3-Chlorophenol

128.56

128.56

203-582-6

Z2Z7M2FTAD

0150

59700

2020

DTXSID4024800|DTXSID3094129

Needles|White crystals

29081000

20.23000

2.40

M-chlorophenol appears as white crystals with an odor of phenol. Sinks in and slowly dissolves in water. (NTP, 1992)

1.268 g/cm³ @ Temp: 25 °C

32.6 °C

214 °C @ Press: 760 Torr

>230 °F

n 20/D 1.563(lit.)

soluble in ethanol and ether.

Store in tightly closed containers in a cool, well ventilated area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to precess containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and

1 hPa (44 °C)

LD50 orally in rats: 0.57 g/kg (Deichmann)

Odor similar to phenol

Strong medicinal taste

9.12None

3.45e-07 atm-m3/mole|Henry's Law constant = 3.45X10-7 atm cu-m/mole at 25 °C

9.12|pKa = 9.12 at 25 °C

Dipole moment in benzene: 2.10 D|Medicinal, empyrumatic odor /Chlorophenols/|Taste threshold: Detection in water 1.00 ppm /Chlorophenol/|Heat of fusion = 105.789 kJ/kg at 33 °C|Hydroxyl radical reaction rate constant = 2.36X10-11 cu-cm/molec-sec at 25 °C (est)

Discolors on exposure to air. Water soluble

Phenols and Cresols

M-CHLOROPHENOL is incompatible with acid chlorides, acid anhydrides and oxidizing agents (NTP, 1992).

2760.0 kJ/mole at 77 °F solid /25 °C/

45.86 kJ/mole at 214 °C

Critical temperature = 53.20 bar; Critical pressure = 729.00 K

III

6.1

UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.UN 2020 6.1/PG 3

2

R20/21/22;R51/53

28-61-28A

SK2450000

Xn,N

Separated from strong oxidants and food and feedstuffs. Well closed.

Stable. Combustible. Incompatible with acid chlorides, oxidizing agents, acid anhydrides. Discolours in air.

P273-P280

H302-H312-H332-H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Chemical Treatability of m-Chlorophenol; Concentration Process: Biological Treatment; Chemical Classification: Phenols; Scale of Study: Laboratory Scale Type of Wastewater Used: Pure Compound (one solute in a solvent) Results of Study: 100% reduction in 28 hours; (Biodegradation by mutant Pseudomonas species).|Chemical Treatability of m-Chlorophenol with 13% NaCl Concentration Process: Resin Absorption; Chemical Classification: Phenols; Scale of Study: Unknown; Type of Wastewater Used: Industrial Wastewater Results of Study: At zero leakage sorption capacity was 0.07 lb/lb; (15 minute contact time Amberlite XAD-4 used).|A) Dissolve in such combustible solvent as alcohols, benzene etc. Spray the solvent into the furnace with afterburner and scrubber. B) Pour into sodium bicarbonate or a mixture of sand-soda ash (9:1). After mixing, transfer into a paper carton filled with packing paper. Burn more efficiently in the furnace with an afterburner and scrubber. Recommendable method: Incineration. Not recommendable method: Discharge to sewer.

USEPA; Ambient Water Quality Criteria Doc: Chlorinated Phenols (1980) EPA 440/5-80-032.|Nat'l Research Council Canada; Chlorinated Phenols (1982) NRCC No 18578|Environmental Protection Service; Chlorophenols and Their Impurities in the Canandian Environment Report EPS 3-EC-81-2 (1981).|U.S. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Chlorophenols PB/99/166639 (July 1999). Available from the Database Query page at: http://www.atsdr.cdc.gov/toxpro2.html# as of October 28, 2008

This chemical is probably combustible. (NTP, 1992)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Warning|H302 (98.28%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P391, and P501|Aggregated GHS information provided by 58 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P301+P312, P309+P311, P330, P391, P405, and P501|P260, P264, P270, P280, P301+P312, P305+P351+P338, P309+P311, P330, P337+P313, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Contact lenses should not be worn when working with this chemical. Wear splash-proof chemical goggles and face shield when working with liquid, unless full facepiece respiratory protection is worn. Wear dust-proof goggles when working with powders or dust, unless full facepiece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash. /Monochlorophenols/|ENGINEERING CONTROLS Use only in a chemical fume hood. Safety shower and eye bath.

