/g) ... It was concluded that the application of low cost alpha-CD-linked chitosan bead could have the potential to effectively remove PAEs from different aquatic environments.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety spectacles.

SEDIMENT: Sediment samples taken Sept 1995 from the mouth of 3 rivers (The Hokura flows 54.7 km and includes industrial and agricultural areas; The Shinano flows 366.8 km and includes urban and agricultural areas; The Tainai includes industrial and agricultural areas, draining 151 sq km) were negative for diheptyl phthalate(1). It was detected, not quantified in 1 port in Niigata, Japan(1).

INDOOR AIR: Diheptyl phthalate associated with small particulates was detected inside a telephone office building in Wichita, KS, at a concentration of 1 ng/cu m(1).

The ability of phthalic acid, phthalic acid anhydride, and various phthalate esters to enhance the mutagenicity of many amino acid pyrolysates was observed with the Ames test (Salmonella typhimurium TA98), but not the SOS Chromotest. Phthalate enhancement of the mutagenicity of 4-nitroquinoline-1-oxide, 2-nitrofluorene, and benzo[a]pyrene was not observed with either test. The mutagenicity-enhancing ability may be related to the induction of enzymes such as P450IIB, that metabolize amino acid pyrolysates. By quantitative structure activity relationship (QSAR) analysis, a good correlation was observed between the mutagenicity-enhancing activity of phthalates and their octanol-water partition coefficients.

/AQUATIC SPECIES/ The extensive database of acute and chronic aquatic toxicity data for 18 phthalate esters was reviewed and summarized for freshwater and saltwater aquatic microorganisms, algae, invertebrates, and fish. Phthalate esters have been tested with six species of microorganisms, including bacteria and protozoans. Fifteen algal species have been tested, including green and bluegreen algae in both freshwater and saltwater. Nineteen freshwater and saltwater invertebrate species inhabiting surface waters and sediments and 21 freshwater and saltwater fish inhabiting cold and warm water bodies have been tested. The results of most studies indicate that acute and chronic toxicity to microorganisms, algae, aquatic invertebrates, and fish are limited to the lower molecular weight phthalate esters (i.e., dimethyl-, diethyl-, diallyl-, dipropyl-, dibutyl-, diisobutyl-, and butylbenzylphthalate). In contrast, higher molecular weight phthalate esters are not acutely or chronically toxic to aquatic organisms. Although conflicting data on chronic effects for high molecular weight phthalate esters have been reported for daphnids, these inconsistencies are attributed to physical effects imposed on daphnids when exposed to test concentrations in excess of true water solubilities. Altogether, nearly 400 test results covering more than 60 species of microorganisms, algae, invertebrates, and fish are reported for both freshwater and saltwater aquatic species. While most investigators used several common species and standard protocols to assay conventional endpoints, many nontraditional species and toxicological endpoints were also used. This has created a toxicological database of both sufficient depth to compare many similar tests and sufficient breadth to encompass virtually al important types of aquatic habitats and classes of aquatic species.

Diheptyl phthalate's production and use as a plasticizer for vinyl resins(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 5.7X10+4(SRC), determined from a structure estimation method(2), indicates that diheptyl phthalate is expected to be immobile in soil(SRC). In sterile microcosms containing lake water and sediment, approximately 80% of a mixture of di(heptyl,nonyl,undecyl) phthalate partitioned to sediment(3). Volatilization of diheptyl phthalate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Diheptyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.1X10-6 mm Hg(SRC), determined from a fragment constant method(5). A 36% theoretical BOD in two weeks using an activated sludge inoculum in the Japanese MITI test suggests that biodegradation is expected to be an important process in soil(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 5.7X10+4(SRC), determined from a structure estimation method(2), indicates that diheptyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 20 and 150 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. According to a classification scheme(5), BCFs of 0.9 to 16.7(6), suggest the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important process(SRC) based on estimated hydrolysis half-lives of 3.4 years and 130 days at pH 7 and 8, respectively(7). The mixture di(heptyl,nonyl,undecyl)phthalate had a half-life of 6 to 8 days in river die-away tests(8), suggesting that biodegradation is expected to be an important process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diheptyl phthalate, which has an estimated vapor pressure of 2.1X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase diheptyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 hours(SRC), calculated from its rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase diheptyl phthalate may be removed from the air by wet or dry deposition(SRC). Diheptyl phthalate does contain chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of diheptyl phthalate with photochemically-produced hydroxyl radicals has been estimated as 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 22 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 6.4X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 3.4 years and 130 days at pH values of 7 and 8, respectively(2). Diheptyl phthalate does contain chromophores that absorb at wavelengths >290 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

BCFs of 0.9 to 2.2 and 6.2 to 16.7 were measured for diheptyl phthalate in carp at chemical concentrations of 1 and 0.1 mg/L, respectively(1). According to a classification scheme(2), these measured BCFs suggest that bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diheptyl phthalate can be estimated to be 5.7X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that diheptyl phthalate is expected to be immobile in soil. In sterile microcosms containing lake water and sediment, approximately 80% of di(heptyl,nonyl,undecyl) phthalate partitioned to sediment(3).

