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2-Amino-5-nitropyridine

2-Amino-5-nitropyridine structure

CAS No:
4214-76-0
Formula:
C5H5N3O2
Chemical Name:
2-Amino-5-nitropyridine
Synonyms:
2-Pyridinamine,5-nitro-;Pyridine,2-amino-5-nitro-;5-Nitro-2-pyridinamine;2-Amino-5-nitropyridine;5-Nitro-2-aminopyridine;5-Nitropyridin-2-ylamine;NSC 23774
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

YELLOW FINE CRYSTALLINE POWDER

2-Amino-5-nitropyridine Basic Attributes

Molecular Weight：

139.11

Exact Mass：

139.11

BRN：

120353

EC Number：

224-145-6

NSC Number：

23774

DSSTox ID：

DTXSID6063357

HScode：

29333999

Characteristics

PSA：

84.7

XLogP3：

0.9

Appearance：

Yellow Crystalline Powder

Density：

1.4±0.1 g/cm3

Melting Point：

186-188 °C

Boiling Point：

293.8°C at 760 mmHg

Flash Point：

224°(435°F)

Refractive Index：

1.646

Storage Conditions：

Store below +30°C.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39-24/25-36

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-amino-5-nitropyridine

2-Amino-5-nitropyridine Use and Manufacturing

Methods of Manufacturing

Derived from 2-aminopyridine nitration. At a temperature of 50°C, add 2-aminopyridine to concentrated sulfuric acid, and then add fuming nitric acid dropwise. The temperature does not exceed 50°C. Incubate at 45°C for 2 hours and stir at room temperature for 4 hours. The reaction liquid was poured into crushed ice, and ammonia water was added to adjust the pH to 6 below 5°C, and crystals were precipitated. Filter and dry. Recrystallize with water to obtain light yellow platelets, the yield is 75%

Uses

Used as pharmaceutical intermediates.

Manufacturing Info：

2-Pyridinamine, 5-nitro-: INACTIVE

Computed Properties

Molecular Weight:139.11
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:139.038176411
Monoisotopic Mass:139.038176411
Topological Polar Surface Area:84.7
Heavy Atom Count:10
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Nitric acid

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