tert-Butyl peroxide

146.22700

146.23

203-733-6

M7ZJ88F4R1

1019

673

3107|2102

DTXSID2024955

Clear, water-white liquid|Liquid at 20 °C|Yellow liquid

2909600000

18.46000

2.53160

Di-tert-butyl peroxide is a clear colorless liquid. (NTP, 1992)

0.7910 g/cm³ @ Temp: 25 °C

-40 °C

111 °C

34

1.388-1.390

H2O: immiscible

2-8ºC

40 mm Hg ( 20 °C)

Relative vapour density (air = 1): 5

Seven organic peroxides were tested for propagation and power of explosion, and for shock sensitivity. Tert-butylperoxybenzoate and dibenzoylperoxide showed high shock sensitivity and explosive powers of 40 and 25% of TNT respectively. Di-tert-butylperoxide showed medium sensitivity and a power of 30% TNT. Cumyl hydroperoxide (80% in cumene), dibenzoylperoxide (75% in water), dicumyl peroxide and dilauroyl peroxide did not propagate explosion.

Henry's Law constant = 0.0483 atm-cu m/mol at 25 °C (est)

Evaporates with decomposition and without violence at 91 °C|Decomposes at 190 °C|Strong oxidizer; may explode when shocked|Maximum storage temperature: 38 °C; Self-Accelerating Decomposition Temperature (SADT): 80 °C ... Vapors are highly flammable|For more Other Experimental Properties (Complete) data for Bis(1,1-dimethylethyl)peroxide (6 total), please visit the HSDB record page.

No rapid reaction with air. No rapid reaction with water.

Peroxides, Organic

Explosive

The explosive instability of the lower dialkyl peroxides (e.g., dimethyl peroxide) and 1,1-bis-peroxides decreases rapidly with increasing chain length and degree of branching, the di-tert-alkyl derivatives being amongst the most stable class of peroxides. Though many 1,1-bis-peroxides have been reported, few have been purified because of the higher explosion hazards compared with the monofunctional peroxides. It is unlikely that this derivative would be particularly unstable compared to other peroxides in its class [Bretherick 2nd ed., p 44 1979].

The vapour is heavier than air and may travel along the ground; distant ignition possible.

II

5.2

UN 3107

1

R11; R7

S14-S16-S3/7-S36/37/39

ER2450000

F

Fireproof. Separated from combustible substances and reducing agents. Cool. Well closed.

May decompose explosively if heated, subjected to shock, or treated with reducing agents. Highly flammable. Refrigerate.

P210-P220-P273-P280-P410-P411 + P235

H225-H242-H341-H412

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Incompatible materials: Strong reducing agents, powdered metals, strong bases.|Strong oxidizer, may ignite organic materials or explode when shocked or in contact with reducing materials.

Preliminary 2D Animation of Events Leading to 2017 Fire at Arkema Chemical Plant in Crosby, Texas.[U.S. Chemical Safety Board; Preliminary 2D Animation of Events Leading to 2017 Fire at Arkema Chemical Plant in Crosby, Texas; Available from, as of November 27, 2017: http://www.csb.gov/videos/preliminary-2d-animation-of-events-leading-to-2017-fire-at-arkema-chemical-plant-in-crosby-texas/]|USEPA/ITC; Information Review: Tertiary Alkyl Peroxides (Addendum-A) (1984)|Lai DY, et al; J Environ Sci Hlth 14 (1, Pt C): 63-80 (1996). Carcinogenic potential of organic peroxides prediction based on structure activity relationships and mechanism based short term test.

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]: May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated. Runoff may create fire or explosion hazard. (ERG, 2016)|Highly flammable. Many reactions may cause fire or explosion. Vapour/air mixtures are explosive.|Flammable - 3rd degree, Reactive - 4th degree

|Danger|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P220, P233, P234, P240, P241, P242, P243, P280, P281, P303+P361+P353, P308+P313, P370+P378, P403+P235, P405, P411, P420, and P501|H225 (99.92%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P220, P233, P234, P240, P241, P242, P243, P261, P264, P280, P281, P285, P303+P361+P353, P304+P341, P305+P351+P338, P308+P313, P337+P313, P342+P311, P370+P378, P403+P235, P405, P411, P420, and P501|Aggregated GHS information provided by 1268 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P210, P220, P233, P234, P240, P241, P242, P243, P273, P280, P281, P303+P361+P353, P308+P313, P370+P378, P403+P235, P405, P411, P420, and P501|P210, P220, P233, P234, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, P411, P420, and P501

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. LARGE SPILL: Consider initial evacuation for at least 250 meters (800 feet) in all directions. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Keep substance wet using water spray. Stop leak if you can do it without risk. SMALL SPILL: Pick up with inert, damp, non-combustible material using clean, non-sparking tools and place into loosely covered plastic containers for later disposal. LARGE SPILL: Wet down with water and dike for later disposal. Prevent entry into waterways, sewers, basements or confined areas. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2016)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Eye/face protection: Face shield and safety glasses. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|Protective gloves. Wear safety spectacles.

