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Resibufogenin

Resibufogenin structure

CAS No:
465-39-4
Formula:
C24H32O4
Chemical Name:
Resibufogenin
Synonyms:
Bufa-20,22-dienolide,14,15-epoxy-3-hydroxy-,(3β,5β,15β)-;5β-Bufa-20,22-dienolide,14,15β-epoxy-3β-hydroxy-;(3β,5β,15β)-14,15-Epoxy-3-hydroxybufa-20,22-dienolide;Bufogenin;14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide;3β-Hydroxy-14,15β-epoxy-5β-bufa-20,22-dienolide;Resibufogenin;Respigon;Resi;Recibufogenin;NSC 90783;Resinobufagin
Categories:
Biochemical Engineering > Saccharides

Description

Resibufogenin, a component of huachansu, has been shown to exhibit the anti-proliferative effect against cancer cells, and this may be attributed to the degradation of cyclin D1 caused by the activation of GSK-3β.IC50 Value:Target:In vitro: The effects of Resibufogenin on the outward delayed rectifier potassium current (IK) and outward transient potassium current (IA) in rat hippocampal neurons was investigated, and it inhibited both IK and IA, at 1 μM concentration RBG could alter some

Resibufogenin Basic Attributes

Molecular Weight：

384.51

Exact Mass：

384.51

NSC Number：

90783|248525|237769

HScode：

29322090

Characteristics

PSA：

59.1

XLogP3：

3.7

Appearance：

White to off-white solid.

Density：

1.3±0.1 g/cm3

Melting Point：

155 °C

Boiling Point：

554.9°C at 760 mmHg

Flash Point：

190.7±23.6 °C

Refractive Index：

1.603

Storage Conditions：

Store in original container in a cool dark place.

Vapor Pressure：

1.26E-14mmHg at 25°C

Toxicity：

Oral-mouse LD50: 6.4 mg/kg; peritoneal-mouse LD50: 16.3 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic and spicy and irritating smoke

Specific rotation：

D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

3172

safety instructions：

24/25

Storage features：

The warehouse is ventilated, low temperature and dry; stored separately from food raw materials

Precautionary statement(s)：

P260-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233

Hazard Statements：

H300 + H310 + H330

Toxicity

Toxicity class：

most toxic

Computed Properties

Molecular Weight:384.5
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:384.23005950
Monoisotopic Mass:384.23005950
Topological Polar Surface Area:59.1
Heavy Atom Count:28
Complexity:786
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Resibufogenin

CAS No.: 465-39-4

Content: 99.00%

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Guide of Resibufogenin

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Computed Properties
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