Proscillaridin
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Proscillaridin
structure -
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CAS No:
466-06-8
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Formula:
C30H42O8
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Chemical Name:
Proscillaridin
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Synonyms:
Bufa-4,20,22-trienolide,3-[(6-deoxy-α-L-mannopyranosyl)oxy]-14-hydroxy-,(3β)-;Proscillaridin A;(3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide;Proscillaridin;Talusin;Transvaalin,degluco-;3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide;14-Hydroxy-3β-(rhamnosyloxy)bufa-4,20,22-trienolide;3β-Rhamnosido-14β-hydroxy-Δ4,20,22-bufatrienolide;Desglucotransvaaline;Scillarenin 3β-rhamnoside;Caradrin;Cardion;Carmazon;Herzo Proscillan;Prostosin;Protasin;Purosin-TC;Sandoscill;Scillacrist;Solestril;Simeon;Stellarid;Urgilan;Cardiovite;PSC-801;Coratol;Procilan;Procardin;Tradenal;Proscillan;Wirnesin;Proszine;Talucard;A 32686;Desglucotrnasvaaline;NSC 7521;Proslladin;12041-88-2;14008-49-2
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CAS No:
Description
Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1].
A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).
Characteristics
126
3.90
1.3±0.1 g/cm3
221 °C
716.7±60.0 °C at 760 mmHg
232.6±26.4 °C
1.620
2-8°C
LD50 in male, female rats (mg/kg): 56, 76 orally (Goldenthal)
D20 -91.5° (CH3OH)
Safety Information
UN 2811 6.1/PG 3
3
25
28-45
UK6650000
T
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.
Drug Information
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Caradrin
Computed Properties
Molecular Weight:530.6
XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:530.28796829
Monoisotopic Mass:530.28796829
Topological Polar Surface Area:126
Heavy Atom Count:38
Complexity:1070
Defined Atom Stereocenter Count:7
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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