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Centrophenoxine

Centrophenoxine structure

CAS No:
3685-84-5
Formula:
C12H16ClNO3.ClH
Chemical Name:
Centrophenoxine
Synonyms:
Acetic acid,2-(4-chlorophenoxy)-,2-(dimethylamino)ethyl ester,hydrochloride (1:1);Acetic acid,(p-chlorophenoxy)-,2-(dimethylamino)ethyl ester hydrochloride;Acetic acid,(4-chlorophenoxy)-,2-(dimethylamino)ethyl ester,hydrochloride;Dimethylaminoethyl 4-chlorophenoxyacetate hydrochloride;Acephen;Centrophenoxine hydrochloride;Lucidryl hydrochloride;Meclofenoxate hydrochloride;Centrophenoxine;2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride;Meclophenoxate hydrochloride;Acefen;Lucidril;Cerutil;Dimethylaminoethyl p-chlorophenoxyacetate hydrochloride;Helfergin;Marucotol;Methocynal;Cellative;Proserout;Brenal;(4-Chlorophenoxy)-2-acetoxyethyldimethylammonium hydrochloride;2-(Dimethylamino)ethyl 2-(4-chlorophenoxy)acetate hydrochloride;1334-20-9
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.IC50 value: Target: nootropicMeclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine,

An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.

Centrophenoxine Basic Attributes

Molecular Weight：

294.17

Exact Mass：

293.058563

EC Number：

222-975-3

UNII：

5BK3070BDY

NSC Number：

758420|113619|4268

DSSTox ID：

DTXSID8045141

HScode：

2922509090

Characteristics

PSA：

38.77000

XLogP3：

2.62560

Appearance：

white crystal powder

Density：

1.3255 (rough estimate)

Melting Point：

135-139 °C

Boiling Point：

345.9ºC at 760mmHg

Storage Conditions：

−20°C

Toxicity：

Oral-rat LD50:865mg/kg;Oral-Mouse LD50: 1750 mg/kg

Flammability characteristics：

Flammable; decomposes by heating to release extremely toxic nitrogen oxides, chlorides and hydrogen chloride fumes

Safety Information

hazard class code：

22-36/37/38

safety instructions：

26-36

RTECS Number：

AG0440000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)|Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)

MeSH Entry Terms：

Atsefen

Centrophenoxine Use and Manufacturing

Plant growth regulator.

Computed Properties

Molecular Weight:294.17
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:293.0585488
Monoisotopic Mass:293.0585488
Topological Polar Surface Area:38.8
Heavy Atom Count:18
Complexity:228
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Promotes the redox metabolism of brain cells, increases the utilization of carbohydrates, and has an excitatory effect on patients with central nervous system depression

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Meclofenoxate Hydrochloride for Injection
Ingredients	The active ingredient of this product is meclofenoxate hydrochloride, and the auxiliary material is mannitol.
Indication	Not yet clear.
Specifications	0.1 g
Manufacturer	Hubei Wushi Pharmaceutical Co., Ltd.

Meclofenoxate Hydrochloride for Injection
Ingredients	The active ingredient of this product is meclofenoxate hydrochloride, and the auxiliary material is mannitol.
Indication	Not yet clear.
Specifications	0.2g
Manufacturer	Hubei Wushi Pharmaceutical Co., Ltd.

Meclofenoxate hydrochloride
Specifications	API (for injection)
Manufacturer	Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

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Registered Holders

Reyoung Pharmaceutical Co., Ltd.

China
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active
Jiangsu Hengfeng Pharmaceutical Co., Ltd.

China
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