Roxarsone

263.04

263.04

204-453-7

H5GU9YQL7L

757312|2101

1557

DTXSID9020956

Tufts of pale-yellow needles or rhombohedral plates from water|Pale-yellow crystals

29319090

124

-0.51

4-hydroxy-3-nitrophenyl arsonic acid appears as pale yellow crystals or light tan powder. (NTP, 1992)

2.02 g/cm³

≥300 °C(lit.)

537.3±60.0 °C(Predicted)

240.3±21.3 °C

H2O: <0.1 g/100 mL at 23 ºC;Slightly sol in cold water; freely sol in methanol, ethanol, acetic acid, acetone, alkalies; sol in about 30 parts boiling water; insol in ether, ethyl acetate; sparingly sol in dil mineral acids.

0-6°C

2.24E-12mmHg at 25°C

Oral-rat LDL0: 82 mg/kg; Oral-Mouse LD50: 244 mg/kg

Thermal decomposition of toxic nitrogen oxides and arsenide gases

145.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Puffs up and deflagrates on heating

Insoluble in water.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

May be sensitive to light and elevated temperatures on long-term storage. It puffs up and deflagrates on heating. Incompatible with strong oxidizers and strong acids. Forms mono-, di-, and trisodium salts. (NTP, 1992)

III

6.1(b)

UN 3465 6.1/PG 2

3

23/25-50/53

20/21-28-45-60-61

CY5250000

T,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable under normal shipping and handling conditions.

P261-P273-P301 + P310-P311-P501

H301 + H331-H410

Roxarsone tablets. ... Conditions of use: growing chickens and growing turkeys ... Indications for use: For increased rate of weight gain, improved feed efficiency, and improved pigmentation. ... Conditions of use: swine ... Indication for use: As an aid in the treatment of swine dysentery (hemorrhagic enteritis or bloody scours).

DHHS/ATSDR; Toxicological Profile for Arsenic (Update) TP-92/02 (1993)|DHHS/NTP; Toxicology & Carcinogenesis Studies of Roxarsone in F344/N Rats and B6C3F1 Mice (Feed Studies) Technical Report Series No. 345 (1989) NIH Publication No. 89-2800

Flash point data are not available for this chemical; however, it is probably combustible. (NTP, 1992)

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 92 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material may be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 3-Nitro-4-hydroxyphenylarsonic acid is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

highly toxic

LD50 Rat oral 81 mg/kg|LD50 Mouse oral 244 mg/kg|LD50 Chicken oral 110 mg/kg|LD50 Chicken ip 34 mg/kg|For more Non-Human Toxicity Values (Complete) data for 3-NITRO-4-HYDROXYPHENYLARSONIC ACID (8 total), please visit the HSDB record page.

... Toxicology and carcinogenesis studies were conducted by admin roxarsone (greater than 99.4% pure) in feed to groups of F344/N rats and B6C3F1 mice of each sex for ... 2 years. ... Dietary concn of roxarsone selected for the 2 yr studies were 0, 50, or 100 ppm for rats and 0, 100, or 200 ppm for mice. Conclusions: Under the conditions of these 2 yr feed studies, there was equivocal evidence of carcinogenic activity of roxarsone for male F344/N rats, as indicated by a marginally incr incidence of adenomas of the exocrine pancreas. There was no evidence of carcinogenic activity for female F344/N rats fed diets containing 50 or 100 ppm roxarsone for 2 yr. There was no evidence of carcinogenic activity for male or female B6C3F1 mice fed diets containing 100 or 200 ppm roxarsone for 2 yr.

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

WHEN GIVEN ORALLY, CONSIDERABLE PERCENTAGE IS EXCRETED IN FECES, INDICATING THAT PHENYLARSONIC COMPD ARE POORLY ABSORBED BY INTESTINAL TRACT. THAT PROP WHICH IS ABSORBED, HOWEVER IS APPARENTLY EXCRETED RAPIDLY BY THE KIDNEYS.|4-WK-OLD CHICKENS FED DAILY RATION WITH 50 PPM ROXARSONE & SACRIFICIED. PPM ARSENIC IN CONTROLS: KIDNEY 0.05, LIVER 0.08, MUSCLE 0.02, SKIN 0.02; ARSENIC IN TREATED ANIMALS KILLED ON 70TH DAY: KIDNEY 0.64, LIVER 1.26, MUSCLE 0.04, SKIN 0.05.|IT IS ESTABLISHED THAT ARSANILIC ACID & ACETYLARSONIC ACID ARE EXCRETED UNCHANGED BY CHICKENS. SIMILAR RESULTS WERE OBTAINED IN STUDIES WITH 3-NITRO-4-HYDROXYBENZENEARSONIC ACID IN CHICKENS.|There are only a few reports on the excretion of arsenic in the milk of animals. The arsenic level in cow's milk did not incr with the blood concn when the cows were fed methylarsonic acid or dimethylarsinic acid... . However, the milk arsenic levels did incr when cows were fed arsanilic acid or 3-nitro-4-hydroxyphenylarsonic acid (1.6-3.2 mg As/kg bw)... .

SYMPTOMS: This compound may cause irritation. Symptoms of exposure to this class of compounds include restlessness, nausea, vomiting, headache, dizziness, chills, cramps, irritability and variable paralysis that may progress over a period of several weeks. Ventricular arrhythmias may occur. Inhalation of dusts may cause acute pulmonary edema, restlessness, dyspnea, cyanosis, cough with foamy sputum, and rales. The principle manifestations are gastrointestinal disturbances. Chronic poisoning can result in polyneuritis, optic neuritis, anesthesias, paresthesias, bronzing of the skin, alopecia, localized edema, dermatitis, liver cirrhosis, abdominal pain, salivation, anemia, weight loss, chronic nephritis, cardiac failure and dependent edema. Ingestion of lethal doses of this type of compound can cause violent gastroenteritis, convulsions and coma. Death may occur from circulatory failure. ACUTE/CHRONIC HAZARDS: This compound is highly toxic by ingestion. It may be fatal by inhalation or skin absorption. When heated to decomposition it emits very toxic fumes of carbon monoxide and carbon dioxide. It also emits toxic fumes of nitrogen oxides and arsenic oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

3 Nitro 10

Arsonic acid, As-(4-hydroxy-3-nitrophenyl)-: ACTIVE|FORMS MONO-, DI-, & TRISODIUM SALTS.|APPLICATIONS (VET): DO NOT ADMIN TO DUCKS, GEESE, LAYING HENS, OR DOGS. ... ITS SAFE USE DEMANDS ADEQUATE WATER INTAKE & NO OTHER SOURCES OF ARSENIC. INCOORDINATION, RICKETS-LIKE APPEARANCE, & PARALYSIS CAN OCCUR UNDER THESE CONDITIONS.|APPLICATIONS (VET): FOR MANY YEARS IT HAD BEEN OTC FAVORITE FOR WATER MEDICATION OF CECAL COCCIDIOSIS IN CHICKS. OF VALUE IN IMPROVING PIGMENTATION IN CHICKENS & TURKEYS.|IS RECOMMENDED @ 25-50 PPM FOR CHICKENS & TURKEYS & @ 25-75 PPM FOR SWINE FOR IMPROVING WT GAIN & FEED EFFICIENCY. IT IS ALSO RECOMMENDED @ LEVEL OF 200 PPM FOR 5 DAYS FOR CONTROL OF SWINE DYSENTERY.

SPECTROPHOTOMETRY IN FEEDS; ANALYTICAL CHEMISTRY IN FEEDS.