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Propyphenazone

Propyphenazone structure

CAS No:
479-92-5
Formula:
C14H18N2O
Chemical Name:
Propyphenazone
Synonyms:
3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-;Antipyrine,4-isopropyl-;1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one;Isopropylantipyrine;4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;Isopropylphenazone;Larodon;1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one;1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one;Propyphenazone;4-Isopropylantipyrine;1,2-Dihydro-1,5-dimethyl-2-phenyl-4-isopropyl-3H-pyrazol-3-one;Isopropylantipyrin;Isopropyrine;Propyfenazone;Arantil P;Isopropchin;4-Isopropylphenazone;Budirol;Eufibron;Cibalgina;Causyth;1,5-Dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one;128065-64-5;12542-35-7;88205-06-5
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.Target：COX-2Propyphenazone is structurally related to aminophenazone it has been associated with severe blood dyscrasias. Propyphenazone is introduced for the treatment of rheumatic disorders.

Propyphenazone is a pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic and a peripheral nervous system drug. It derives from an antipyrine.

Propyphenazone Basic Attributes

Molecular Weight：

230.31

Exact Mass：

230.31

EC Number：

207-539-2

UNII：

OED8FV75PY

DSSTox ID：

DTXSID6023529

ATC Code：

N - Nervous system

HScode：

2933199090

Characteristics

PSA：

23.6

XLogP3：

1.74

Density：

1.1±0.1 g/cm3

Melting Point：

103 °C

Boiling Point：

319.0±25.0 °C at 760 mmHg

Flash Point：

123.8±15.5 °C

Refractive Index：

1.556

Water Solubility：

743.6g/L(25.35 ºC)

Storage Conditions：

Refrigerator

Collision Cross Section：

150 Å² [M+H]+ [CCS Type: TW]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-22

safety instructions：

26-36/37/39

RTECS Number：

CD2800000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one

Propyphenazone Use and Manufacturing

Uses

Analgesic; antipyretic; anti-inflammatory.

Manufacturing Info：

3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-: INACTIVE

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:230.31
XLogP3:1.7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:230.141913202
Monoisotopic Mass:230.141913202
Topological Polar Surface Area:23.6
Heavy Atom Count:17
Complexity:340
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Inhibits prostaglandin synthesis and has antipyretic and analgesic effects

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound acetaminophen tablets (Ⅱ)
Ingredients	Acetaminophen 250 mg, isopropyl antipyrine 150 mg, anhydrous caffeine 50 mg. Excipients: microcrystalline cellulose, hypromellose, formaldehyde casein, corn starch, magnesium stearate, talc, micro powder silica gel.
Indication	1. Patients who use barbiturates (such as phenbital) or antispasmodics (such as belladonna) may suffer liver damage if they use this product for a long time, so they should not be taken together. 2. This product can enhance the toxicity of chloramphenicol when used together, so they should not be taken together. 3. If used together with other drugs, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	Acetaminophen 0.25g, isopropyl antipyrine 0.15g, anhydrous caffeine 50mg
Manufacturer	Chongqing KERUI Pharmaceutical (GROUP) Co., Ltd.

Isopropylantipyrine
Manufacturer	Zhejiang Haisen Pharmaceutical Co., Ltd.

Compound acetaminophen tablets (Ⅱ)
Ingredients	This product is a compound preparation, each tablet contains 250 mg of acetaminophen, 150 mg of isopropyl antipyrine, and 50 mg of anhydrous caffeine. Excipients are: low-substituted hydroxypropyl cellulose, silicon dioxide, magnesium stearate, povidone, cross-linked carboxymethyl cellulose sodium, starch, and hydroxypropyl methylcellulose.
Indication	1. It should not be used with anticoagulants (such as dicoumarol, heparin). 2. This product can increase gastrointestinal adverse reactions when used with corticosteroids. 3. This product should not be taken with chloramphenicol, barbiturates, and belladonna drugs. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Compound
Manufacturer	Southwest Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Zhejiang Haisen Pharmaceutical Co., Ltd.

China
Active
Shandong Xinhua Pharmaceutical Company Limited

China
Active
SHANDONG XINHUA PHARMACEUTICAL CO., LTD.

European Union
Active

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