Flammable liquid.|Prevention: No open flames, no sparks and no smoking. No contact with flammables. No contact with contaminants. No contact with hot surfaces.|Flammable, dangerous fire hazard.

Vapor/air mixtures are explosive.|Prevention: Closed system, ventilation, explosion-proof electrical equipment and lighting. Do not use compressed air for filling, discharging, or handling.|Seven organic peroxides were tested for propagation and power of explosion, and for shock sensitivity. Tert-butylperoxybenzoate and dibenzoylperoxide showed high shock sensitivity and explosive powers of 40 and 25% of TNT respectively. Di-tert-butylperoxide showed medium sensitivity and a power of 30% TNT. Cumyl hydroperoxide (80% in cumene), dibenzoylperoxide (75% in water), dicumyl peroxide and dilauroyl peroxide did not propagate explosion.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.|Use water spray to cool unopened containers.|Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.|Warning: Water may not work to fight fire.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.|Personal protection: filter respirator for organic gases and vapors adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do not wash away into sewer. Do not absorb in saw-dust or other combustible absorbents.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge. Keep away from heat and sources of ignition.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|For more Preventive Measures (Complete) data for Bis(1,1-dimethylethyl)peroxide (9 total), please visit the HSDB record page.

/GUIDE 145 ORGANIC PEROXIDES (Heat and Contamination Sensitive)/ Fire or Explosion: May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated. Runoff may create fire or explosion hazard. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/|/GUIDE 145 ORGANIC PEROXIDES (Heat and Contamination Sensitive)/ Health: Fire may produce irritating, corrosive and/or toxic gases. Ingestion or contact (skin, eyes) with substance may cause severe injury or burns. Runoff from fire control or dilution water may cause pollution. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/|/GUIDE 145 ORGANIC PEROXIDES (Heat and Contamination Sensitive)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind, uphill and/or upstream. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/|/GUIDE 145 ORGANIC PEROXIDES (Heat and Contamination Sensitive)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/|For more DOT Emergency Guidelines (Complete) data for Bis(1,1-dimethylethyl)peroxide (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Organic peroxide type E, liquid and Organic peroxide type F, liquid are included on the dangerous goods list. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Organic peroxide type E, liquid and Organic peroxide type F, liquid are included on the dangerous goods list. /Organic peroxide type E, liquid; Organic peroxide type F, liquid/

A powerful irritant by ingestion and inhalation. A mild skin and eye irritant.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Do NOT absorb in saw-dust or other combustible absorbents.

Fireproof. Separated from combustible substances and reducing agents. Cool. Well closed.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes and respiratory tract.

NO open flames, NO sparks and NO smoking. NO contact with flammables. NO contact with contaminants. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

PREVENT GENERATION OF MISTS!

Use ventilation.

Protective gloves.

Wear safety spectacles.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 4 - Materials that in themselves are readily capable of detonation or explosive decomposition or explosive reaction at normal temperatures and pressures.|OX - Oxidizer: Materials that possess oxidizing properties.

IDENTIFICATION AND USE: Bis(1,1-dimethylethyl) peroxide is a liquid. It is used as a polymerization catalyst for resins, including olefins, styrene, styrenated alkyds, and silicones. It is also used as an ignition accelerator for diesel fuel, and an organic synthesis intermediate. HUMAN STUDIES: Workers engaged in the production of organic peroxides suffered from grippe, angina, acute respiratory diseases, and pneumonia. ANIMAL STUDIES: Tumorigenic response after exposure of di-tert-butyl peroxide at a single dose of 100 umol to 50 mice consisted of 7 animals with malignant lymphomas and 1 animal with pulmonary adenomas out of 35 survivors. Di-t-butyl peroxide, which was essentially inactive in short-term in vitro promotion assays, was also totally inactive in promoting papillomas or carcinomas in initiated skin. Chromosome breakage has been detected using tert-butyl peroxide. The mutagenicity of di-t-butyl peroxide was tested using Salmonella typhimurium TA 98 and TA 100 in the presence of metabolic activation. No mutagenic activity was observed with di-t-butyl peroxide.

Effect of peroxide administration on chick growth, severity of exudative diathesis, and glutathione peroxidase ... was greatly influenced by dietary selenium level but little if any relationship of this disease to peroxide induced reductions in glutathione peroxidase activity. ... Tertiary butyl peroxide administration caused depression in glutathione peroxidase activity in liver.

LD50 Rat ip 3210 mg/kg|LD50 Mouse oral 20 g/kg

Bis(1,1-dimethylethyl)peroxide is of anthropogenic origin, and is not known to be produced by natural sources. (SRC)

