Nobiletin
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Nobiletin
structure -
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CAS No:
478-01-3
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Formula:
C21H22O8
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Chemical Name:
Nobiletin
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Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-;Flavone,3′,4′,5,6,7,8-hexamethoxy-;Nobiletin;2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one;5,6,7,8,3′,4′-Hexamethoxyflavone;3′,4′,5,6,7,8-Hexamethoxyflavone;NSC 618903;NSC 76751;PMF 90;2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
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CAS No:
Description
Nobiletin is a citrus flavonoid with anti-inflammatory, anti-cancer, cholesterol lowering, memory protection activities.
Solid
Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. It has a role as a plant metabolite and an antineoplastic agent. It derives from a flavone.
Characteristics
81.7
3
Solid
1.2±0.1 g/cm3
136.5-137.5 °C
587.9°C at 760 mmHg
256.5±30.2 °C
1.558
13.39 mg/L @ 25 °C (est)
-20°C
8.39E-14mmHg at 25°C
191.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
3
R36/37/38:Irritating to eyes, respiratory system and skin .
24/25
DJ3052200
Stable, but unstable if heated rapidly. Combustible. Incompatible with strong oxidizing agents, powdered aluminium, potassium.
Drug Information
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)
hexamethoxyflavone
Nobiletin Use and Manufacturing
Chuanpisu has anti-hemagglutination, anti-thrombosis, anti-cancer, anti-fungal, anti-inflammatory, anti-inflammatory, anti-viral, anti-cancer, anti-mutation, anti-allergic, anti-ulcer, analgesic, blood pressure lowering activity, and lowering blood cholesterol. effect.
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:402.4
XLogP3:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:402.13146766
Monoisotopic Mass:402.13146766
Topological Polar Surface Area:81.7
Heavy Atom Count:29
Complexity:593
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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