Use dry chemical, carbon dioxide, or foam extinguishers. Vapors are heavier than air and well collect in low areas. ...Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. ...From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. /Monochlorophenols/

Phenolic cmpd in wastewater are oxidized with hydrogen peroxide catalyzed by iron(3+)-iron(2+). When the wt ratio of phenol:hydrogen peroxide is 1:3 and iron 5-100 ppm, more than 95% of the phenols are removed in 30 min from a 500 ppm phenol soln at pH 5-6 and 25-50 °C. /Phenolic cmpd/|Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. /Monochlorophenols/

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Immediately wash contaminated areas of skin with concentrated soap solution. Contaminated gloves, clothing, shoes should be removed without delay and disposed by incineration.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Chlorophenols, liquid; Chlorophenols, solid/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Chlorophenols, liquid; Chlorophenols, solid/|For more DOT Emergency Guidelines (Complete) data for 3-CHLOROPHENOL (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from strong oxidants and food and feedstuffs. Well closed.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes, skin and respiratory tract.

NO open flames.

STRICT HYGIENE!

Use local exhaust.

Protective gloves. Protective clothing.

Wear safety goggles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorophenols are produced as an intermediate or final product by process units covered under this subpart. /Chlorophenols/

The major hazards encountered in the use and handling of 3-chlorophenol stem from its toxicologic properties. Toxic by all routes (ie, ingestion, inhalation, dermal absorption), exposure to this white crystalline substance may occur from its use as a chemical intermediate. Effects from exposure can include burns to the skin and eyes, weakness, headache, dizziness, shock, and death from cardiac or pulmonary failure. Contact with 3-chlorophenol should be protected against by wearing a self-contained breathing apparatus, and chemical protective clothing specifically recommended by the shipper or producer. However, if contact does occur, immediately flush affected skin or eyes with running water for at least 15 minutes, and remove and isolate contaminated clothing. While 3-chlorophenol does not ignite easily, it can burn, producing irritating and poisonous gases. For small fires involving 3-chlorophenol, extinguish with dry chemical, CO2, Halon, water spray, or standard foam. Runoff from fire control water may give off poisonous gases, and should be controlled by diking, as necessary. 3-Chlorophenol may be shipped via air, rail, road, or water in containers bearing the label, "Keep away from food." Small spills of 3-chlorophenol may be taken up with sand or other noncombustible absorbent and placed into containers for later disposal. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance.

3-Chlorophenol has been detected in the effluent of a pulp mill in Canada at concentrations of 90, 91 and 93 ug/L(1). In the analysis of chlorinated sewage treatment plant effluents, 3-chlorophenol was found at a concentration of 0.5 ug/L(2).

SEDIMENT: 3-Chlorophenol was identified, not quantified, in soil and sediment samples obtained from the Love Canal, New York(1).|SOIL: 3-Chlorophenol was detected in the soils of beech and douglas fir forests after samples were spiked with Na(37)Cl. In beech forest soils 3-chlorophenol was detected in leaf litter (<0.3 ug/kg dw), 0-5 cm deep humus (0.07 ug/kg dw), 5-10 cm deep black soil (0.04 ug/kg dw), and 10-15 cm deep black soil (<0.01 ug/kg dw). In Douglas fir forest soils, 3-chlorophenol was detected in 0-5 cm deep humus (<0.04 ug/kg dw), 5-10 cm black soil (<0.04 ug/kg dw), 10-15 cm deep gray soil (<0.02 ug/kg dw), and 15-20 cm yellow soil(<0.02 ug/kg dw)(1).|SOIL: A study was conducted of soil and water contamination in the vicinity of 2 sawmills that used chlorophenol containing preservatives used against blue-staining fungi. The soil around the treatment basins contained up to 70 mg chlorophenols/kg and that in the storage area for treated lumber up to 6 mg/kg. Contamination extended to a depth of at least 2 m near the treatment basins. /Chlorophenols/

LD50 Rat oral 0.56 mL/kg|LD50 Rat ip 355 mg/kg /From table/

/AQUATIC SPECIES/ EC50 Chlorella pyrenoidosa (algae) exposed to concn at 500,000 ug/l, /time not specified, resulted in/ complete destruction of chlorophyll. /Monochlorophenols/

3-CHlorophenol's presence in soil may be due to natural de novo synthesis or chloroperoxidase (CPO)-catalyzed chlorination of aromatic structures(1).