The Henry's Law constant for diheptyl phthalate is estimated as 3.5X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that diheptyl phthalate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 20 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 150 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. Diheptyl phthalate's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Diheptyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.1X10-6 mm Hg(SRC), determined from a fragment constant method(3).

RAIN/SNOW: Snow surface analysis were done on seven sites in the Antarctic in 1993/1994 season, results for diheptyl phthalate are; Wood Bay at sea level (6 ng/L), Mt Melbourne at 200 meters above sea level (below detection limit), Vegetation Island at 220 meters above sea level (14 ng/L), Mt Melbourne at 600 meters above sea level (10 ng/L), McCarthy Ridge at 790 meters above sea level (3 ng/L), Mt Melbourne at 1130 meters above sea level (5 ng/L) and Hercules Neve at 2960 meters above sea level (below detection limit)(1). Subsurface snow samples at McCarthy Ridge analyzed for diheptyl phthalate found concns of 23 ng/L at 1 meter deep, 6 ng/L at 2 meters deep and 17 ng/L at 3 meters deep(1). Subsurface snow samples taken at Hercules Neve gave diheptyl phthalate results of 57 ng/L at 1 meter deep, 28 ng/L at 2 meters deep and 7 ng/L at 3 meters deep(1).

Occupational exposure to diheptyl phthalate may occur through inhalation of aerosols and dermal contact with this compound at workplaces where diheptyl phthalate is used as a plasticizer or where vinyl resins are produced. Use data indicate that the general population may be exposed via dermal contact with consumer products containing this compound. (SRC)

Diheptyl phthalate was detected in 2 of 46 human adipose tissue samples analyzed for the National Human Adipose Tissue Survey, FY 1982(1).

Inhalation of vapors from very hot material may cause headache, drowsiness, and convulsions. Contact with eyes may cause irritation. (USCG, 1999)

INHALATION: move to fresh air. EYES: flush with water. SKIN: wipe off; flush with water; wash with soap and water. (USCG, 1999)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

diheptyl phthalate

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

1,2-Benzenedicarboxylic acid, 1,2-diheptyl ester: ACTIVE|It imparts very good cold resistance to manufactured articles and exerts a lubricating action during fabrication, making it possible to obtain finished articles with smooth shining surfaces.

DIHEPTYL PHTHALATE WAS COLLECTED FROM AIR. FILTERS & PLUGS WERE EXTRACTED IN A SOXHLET EXTRACTOR WITH PETROLEUM ETHER IN HEXANE. ANALYSIS WAS BY GAS CHROMATOGRAPHY WITH AN ELECTRON CAPTURE DETECTOR. MINIMUM DETECTABLE CONCN WAS 0.001 UG/CU M. AVG RECOVERY WAS 93.3%.|IN AN ATTEMPT TO DEVELOP A METHOD FOR THE DETERMINATION OF PHTHALATE ESTERS IN WATER BY ADSORPTION CHROMATOGRAPHY, THE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC BEHAVIOR OF DIHEPTYL PHTHALATE IN WATER USING AN OCTADECYLTRICHLOROSILANE BONDED STATIONARY PHASE WAS EXAMINED. PHTHALATE ESTERS IN WATER WERE COMPLETELY ADSORBED ON OCTADECYLTRICHLOROSILANE BONDED BEADS AND THEIR ELUTION ORDER IN 100% WATER TO 100% METHANOL GRADIENT SYSTEM WAS DIRECTLY RELATED TO THE NUMBER OF ALKYL CARBON ATOMS IN THE ESTER GROUPS OF PHTHALATES. STUDY INDICATED THAT THE SEPARATION MECHANISM MAY BE DUE TO THE INTERACTION OF AFFINITY BETWEEN OCTADECYL GROUPS OF THE BONDED STATIONARY PHASE AND THE LENGTH OF THE ALKYL CHAIN IN THE ESTER GROUP OF EACH PHTHALATE WITH SOLUBILITIES OF EACH PHTHALATE ESTER FOR THE MOBILE PHASE.

THE KOVATS RETENTION INDEX DIHEPTYL PHTHALATE WAS DETERMINED BY GLASS CAPILLARY COLUMN GAS CHROMATOGRAPHY FOR IDENTIFICATION OF THE ESTERS IN BIOLOGICAL FLUIDS. COLUMN PARAMETERS WERE: 0.5% OV-101 COATINGS, 230 °C, HELIUM OR NITROGEN AS CARRIER GAS; 0.5% SE-30 COATING, 250 °C; A FLAME IONIZATION DETECTOR WAS USED WITH BOTH COLUMNS.