Cladribine
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Cladribine
structure -
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CAS No:
4291-63-8
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Formula:
C10H12ClN5O3
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Chemical Name:
Cladribine
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Synonyms:
Adenosine,2-chloro-2′-deoxy-;2-Chloro-2′-deoxyadenosine;2-Chloro-2′-deoxy-β-adenosine;2-Chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine;2-Chlorodeoxyadenosine;NSC 105014-F;Cladribine;RWJ 26251;Leustatin;2-CdA;Cladarabine;NSC 105014;CldAdo;Jk 6251;Biodribin;Leustat;(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;Vero-Cladribine;Mavenclad;Litak;24757-90-2
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CAS No:
Characteristics
119
-0.1
Solid
2.03±0.1 g/cm3(Predicted)
208-210 °C @ Solvent: Ethanol
387.1°C at 760 mmHg
6.35e+00 g/L
2-8°C
1.11X10-13 mm Hg at 25 deg C (est)
LD50 intraperitoneal in mouse: 150mg/kg
D25 -18.8° (c = 1 in DMF)
Safety Information
3
36/37/38-23/24/25
26-37/39-45-36-22
AU7357560
T
Store in Freezer
P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501
H301
Computed Properties
Molecular Weight:285.69
XLogP3:0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:285.0628670
Monoisotopic Mass:285.0628670
Topological Polar Surface Area:119
Heavy Atom Count:19
Complexity:338
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
The anti-tumor activity of cladribine is related to the activity of deoxycytidine kinase and deoxynucleotide kinase. It enters cells mainly through passive transport, is phosphorylated by deoxycytidine kinase in cells, converted into cladribine triphosphate, and incorporated into DNA molecules, hindering the repair of DNA after breakage, causing the depletion of NAD and ATP, destroying cell metabolism, and affecting cell DNA synthesis. Therefore, this product has the effect of inhibiting DNA synthesis and repair on differentiated or quiescent lymphocytes and monocytes.
Registered Holders
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BIOPHORE INDIA PHARMACEUTICALS PVT LTD
Active
United States
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RELIABLE BIOPHARMACEUTICAL LLC
Active
United States
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Taige Kanglihua (Beijing) Consulting Services Co., Ltd.
Active
China
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