Chlorination of polluted & natural water can produce ... chlorophenols. /Chlorophenols/|3-Chlorophenol's production and use in organic synthesis(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an experimental Koc value of 350(2) indicates that 3-chlorophenol is expected to have moderate mobility in soil(SRC). The pKa of 3-chlorophenol is 9.12(3), indicating that this compound will partially exist in an anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 3-chlorophenol from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 3.45X10-7 atm-cu m/mole for the neutral species(5). 3-Chlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.125 mm Hg(6). 3-Chlorophenol is expected to biodegrade in both aerobic and anaerobic soils with biodegradation half-lives ranging from 15 to 160 days(6-8).|AQUATIC FATE: Based on a classification scheme(1), an experimental Koc value of 350(2) and a regression-derived equation(3), indicates that 3-chlorophenol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 3.45X10-7 atm-cu m/mole for the neutral species(4). According to a classification scheme(5), a measured BCF range of 5.1 to 16(6) suggests the potential for bioconcentration in aquatic organisms is low(SRC). 3-Chlorophenol has a reported half-life of 36 days in water(7), degraded 6% after 40 days in farm stream water, degraded 56% after 30 days in farm stream sediments(8), and degraded 31.7% after 5 days in Chinese river water(9), indicating that biodegradation of 3-chlorophenol in aquatic environments may be limited under certain conditions(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-chlorophenol, which has a vapor pressure of 0.125 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3-chlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(SRC), calculated from its rate constant of 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 3-Chlorophenol absorbs light in the deep UV, but since there is some overlap between its absorption spectrum and the tropospheric solar spectrum, degradation by natural sunlight is possible(4).

The rate constant for the vapor-phase reaction of 3-chlorophenol with photochemically-produced hydroxyl radicals has been estimated as 2.36X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.4 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 3-Chlorophenol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Aquatic photolysis of 3-chlorophenol at 296 nm results in the detachment of chloride ions with equal formation of H+. The presence of dissolved oxygen or the ionization of 3-chlorophenol due to its pKa does not affect the outcome of the reaction. The quantum yield of the photoconversion was slightly higher with the anionic form(3). 3-Chlorophenol absorbs light in the deep UV, but since there is some overlap between its absorption spectrum and the tropospheric solar spectrum, degradation by natural sunlight is possible(4). The rate constant for aqueous reaction of 3-chlorophenol with singlet oxygen (O2) in phosphate buffer at 27 °C was determined to be 1.60X10+8 mole/L-sec, which corresponds to a half-life of 6.0 hours, assuming an O2 freshwater surface concentration under noontime, midsummer sun conditions of ca. 2X10-13 mole/L(5). 3-Chlorophenol (4.46X10-5 mol) reacted with 1 ml NOx in air for 5 hr to give the 2-, 4-, and 6-nitro-3-chlorophenol adducts in 6.3%, 17%, and 11% yields, respectively(6).

15.85|Carp exposed to 40 ug/L of 3-chlorophenol for a period of 6 weeks had BCF values in the range of 5.1-10 and carp exposed to 4 ug/L of 3-chlorophenol for a period of 6 weeks had BCF values in the range of 7.0-16(1). A BCF value of 20.0 (logBCF = 1.30) for 3-chlorophenol was reported(2). According to a classification scheme(3), these BCF values suggest that the potential for bioconcentration in aquatic organisms is low(SRC).

346.74 L/kg|The Koc of 3-chlorophenol in soil was reported as 350(1). According to a classification scheme(2), this Koc value suggests that 3-chlorophenol is expected to have moderate mobility in soil(SRC). The pKa of 3-chlorophenol is 9.12(3), indicating that this compound will partially exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Chlorophenols can be irreversibly immobilized by covalent bonding to soil organic matter (SOM). Irreversible binding increased with the addition of hydrogen peroxide and under anoxic conditions(5).

The Henry's Law constant for the neutral form of 3-chlorophenol is 3.45X10-7 atm-cu m/mole(1). This Henry's Law constant indicates that 3-chlorophenol is expected to be essentially nonvolatile from water surfaces(2). 3-Chlorophenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.25X10-1 mm Hg(3).

