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(-)-N-Methylcytisine

(-)-N-Methylcytisine structure

CAS No:
486-86-2
Formula:
C12H16N2O
Chemical Name:
(-)-N-Methylcytisine
Synonyms:
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methyl-,(1R,5S)-;Cytisine,12-methyl-;1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methyl-,(1R)-;Cytisine,methyl-;Cytisine,N-methyl-;(1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one;N-Methylcytisine;Caulophylline;Caulophyllin;(-)-N-Methylcytisine;3-Methylcytisine;28463-18-5
Categories:
Biochemical Engineering > Chinese Herbs

Description

N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].

(-)-N-Methylcytisine Basic Attributes

Molecular Weight：

204.27

Exact Mass：

204.27

EC Number：

207-643-8

Characteristics

PSA：

25.24000

XLogP3：

0.46

Density：

1.2±0.1 g/cm3

Melting Point：

137 °C

Boiling Point：

140-170 °C @ Press: 0.01 Torr

Flash Point：

191.9±18.0 °C

Refractive Index：

1.616

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Vapor Pressure：

1.24E-06mmHg at 25°C

Toxicity：

LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)

Specific rotation：

30D -224° (c = 1.05 in water)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

RTECS Number：

HA4400000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

N-methyl-cytisine

Computed Properties

Molecular Weight:204.27
XLogP3:0.7
Hydrogen Bond Acceptor Count:2
Exact Mass:204.126263138
Monoisotopic Mass:204.126263138
Topological Polar Surface Area:23.6
Heavy Atom Count:15
Complexity:359
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (-)-N-Methylcytisine

Henan Lihao Chem Plant Limited Contact Supplier

CN
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Caulophylline 99% white powder kanbei

CAS No.: 486-86-2

Grade: Industrial Grade

Content: 99%

Inquiry

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Guide of (-)-N-Methylcytisine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Recommended Suppliers
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(-)-N-Methylcytisine

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