Tangeretin
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Tangeretin
structure -
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CAS No:
481-53-8
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Formula:
C20H20O7
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Chemical Name:
Tangeretin
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Synonyms:
4H-1-Benzopyran-4-one,5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-;Flavone,4′,5,6,7,8-pentamethoxy-;Tangeretin;5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Ponkanetin;5,6,7,8,4′-Pentamethoxyflavone;4′,5,6,7,8-Pentamethoxyflavone;Tangeritin;NSC 53909;NSC 618905
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CAS No:
Description
Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.IC50 value:Target: Notch-1In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagge
Solid
Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.
Characteristics
72.4
3
Solid
1.2±0.1 g/cm3
154 °C
157°C at 0.17 mmHg
248.4±30.2 °C
1.566
H2O: insoluble
8.41E-13mmHg at 25°C
187.9 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|208.15 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|182 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|186.7 Ų [M+H]+
Safety Information
Ⅲ
UN 2811
3
25-36/37/38
45-36-26
DJ3102725
T,Xi
P264-P301 + P310
H300
|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 195 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Tangeretin has known human metabolites that include 4'-Hydroxy-5,6,7,8-tetramethoxyflavone and 5,6-Dihydroxy-7,8,4'-trimethoxyflavone.
4',5,6,7,8-pentamethoxy-flavone
Tangeretin Use and Manufacturing
antineoplastic
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:372.4
XLogP3:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:372.12090297
Monoisotopic Mass:372.12090297
Topological Polar Surface Area:72.4
Heavy Atom Count:27
Complexity:540
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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