Monochlorophenols were found in surface waters in the Netherlands at concn of 2 to 20 ug/l. /Monochlorophenols/|GROUNDWATER: 3-Chlorophenol was detected, not quantified in samples from Melbourne, Australia, collected in 1973 and 1975 in 4 bore hole samples from an aquifer polluted by a chemical company waste ponds; 75% of samples tested positive(1).|SURFACE WATER: 3-Chlorophenol was detected in freshwater streams in China at concentrations of 98.9 and 102.2 ppb(1). Monochlorophenols (including 3-chlorophenol) were found in surface waters in the Netherlands at concentrations of 2 to 20 ug/L(2). 3-Chlorophenol was detected in the Rhine River and Ijssel River, The Netherlands, with a maximum concentration of 6 ppb(3). Four out of 13 water samples from the Ijssel River contained 3-chlorophenol, at a maximum concentration of 3.4 ppb(4). 3-Chlorophenol was detected, not quantified, in water samples obtained from the Love Canal, Niagara, New York(5). The concentration of 3-chlorophenol in a section of the Isipingo River and Isipingo Estuary, Natal, Republic of South Africa, sampled on April 3 and May 8, 1991, ranged from 0.1 to 50.9 ug/L(6).|DRINKING WATER: 3-Chlorophenol was detected in the drinking water of China at concns of 106.5 and 94.8 ppb(1).|PRODUCTION MECHANISMS OF CHLOROPHENOLS BY CHLORINATION IN DISINFECTION OF WATER & DETERMINATION OF POLLUTION LEVELS OF PHENOLS AS PRECURSOR OF CHLOROPHENOLS, & CHLOROPHENOLS IN SEWAGE, STREAM WATER & TAP WATER IN THE VICINITY OF SEOUL, KOREA FROM JAN TO SEPT, 1979 WAS STUDIED. /CHLOROPHENOLS/

NIOSH has statistically estimated that 919 workers (306 of these were female) were potentially exposed to 3-chlorophenol in the US(1). Occupational exposure to 3-chlorophenol may be through inhalation of vapors and dermal contact with this compound at workplaces where 3-chlorophenol is produced or used. The general population may be exposed to 3-chlorophenol through dermal contact with and the ingestion of contaminated water sources(SRC).|The concentration of chlorophenol in the urine of 230 sawmill workers was determined between 1980 and 1981. Those workers whose main route of exposure was skin absorption had the highest mean concentrations, 7.8 umol/L with a range of 0.1 - 210.9 umol/L. Those workers whose skin and respiratory exposure were equivalent had a mean concentration of 1.4 umol/L with a range of 0.1 - 47.8 umol/L. Those whose main route of exposure was respiratory had mean concentrations of 0.9 umol/L with a range of 0.1 - 13.3 umol/L(1).

MEDICATION (VET): ANTISEPTIC

... ABSORBED FROM ... GASTROINTESTINAL TRACT & ... PARENTERAL SITES OF INJECTION. ... EXCRETED AS CONJUGATES OF SULFURIC & GLUCURONIC ACID. /CHLOROPHENOLS/

M-CHLOROPHENOL YIELDS M-CHLOROANISOLE IN GUINEA PIGS. YIELDS 4-CHLOROCATECHOL IN RABBITS. YIELDS M-CHLOROPHENYL-BETA-D-GLUCURONIDE & M-CHLOROPHENYL SULFATE IN RABBITS.|... Various chlorophenols are formed as intermediate metabolites during the microbiological degradation of the herbicides 2,4-D & 2,4,5-T and pesticides Silvex, Ronnel, lindane, and benzene hexachloride. /Chlorophenols/|Mammalian metabolism of chlorobenzene yields 3-chlorophenol as /one of/ the major products.

0.21 Days

... Chlorinated 2-phenoxyphenols, chlorinated diphenylethers, and chlorinated dibenzofurans occur as impurities in technical grade[s] of chlorophenols. /Chlorophenols/

SYMPTOMS: Symptoms of exposure to this compound include irritation, burns and corrosion of the eyes, skin, mucous membranes and upper respiratory tract. It may also cause restlessness, increase in rate of respiration, motor weakness, tremors, clonic convulsions, dyspnea, coma and death. ACUTE/CHRONIC HAZARDS: This compound is toxic by inhalation, ingestion and skin absorption. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen chloride gas. This compound may be corrosive. (NTP, 1992)|Corrosives

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Phenols are very toxic poisons AND corrosive and irritating, so that inducing vomiting may make medical problems worse. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Administer activated charcoal ... . Do not use emetics. Cover skin burns with dry, sterile dressings after decontamination ... . Maintain body temperature. /Phenols and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. DIRECT PHYSICIAN ORDER ONLY ... Treat seizures with diazepam or lorazepam. ... Use proparacaine hydrochloride to assist eye irrigation ... . /Phenols and related compounds/