Bis(1,1-dimethylethyl)peroxide's production and use as a polymerization catalyst(1) for resins, including olefins, styrene, styrenated alkyds, and silicones and an ignition accelerator for diesel fuel, in organic synthesis, as an intermediate(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 620(SRC), determined from a structure estimation method(2), indicates that bis(1,1-dimethylethyl)peroxide is expected to have moderate mobility in soil(SRC). Volatilization of bis(1,1-dimethylethyl)peroxide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.0483 atm-cu m/mole(SRC), based upon its vapor pressure, 25.1 mm Hg(3), and water solubility, 100 mg/L(4). Bis(1,1-dimethylethyl)peroxide is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(4) indicating that biodegradation is not an important environmental fate process in soil(SRC). Organic peroxides, such as bis(1,1-dimethylethyl)peroxide, are strong oxidizers and may ignite organic materials in soil on contact(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 620(SRC), determined from a structure estimation method(2), indicates that bis(1,1-dimethylethyl)peroxide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.0483 atm-cu m/mole(SRC), derived from its vapor pressure, 25.1 mm Hg(4), and water solubility, 100 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hrs and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 88(SRC), from an estimated log Kow of 32.45(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(7) indicating that biodegradation is not an important environmental fate process in water(SRC). Organic peroxides, such as bis(1,1-dimethylethyl)peroxide, are strong oxidizers and may ignite organic materials in water on contact(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(1,1-dimethylethyl)peroxide, which has a vapor pressure of 25.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase bis(1,1-dimethylethyl)peroxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 days(SRC), calculated from its rate constant of 1.0X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Bis(1,1-dimethylethyl)peroxide absorbs UV light at wavelengths of 340 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of bis(1,1-dimethylethyl)peroxide with photochemically-produced hydroxyl radicals has been estimated as 1.0X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 15 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Bis(1,1-dimethylethyl)peroxide has a reported hydrolysis half-life of 1 years at 25 °C(2). Bis(1,1-dimethylethyl)peroxide absorbs UV light at wavelengths of 340 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). The compound photolyzes to form two t-butoxy radicals(3,4). The t-butoxy radical is unstable and decomposes to form acetone and methyl radicals. A host of other products result from free radical reactions including t-butanol, methyl t-butyl ether, isobutylene oxide, ethane, and methane(3,4). Organic peroxides, such as bis(1,1-dimethylethyl)peroxide, are strong oxidizers and may ignite organic materials in soil and water on contact(5).|The main causes of unintended decompositions of organic peroxides are heat energy from heating sources and mechanical shock, ie, impact or friction. In addition, certain contaminants, ie, metal salts, amines, acids, and bases, initiate or accelerate organic peroxide decompositions at temperatures at which the peroxide is normally stable. These reactions also liberate heat, thus further accelerating the decomposition. Commercial products often contain diluents that desensitize neat peroxides to these hazards. Commercial organic peroxide decompositions are low order deflagrations rather than detonations. /Organic peroxides/

An estimated BCF of 88 was calculated in fish for bis(1,1-dimethylethyl)peroxide(SRC), using an estimated log Kow of 3.45(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of bis(1,1-dimethylethyl)peroxide can be estimated to be 620(SRC). According to a classification scheme(2), this estimated Koc value suggests that bis(1,1-dimethylethyl)peroxide is expected to have moderate mobility in soil.

The Henry's Law constant for bis(1,1-dimethylethyl)peroxide is estimated as 0.0483 atm-cu m/mole(SRC) derived from its vapor pressure, 25.1 mm Hg(1), and water solubility, 100 mg/L(2). This Henry's Law constant indicates that bis(1,1-dimethylethyl)peroxide is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). The potential for volatilization of bis(1,1-dimethylethyl)peroxide from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

According to the 2016 TSCA Inventory Update Reporting data, 4 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of bis(1,1-dimethylethyl)peroxide in the United States may be as low as 25 workers and as high as 50 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 20,561 workers (6371 of these are female) were potentially exposed to bis(1,1-dimethylethyl)peroxide in the US(1). Occupational exposure to bis(1,1-dimethylethyl)peroxide may occur through inhalation and dermal contact with this compound at workplaces where bis(1,1-dimethylethyl)peroxide is produced or used. The general population is not likely to be exposed to bis(1,1-dimethylethyl)peroxide except in the immediate vicinity of an accident site(SRC).

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]: Fire may produce irritating, corrosive and/or toxic gases. Ingestion or contact (skin, eyes) with substance may cause severe injury or burns. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Fresh air, rest. Half-upright position. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic peroxides/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic peroxides/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5K TKO. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic peroxides/

/SIGNS AND SYMPTOMS/ Workers engaged in the production of organic peroxides, eg, tert-butyl perbenzoate and di-tert-butyl peroxide, suffered from grippe, angina, acute respiratory diseases, pneumonia ... .

di-t butyl peroxide

The substance can be absorbed into the body by inhalation of its vapour.

Cough. Shortness of breath. Sore throat.

Redness. Pain.

CADOX|CADOX TBP|TRIGONOX B

All other basic organic chemical manufacturing|Peroxide, bis(1,1-dimethylethyl): ACTIVE

In this work we found that there were five decomposition products of di-t-butyl peroxide at 320 degrees C by GC-MS. The peak area of acetone as a chief product in the thermal decomposition was related to di-t-butyl peroxide concentration in a linear manner. The range was from 22.91 to 114.93 ug (r=0.9997, n=4). By use of the calibration, we can possibly determine the content of the peroxide rapidly. The present method is more suitable for the determination of peroxide that is liable to decompose and difficult to be vaporized.

Fire Hazards -> Flammable - 3rd degree, Reactive - 4th degree