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Sarcosine

Sarcosine structure

Sarcosine 

structure
  • CAS No:

    107-97-1

  • Formula:

    C3H7NO2

  • Chemical Name:

    Sarcosine

  • Synonyms:

    Glycine,N-methyl-;Sarcosine;N-Methylglycine;Acetic acid,(methylamino)-;(Methylamino)acetic acid;N-Methylaminoacetic acid;(Methylamino)ethanoic acid;Sarcosinic acid;Sarcosin;Methylglycine;2-(Methylamino)acetic acid;2-(Methylazaniumyl)acetate;783292-49-9

  • Categories:

    Biochemical Engineering  >  Amino Acids and Proteins

Description

White crystalline powderChEBI: A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine.Sarcosine is the N-methyl derivative of glycine. It can be metabolized to the glycine through sarcosine dehydrogenase. It can be naturally found in many body tissues including muscles. In the laboratory, sarcosine could be synthesized through the reaction between chloroacetic acid and methylamine. Sarcosine is a potential interesting direction for


Deliquescent crystals or powder. Has a sweetish taste. (NTP, 1992)|Liquid|Solid


Deliquescent crystals or powder. Has a sweetish taste. (NTP, 1992)|Sarcosine is a N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine. It has a role as a glycine transporter 1 inhibitor, a glycine receptor agonist, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a N-alkylglycine, a N-methyl-amino acid and a member of N-methylglycines. It is a conjugate base of a sarcosinium. It is a conjugate acid of a sarcosinate. It is a tautomer of a sarcosine zwitterion.|Sarcosine has been investigated for the treatment of Schizophrenia.|An amino acid intermediate in the metabolism of choline.

Sarcosine Basic Attributes

89.09

89.09

1699442

203-538-6

Z711V88R5F

118114

DTXSID1047025

29224995

Characteristics

49.3

-2.8

Colorless or white to yellow Crystals or Powder

1.1948 (rough estimate)

212.5 °C (decomp)

165.17°C (rough estimate)

>100℃

1.4368 (estimate)

H2O: 1480 g/L (20 ºC)

Store at RT.

0.184mmHg at 25°C

Deliquescent. Water soluble.

Acids, Carboxylic

SARCOSINE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This chemical is incompatible with acids. (NTP, 1992).

Safety Information

NONH for all modes of transport

1

36/37/38

24/25-36-26

VQ2897000

Xi

Stable at room temperature in closed containers under normal storage and handling conditions.

P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P308+P313, P312, P322, P330, P363, P405, P501

H302

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

|Danger|H315 (62.9%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, and P362|Aggregated GHS information provided by 71 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Magnesium Sarcosylate

Sarcosine Use and Manufacturing

Methods of Manufacturing

It is made from the bark (phloem) of Quillia saponaria, extracted with hot water or aqueous ethanol, and then added with ether or acetone to precipitate it, and then recrystallized and refined. The main component is saponin (saponin saponin, etc.). The tree is mainly wild in Chile and Bolivia in South America, and is also produced in China.

Uses

Sarcosine can improve people's intelligence, especially for exams such as the students need to temporarily increase the effectiveness of intelligence is more obvious. sarcosine can increase muscle strength and anaerobic explosiveness.To prevent damage caused by the brain injury. Sarcosine can effectively improve athletic performance,power, and shorten muscle recovery time.


Cleaning and furnishing care products

Production

25,000 - 100,000 lb

Soap, cleaning compound, and toilet preparation manufacturing|Glycine, N-methyl-, N-coco acyl derivs.: ACTIVE|Glycine, N-methyl-: ACTIVE

EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Cleansing; Skin conditioning; Surfactant

Computed Properties

Molecular Weight:89.09
XLogP3:-2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:89.047678466
Monoisotopic Mass:89.047678466
Topological Polar Surface Area:49.3
Heavy Atom Count:6
Complexity:52.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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