/SIGNS AND SYMPTOMS/ Caution: ingestion causes incr then decr of respiration, blood pressure, urinary output; fever; increased bowel action; motor weakness; collapse with convulsions & death. Causes lung, liver, kidney damage; contact dermatitis. ... Dust causes sneezing.|/SIGNS AND SYMPTOMS/ 1. Burning pain in mouth and throat. White necrotic lesions in mouth, esophagus and stomach. Abdominal pain, vomiting, ... and bloody diarrhea. 2. Pallor, sweating, weakness, headache, dizziness, tinnitus. 3. Shock: Weak irregular pulse, hypotension, shallow respirations, cyanosis, pallor, and a profound fall in body temperature. 4. Possibly fleeting excitement and confusion, followed by unconsciousness ... 5. Stentorous breathing, mucous rales, rhonchi, frothing at nose and mouth and other signs of pulmonary edema are sometimes seen. Characteristic odor of phenol on the breath. 6. Scanty, dark-colored ... urine ... moderately severe renal insufficiency may appear. 7. Methemoglobinemia, Heinz body hemolytic anemia and hyperbilirubinemia have been reported ... 8. Death from respiratory, circulatory, or cardiac failure. 9. If spilled on skin, pain is followed promptly by numbness. The skin becomes blanched, and a dry opaque eschar forms over the burn. When the eschar sloughs off, a brown stain remains. /Phenol/

3-chlorophenol

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

Phenol, 3-chloro-: ACTIVE|Phenol, 3-chloro-, homopolymer: INACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).|The preparation of agricultural chemicals consumes 80-90% of chlorophenol production. /Chlorophenols/

AN ANALYTICAL METHOD IS DESCRIBED FOR CAPILLARY GAS CHROMATOGRAPHIC DETERMINATION, AFTER DERIVATIZATION, OF 19 INDIVIDUAL CHLOROPHENOLS (INCLUDING 2, 3, & 4-CHLOROPHENOLS). MINIMUM DETECTABLE AMT FOR MONOCHLOROPHENOLS WAS 2 UG/L. RIVER RHINE & DUTCH SURFACE WATERS WERE ANALYZED.|A method is presented for the simultaneous determination of a wide range of carboxylic acids and phenols, one being 3-chlorophenol, in water. Extractive alkylation is used with the tetrabutylammonium ion as counter ion and pentafluorobenzylbromide as alkylating agent. Extracts are analyzed by glass capillary gas chromatography and electron capture detection. Using a 1 ml water sample, the detection limit is 1-10 ug/l.|Detection of 3-chlorophenol in water samples was determined as 4-aminoantipyrine derivative by high performance liquid chromatography.|A reversed phase high pressure liquid chromatography method for resolution of phenolic compounds (pollutants), one being 3-chlorophenol, was presented. A new derivatization reaction was developed employing diazotized 4-amino-benzonitrile, which reacted also with p-substituted phenols. The products of the reaction could be extracted in n-butanol, allowing preconcentration and clean-up steps. /Phenolic cmpd/|For more Analytic Laboratory Methods (Complete) data for 3-CHLOROPHENOL (10 total), please visit the HSDB record page.

A method is described for the confirmation of 3-chlorophenol in human urine. A hydrolyzed urine sample is analyzed by gas chromatography and liquid chromatography.|Detection of trace chlorophenol residues in biological samples by quadrupole mass spectrometry with selected ion monitoring is described. Phenol concn as low as 1.0 pmol/ml urine (human) gave peaks that were readily discernible by selected-ion monitoring. /Chlorophenols/|GAS CHROMATOGRAPHIC DETERMINATION OF PHENOLIC COMPOUNDS ... IN URINE OF INDUSTRIALLY EXPOSED WORKERS WAS PERFORMED BY GC ON GLASS COLUMN CONTAINING 60/80 MESH TENAX GC USING FLAME IONIZATION DETECTORS. THE DETECTION LIMITS IN URINE RANGE FROM 0.1 MG/L URINE FOR PHENOL TO 1 MG/L FOR THE DI & TRICHLOROPHENOLS. /CHLORINATED PHENOLIC CMPD/|CHLORINATED PHENOLS IN URINE ARE ISOLATED BY SORPTION ONTO SMALL COLUMN OF MACRORETICULAR RESIN. THE PHENOLS WERE ELUTED FROM COLUMN WITH 2-PROPANOL IN HEXANE; SOLN CONCENTRATED & THE PHENOLS WERE SEPARATED & ANALYZED BY GC. /CHLORINATED PHENOLS/

Health Hazards -> Corrosives